The global distribution and environmental drivers of the soil antibiotic resistome

Background Little is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth’s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications fo...

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Detalles Bibliográficos
Autores: Delgado-Baquerizo, Manuel, Hu, Hang-Wei, Maestre, Fernando, Guerra, Carlos, Eisenhauer, Nico, Eldridge, David, Zhu, Yong-Guan, Chen, Qing-Lin, Trivedi, Pankaj, Du, Shuai, Makhalanyane, Thulani, Verma, Jay Prakash, Gozalo, Beatriz, Ochoa, Victoria, Asensio, Sergio, Wang, Ling, Zaady, Eli, Illán, Javier, Siebe, Christina, Grebenc, Tine, Zhou, Xiaobing, Liu, Yu-Rong, Bamigboye, Adebola, Blanco-Pastor, José, Duran, Jorge, Rodríguez, Alexandra, Mamet, Steven, Alfaro, Fernando, Abades, Sebastian, López Teixido, Alberto, Peñaloza-Bojacá, Gabriel, Molina-Montenegro, Marco, Torres-Díaz, Cristian, Pérez, Cecilia, Gallardo, Antonio, García-Velázquez, Laura, Hayes, Patrick, Neuhauser, Sigrid, He, Ji-Zheng
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/94542
Acceso en línea:https://hdl.handle.net/20.500.14352/94542
Access Level:acceso abierto
Palabra clave:631.4
Antibiotic resistance
Global scale
Mobile genetic elements
Human health
Global change
Genética
Ecología (Biología)
Edafología (Biología)
2417.14 Genética Vegetal
2511.02 Biología de Suelos
Descripción
Sumario:Background Little is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth’s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs. Results We show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs. Conclusions Together, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome.

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