Fatty acid metabolism and the basis of brown adipose tissue function

Obesity has reached epidemic proportions, leading to severe associated pathologies such as insulin resistance, cardiovascular disease, cancer and type 2 diabetes. Adipose tissue has become crucial due to its involvement in the pathogenesis of obesity-induced insulin resistance, and traditionally whi...

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Authors: Calderón Domínguez, María, Mir Bonnín, Joan Francesc, Fucho Salvador, Raquel, Weber Blattes, Minéia, Serra i Cucurull, Dolors, Herrero Rodríguez, Laura
Format: article
Status:Published version
Publication Date:2016
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/168554
Online Access:https://hdl.handle.net/2445/168554
Access Level:Open access
Keyword:Obesitat
Metabolisme dels lípids
Obesity
Lipid metabolism
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spelling Fatty acid metabolism and the basis of brown adipose tissue functionCalderón Domínguez, MaríaMir Bonnín, Joan FrancescFucho Salvador, RaquelWeber Blattes, MinéiaSerra i Cucurull, DolorsHerrero Rodríguez, LauraObesitatMetabolisme dels lípidsObesityLipid metabolismObesity has reached epidemic proportions, leading to severe associated pathologies such as insulin resistance, cardiovascular disease, cancer and type 2 diabetes. Adipose tissue has become crucial due to its involvement in the pathogenesis of obesity-induced insulin resistance, and traditionally white adipose tissue has captured the most attention. However in the last decade the presence and activity of heat-generating brown adipose tissue (BAT) in adult humans has been rediscovered. BAT decreases with age and in obese and diabetic patients. It has thus attracted strong scientific interest, and any strategy to increase its mass or activity might lead to new therapeutic approaches to obesity and associated metabolic diseases. In this review we highlight the mechanisms of fatty acid uptake, trafficking and oxidation in brown fat thermogenesis. We focus on BAT's morphological and functional characteristics and fatty acid synthesis, storage, oxidation and use as a source of energy.Taylor and Francis2020202020162020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion21 p.application/pdfhttps://hdl.handle.net/2445/168554Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1080/21623945.2015.1122857Adipocyte, 2016, vol. 5, num. 2, p. 98-118https://doi.org/10.1080/21623945.2015.1122857cc-by (c) Calderón Domínguez, María et al., 2016http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1685542026-05-29T05:05:01Z
dc.title.none.fl_str_mv Fatty acid metabolism and the basis of brown adipose tissue function
title Fatty acid metabolism and the basis of brown adipose tissue function
spellingShingle Fatty acid metabolism and the basis of brown adipose tissue function
Calderón Domínguez, María
Obesitat
Metabolisme dels lípids
Obesity
Lipid metabolism
title_short Fatty acid metabolism and the basis of brown adipose tissue function
title_full Fatty acid metabolism and the basis of brown adipose tissue function
title_fullStr Fatty acid metabolism and the basis of brown adipose tissue function
title_full_unstemmed Fatty acid metabolism and the basis of brown adipose tissue function
title_sort Fatty acid metabolism and the basis of brown adipose tissue function
dc.creator.none.fl_str_mv Calderón Domínguez, María
Mir Bonnín, Joan Francesc
Fucho Salvador, Raquel
Weber Blattes, Minéia
Serra i Cucurull, Dolors
Herrero Rodríguez, Laura
author Calderón Domínguez, María
author_facet Calderón Domínguez, María
Mir Bonnín, Joan Francesc
Fucho Salvador, Raquel
Weber Blattes, Minéia
Serra i Cucurull, Dolors
Herrero Rodríguez, Laura
author_role author
author2 Mir Bonnín, Joan Francesc
Fucho Salvador, Raquel
Weber Blattes, Minéia
Serra i Cucurull, Dolors
Herrero Rodríguez, Laura
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Obesitat
Metabolisme dels lípids
Obesity
Lipid metabolism
topic Obesitat
Metabolisme dels lípids
Obesity
Lipid metabolism
description Obesity has reached epidemic proportions, leading to severe associated pathologies such as insulin resistance, cardiovascular disease, cancer and type 2 diabetes. Adipose tissue has become crucial due to its involvement in the pathogenesis of obesity-induced insulin resistance, and traditionally white adipose tissue has captured the most attention. However in the last decade the presence and activity of heat-generating brown adipose tissue (BAT) in adult humans has been rediscovered. BAT decreases with age and in obese and diabetic patients. It has thus attracted strong scientific interest, and any strategy to increase its mass or activity might lead to new therapeutic approaches to obesity and associated metabolic diseases. In this review we highlight the mechanisms of fatty acid uptake, trafficking and oxidation in brown fat thermogenesis. We focus on BAT's morphological and functional characteristics and fatty acid synthesis, storage, oxidation and use as a source of energy.
publishDate 2016
dc.date.none.fl_str_mv 2016
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/168554
url https://hdl.handle.net/2445/168554
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1080/21623945.2015.1122857
Adipocyte, 2016, vol. 5, num. 2, p. 98-118
https://doi.org/10.1080/21623945.2015.1122857
dc.rights.none.fl_str_mv cc-by (c) Calderón Domínguez, María et al., 2016
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Calderón Domínguez, María et al., 2016
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 21 p.
application/pdf
dc.publisher.none.fl_str_mv Taylor and Francis
publisher.none.fl_str_mv Taylor and Francis
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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