Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer
Reparació per recombinació homòloga; Càncer de pròstata metastàtic; Inhibidors de la poli(ADP-ribosa) polimerasa
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/7157 |
| Acceso en línea: | https://hdl.handle.net/11351/7157 |
| Access Level: | acceso abierto |
| Palabra clave: | Pròstata - Càncer - Tractament Metàstasi ADN - Reparació DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms::Prostatic Neoplasms, Castration-Resistant Other subheadings::Other subheadings::Other subheadings::/drug therapy PHENOMENA AND PROCESSES::Chemical Phenomena::Biochemical Phenomena::DNA Repair::Recombinational DNA Repair Other subheadings::Other subheadings::Other subheadings::/genetics ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata::neoplasias prostáticas resistentes a la castración Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia FENÓMENOS Y PROCESOS::fenómenos químicos::fenómenos bioquímicos::reparación del ADN::reparación del ADN por recombinación Otros calificadores::Otros calificadores::Otros calificadores::/genética |
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Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer |
| title |
Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer |
| spellingShingle |
Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer Gonzalez, David Pròstata - Càncer - Tractament Metàstasi ADN - Reparació DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms::Prostatic Neoplasms, Castration-Resistant Other subheadings::Other subheadings::Other subheadings::/drug therapy PHENOMENA AND PROCESSES::Chemical Phenomena::Biochemical Phenomena::DNA Repair::Recombinational DNA Repair Other subheadings::Other subheadings::Other subheadings::/genetics ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata::neoplasias prostáticas resistentes a la castración Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia FENÓMENOS Y PROCESOS::fenómenos químicos::fenómenos bioquímicos::reparación del ADN::reparación del ADN por recombinación Otros calificadores::Otros calificadores::Otros calificadores::/genética |
| title_short |
Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer |
| title_full |
Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer |
| title_fullStr |
Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer |
| title_full_unstemmed |
Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer |
| title_sort |
Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer |
| dc.creator.none.fl_str_mv |
Gonzalez, David Mateo Valderrama, Joaquim Stenzinger, Albrecht Rojo, Federico Shiller, Michelle Wyatt, Alexander W |
| author |
Gonzalez, David |
| author_facet |
Gonzalez, David Mateo Valderrama, Joaquim Stenzinger, Albrecht Rojo, Federico Shiller, Michelle Wyatt, Alexander W |
| author_role |
author |
| author2 |
Mateo Valderrama, Joaquim Stenzinger, Albrecht Rojo, Federico Shiller, Michelle Wyatt, Alexander W |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Gonzalez D] Patrick G Johnston Centre for Cancer Research, Queen’s University, Belfast, UK. [Mateo J] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Stenzinger A] Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. [Rojo F] Department of Pathology, IIS-Hospital Universitario Fundación Jiménez Díaz-CIBERONC, Madrid, Spain. [Shiller M] Department of Pathology, Baylor University Medical Center, Dallas, TX, USA. [Wyatt AW] Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Pròstata - Càncer - Tractament Metàstasi ADN - Reparació DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms::Prostatic Neoplasms, Castration-Resistant Other subheadings::Other subheadings::Other subheadings::/drug therapy PHENOMENA AND PROCESSES::Chemical Phenomena::Biochemical Phenomena::DNA Repair::Recombinational DNA Repair Other subheadings::Other subheadings::Other subheadings::/genetics ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata::neoplasias prostáticas resistentes a la castración Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia FENÓMENOS Y PROCESOS::fenómenos químicos::fenómenos bioquímicos::reparación del ADN::reparación del ADN por recombinación Otros calificadores::Otros calificadores::Otros calificadores::/genética |
| topic |
Pròstata - Càncer - Tractament Metàstasi ADN - Reparació DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms::Prostatic Neoplasms, Castration-Resistant Other subheadings::Other subheadings::Other subheadings::/drug therapy PHENOMENA AND PROCESSES::Chemical Phenomena::Biochemical Phenomena::DNA Repair::Recombinational DNA Repair Other subheadings::Other subheadings::Other subheadings::/genetics ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata::neoplasias prostáticas resistentes a la castración Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia FENÓMENOS Y PROCESOS::fenómenos químicos::fenómenos bioquímicos::reparación del ADN::reparación del ADN por recombinación Otros calificadores::Otros calificadores::Otros calificadores::/genética |
