In Vitro Antifungal Activity of Ibrexafungerp (SCY-078) Against Contemporary Blood Isolates From Medically Relevant Species of Candida

Ibrexafungerp (SCY-078) is the newest oral and intravenous antifungal drug with broad activity, currently undergoing clinical trials for invasive candidiasis. The aim of this study was to assess the in vitro activity of ibrexafungerp and comparators against a collection of 434 European blood isolate...

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Detalhes bibliográficos
Autores: Quindós, Guillermo, Miranda-Cadena, Katherine, San-Millán, Rosario, Borroto-Esoda, Katyna, Cantón, Emilia, Linares-Sicilia, María José, Hamprecht, Axel, Montesinos, Isabel, Tortorano, Anna Maria, Prigitano, Anna, Vidal-García, Matxalen, Marcos-Arias, Cristina, Guridi, Andrea, Sanchez-Reus, Ferran|||0000-0002-6800-5487, Machuca-Bárcena, Jesús, Rodríguez-Iglesias, Manuel Antonio|||0000-0002-7097-9651, Martín-Mazuelos, Estrella, Castro-Méndez, Carmen, López-Soria, Leyre, Ruiz-Gaitán, Alba, Fernandez-Rivero, Marcelo, Lorenzo, Damaris, Capilla, Javier, Rezusta, Antonio, Pemán, Javier, Guarro Artigas, Josep, Pereira Coutinho, Joana, Pais, Célia, Romeo, Orazio, Ezpeleta, Guillermo, Jauregizar, Nerea, Angulo, David, Eraso, Elena
Tipo de documento: artigo
Data de publicação:2022
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:ddd.uab.cat:286309
Acesso em linha:https://ddd.uab.cat/record/286309
https://dx.doi.org/urn:doi:10.3389/fcimb.2022.906563
Access Level:Acceso aberto
Palavra-chave:Antifungal resistance
Antifungal testing
Candida
Caspofungin
EUCAST
Ibrexafungerp
Micafungin
SCY-078
Descrição
Resumo:Ibrexafungerp (SCY-078) is the newest oral and intravenous antifungal drug with broad activity, currently undergoing clinical trials for invasive candidiasis. The aim of this study was to assess the in vitro activity of ibrexafungerp and comparators against a collection of 434 European blood isolates of Candida. Ibrexafungerp, caspofungin, fluconazole, and micafungin minimum inhibitory concentrations (MICs) were collected from 12 European laboratories for 434 blood isolates, including 163 Candida albicans, 108 Candida parapsilosis, 60 Candida glabrata, 40 Candida tropicalis, 29 Candida krusei, 20 Candida orthopsilosis, 6 Candida guilliermondii, 2 Candida famata, 2 Candida lusitaniae, and 1 isolate each of Candida bracarensis, Candida catenulata, Candida dubliniensis, and Candida kefyr. MICs were determined by the EUCAST broth microdilution method, and isolates were classified according to recommended clinical breakpoints and epidemiological cutoffs. Additionally, 22 Candida auris from different clinical specimens were evaluated. Ibrexafungerp MICs ranged from 0.016 to ≥8 mg/L. The lowest ibrexafungerp MICs were observed for C. albicans (geometric MIC 0.062 mg/L, MIC range 0.016-0.5 mg/L) and the highest ibrexafungerp MICs were observed for C. tropicalis (geometric MIC 0.517 mg/L, MIC range 0.06-≥8 mg/L). Modal MICs/MICs (mg/L) against Candida spp. were 0.125/0.06 for C. albicans, 0.5/0.5 for C. parapsilosis, 0.25/0.25 for C. glabrata, 0.5/0.5 for C. tropicalis, 1/1 for C. krusei, 4/2 for C. orthopsilosis, and 0.5/0.5 for C. auris. Ibrexafungerp showed activity against fluconazole- and echinocandin-resistant isolates. If adopting wild-type upper limits, a non-wild-type phenotype for ibrexafungerp was only observed for 16/434 (3.7%) isolates: 11 (4.6%) C. parapsilosis, 4 (5%) C. glabrata, and 1 (2.5%) C. tropicalis. Ibrexafungerp showed a potent in vitro activity against Candida.

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