Detection of Relevant Heavy Metal Concentrations in Human Placental Tissue: Relationship between the Concentrations of Hg, As, Pb and Cd and the Diet of the Pregnant Woman.

Molina-Mesa, Soledad; Martínez-Cendán, Juan Pedro; Moyano-Rubiales, Daniel; Cubillas-Rodríguez, Inmaculada; Molina-García, Jorge; González-Mesa, Ernesto

Detection of Relevant Heavy Metal Concentrations in Human Placental Tissue: Relationship between the Concentrations of Hg, As, Pb and Cd and the Diet of the Pregnant Woman.

Heavy metals can cross the placental barrier and reach the fetal compartment, threatening fetal development. Pregnant women can acquire these through food, drinking water, toxic habits or simply by breathing polluted air. The placenta has been described as a biomarker of maternal and fetal exposure...

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Autores:	Molina-Mesa, Soledad, Martínez-Cendán, Juan Pedro, Moyano-Rubiales, Daniel, Cubillas-Rodríguez, Inmaculada, Molina-García, Jorge, González-Mesa, Ernesto
Tipo de recurso:	artículo
Fecha de publicación:	2022
País:	España
Institución:	Instituto de Salud Carlos III (ISCIII)
Repositorio:	Repisalud
Idioma:	inglés
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/18850
Acceso en línea:	http://hdl.handle.net/20.500.12105/18850
Access Level:	acceso abierto
Palabra clave:	arsenic cadmium contaminants dietary habits heavy metals lead mercury placenta pregnancy toxicity Female Humans Infant, Newborn Pregnancy Pregnant Women Cadmium Lead Placenta Metals, Heavy Mercury Diet