| description |
Reparació per recombinació homòloga; Càncer de pròstata metastàtic; Inhibidors de la poli(ADP-ribosa) polimerasa |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/7157 |
| url |
https://hdl.handle.net/11351/7157 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
The Journal of Pathology: Clinical Research;7(4) https://doi.org/10.1002/cjp2.203 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley |
| publisher.none.fl_str_mv |
Wiley |
| dc.source.none.fl_str_mv |
Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
| instname_str |
Departament de Salut de la Generalitat de Catalunya (DS) |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| collection |
Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
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| _version_ |
1869407143300431872 |
| spelling |
Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancerGonzalez, DavidMateo Valderrama, JoaquimStenzinger, AlbrechtRojo, FedericoShiller, MichelleWyatt, Alexander WPròstata - Càncer - TractamentMetàstasiADN - ReparacióDISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms::Prostatic Neoplasms, Castration-ResistantOther subheadings::Other subheadings::Other subheadings::/drug therapyPHENOMENA AND PROCESSES::Chemical Phenomena::Biochemical Phenomena::DNA Repair::Recombinational DNA RepairOther subheadings::Other subheadings::Other subheadings::/geneticsENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata::neoplasias prostáticas resistentes a la castraciónOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaFENÓMENOS Y PROCESOS::fenómenos químicos::fenómenos bioquímicos::reparación del ADN::reparación del ADN por recombinaciónOtros calificadores::Otros calificadores::Otros calificadores::/genéticaReparació per recombinació homòloga; Càncer de pròstata metastàtic; Inhibidors de la poli(ADP-ribosa) polimerasaReparación por recombinación homóloga; Cáncer de próstata metastásico; Inhibidores de la poli(ADP-ribosa) polimerasaHomologous recombination repair; Metastatic prostate cancer; Poly(ADP-ribose) polymerase inhibitorsAnalysis of the genomic landscape of prostate cancer has identified different molecular subgroups with relevance for novel or existing targeted therapies. The recent approvals of the poly(ADP-ribose) polymerase (PARP) inhibitors olaparib and rucaparib in the metastatic castration-resistant prostate cancer (mCRPC) setting signal the need to embed molecular diagnostics in the clinical pathway of patients with mCRPC to identify those who can benefit from targeted therapies. Best practice guidelines in overall biospecimen collection and processing for molecular analysis are widely available for several tumour types. However, there is no standard protocol for molecular diagnostic testing in prostate cancer. Here, we provide a series of recommendations on specimen handling, sample pre-analytics, laboratory workflow, and testing pathways to maximise the success rates for clinical genomic analysis in prostate cancer. Early involvement of a multidisciplinary team of pathologists, urologists, oncologists, radiologists, nurses, molecular scientists, and laboratory staff is key to enable optimal workflow for specimen selection and preservation at the time of diagnosis so that samples are available for molecular analysis when required. Given the improved outcome of patients with mCRPC and homologous recombination repair gene alterations who have been treated with PARP inhibitors, there is an urgent need to incorporate high-quality genomic testing in the routine clinical pathway of these patients.JM has served on advisory boards for Amgen, AstraZeneca, Clovis Oncology, Janssen, Merck/MSD, and Roche; has participated in speaker bureaus for AstraZeneca, Pfizer, Janssen, Sanofi, and Astellas Pharma; and has received research funding from AstraZeneca and Pfizer Oncology through grants to his institution.WileyInstitut Català de la Salut[Gonzalez D] Patrick G Johnston Centre for Cancer Research, Queen’s University, Belfast, UK. [Mateo J] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Stenzinger A] Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. [Rojo F] Department of Pathology, IIS-Hospital Universitario Fundación Jiménez Díaz-CIBERONC, Madrid, Spain. [Shiller M] Department of Pathology, Baylor University Medical Center, Dallas, TX, USA. [Wyatt AW] Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, CanadaVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7157Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésThe Journal of Pathology: Clinical Research;7(4)https://doi.org/10.1002/cjp2.203Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/71572026-06-12T09:38:37Z |
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15,81155 |