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spelling	Detection of Relevant Heavy Metal Concentrations in Human Placental Tissue: Relationship between the Concentrations of Hg, As, Pb and Cd and the Diet of the Pregnant Woman.Molina-Mesa, SoledadMartínez-Cendán, Juan PedroMoyano-Rubiales, DanielCubillas-Rodríguez, InmaculadaMolina-García, JorgeGonzález-Mesa, Ernestoarseniccadmiumcontaminantsdietary habitsheavy metalsleadmercuryplacentapregnancytoxicityFemaleHumansInfant, NewbornPregnancyPregnant WomenCadmiumLeadPlacentaMetals, HeavyMercuryDietHeavy metals can cross the placental barrier and reach the fetal compartment, threatening fetal development. Pregnant women can acquire these through food, drinking water, toxic habits or simply by breathing polluted air. The placenta has been described as a biomarker of maternal and fetal exposure to different toxic elements. Objectives: The main objective of this study was to test the possible existence of heavy metal deposits (Pb, As, Cd and Hg) in the placentas of women who gave birth at term in our setting, analyzing the influence of daily life and dietary habits. Methods: We studied 103 placentas, obtained by consecutive sampling, of women that delivered in the Regional Maternity Hospital of Malaga between March and June, 2021. As, Cd and Pb concentrations were analyzed using mass spectrometry techniques. Hg concentration was studied according to US EPA method 7473. Women also answered a questionnaire with epidemiological variables. Results: Detectable concentrations were found in 14.56% [As], 44.6% [Cd], 81.5% [Pb] and 100% [Hg]. [Pb] and [As] correlated significantly (Spearman's Rho of 0.91 and <0.001), as did [Hg] and [Cd] (Spearman's Rho 0.256, p < 0.004). The [Pb] and [AS] concentrations were significantly higher in cases of tap water consumption. [Hg] concentrations predicted the birth weight of female newborns.20242024-02-2720222022-11-0920222022-11-09research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/18850reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/188502026-06-12T12:43:37Z
dc.title.none.fl_str_mv	Detection of Relevant Heavy Metal Concentrations in Human Placental Tissue: Relationship between the Concentrations of Hg, As, Pb and Cd and the Diet of the Pregnant Woman.
title	Detection of Relevant Heavy Metal Concentrations in Human Placental Tissue: Relationship between the Concentrations of Hg, As, Pb and Cd and the Diet of the Pregnant Woman.
spellingShingle	Detection of Relevant Heavy Metal Concentrations in Human Placental Tissue: Relationship between the Concentrations of Hg, As, Pb and Cd and the Diet of the Pregnant Woman. Molina-Mesa, Soledad arsenic cadmium contaminants dietary habits heavy metals lead mercury placenta pregnancy toxicity Female Humans Infant, Newborn Pregnancy Pregnant Women Cadmium Lead Placenta Metals, Heavy Mercury Diet
title_short	Detection of Relevant Heavy Metal Concentrations in Human Placental Tissue: Relationship between the Concentrations of Hg, As, Pb and Cd and the Diet of the Pregnant Woman.
title_full	Detection of Relevant Heavy Metal Concentrations in Human Placental Tissue: Relationship between the Concentrations of Hg, As, Pb and Cd and the Diet of the Pregnant Woman.
title_fullStr	Detection of Relevant Heavy Metal Concentrations in Human Placental Tissue: Relationship between the Concentrations of Hg, As, Pb and Cd and the Diet of the Pregnant Woman.
title_full_unstemmed	Detection of Relevant Heavy Metal Concentrations in Human Placental Tissue: Relationship between the Concentrations of Hg, As, Pb and Cd and the Diet of the Pregnant Woman.
title_sort	Detection of Relevant Heavy Metal Concentrations in Human Placental Tissue: Relationship between the Concentrations of Hg, As, Pb and Cd and the Diet of the Pregnant Woman.
dc.creator.none.fl_str_mv	Molina-Mesa, Soledad Martínez-Cendán, Juan Pedro Moyano-Rubiales, Daniel Cubillas-Rodríguez, Inmaculada Molina-García, Jorge González-Mesa, Ernesto
author	Molina-Mesa, Soledad
author_facet	Molina-Mesa, Soledad Martínez-Cendán, Juan Pedro Moyano-Rubiales, Daniel Cubillas-Rodríguez, Inmaculada Molina-García, Jorge González-Mesa, Ernesto
author_role	author
author2	Martínez-Cendán, Juan Pedro Moyano-Rubiales, Daniel Cubillas-Rodríguez, Inmaculada Molina-García, Jorge González-Mesa, Ernesto
author2_role	author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	arsenic cadmium contaminants dietary habits heavy metals lead mercury placenta pregnancy toxicity Female Humans Infant, Newborn Pregnancy Pregnant Women Cadmium Lead Placenta Metals, Heavy Mercury Diet
topic	arsenic cadmium contaminants dietary habits heavy metals lead mercury placenta pregnancy toxicity Female Humans Infant, Newborn Pregnancy Pregnant Women Cadmium Lead Placenta Metals, Heavy Mercury Diet
description	Heavy metals can cross the placental barrier and reach the fetal compartment, threatening fetal development. Pregnant women can acquire these through food, drinking water, toxic habits or simply by breathing polluted air. The placenta has been described as a biomarker of maternal and fetal exposure to different toxic elements. Objectives: The main objective of this study was to test the possible existence of heavy metal deposits (Pb, As, Cd and Hg) in the placentas of women who gave birth at term in our setting, analyzing the influence of daily life and dietary habits. Methods: We studied 103 placentas, obtained by consecutive sampling, of women that delivered in the Regional Maternity Hospital of Malaga between March and June, 2021. As, Cd and Pb concentrations were analyzed using mass spectrometry techniques. Hg concentration was studied according to US EPA method 7473. Women also answered a questionnaire with epidemiological variables. Results: Detectable concentrations were found in 14.56% [As], 44.6% [Cd], 81.5% [Pb] and 100% [Hg]. [Pb] and [As] correlated significantly (Spearman's Rho of 0.91 and <0.001), as did [Hg] and [Cd] (Spearman's Rho 0.256, p < 0.004). The [Pb] and [AS] concentrations were significantly higher in cases of tap water consumption. [Hg] concentrations predicted the birth weight of female newborns.
publishDate	2022
dc.date.none.fl_str_mv	2022 2022-11-09 2022 2022-11-09 2024 2024-02-27
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.12105/18850
url	http://hdl.handle.net/20.500.12105/18850
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
reponame_str	Repisalud
collection	Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,812429

Detection of Relevant Heavy Metal Concentrations in Human Placental Tissue: Relationship between the Concentrations of Hg, As, Pb and Cd and the Diet of the Pregnant Woman.

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