Characteristics and Outcomes in Patients with Ventilator-Associated Pneumonia Who Do or Do Not Develop Acute Respiratory Distress Syndrome. An Observational Study

Ventilator-associated pneumonia (VAP) is a well-known complication of patients on invasive mechanical ventilation. The main cause of acute respiratory distress syndrome (ARDS) is pneumonia. ARDS can occur in patients with community-acquired or nosocomial pneumonia. Data regarding ARDS incidence, rel...

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Autores: Barbeta, Enric|||0000-0001-9725-4100, Ceccato, Adrian|||0000-0001-9454-062X, Artigas Raventós, Antoni|||0000-0002-8029-1017, Ferrer, Miquel|||0000-0001-5880-3402, Fernández Barat, Laia|||0000-0001-7528-9636, López, Rubén, Bueno, Leticia, Motos, Ana|||0000-0002-3757-1232, Li Bassi, Gianluigi, Mellado Artigas, Ricard|||0000-0003-2815-6819, Ferrando, Carlos|||0000-0002-1907-5323, Palomeque, Andrea Catalina, Panigada, Mauro, Gabarrús, Albert|||0000-0003-3492-1310, De Mendoza, Diego, Torres, Antoni|||0000-0002-8643-2167
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:253048
Acceso en línea:https://ddd.uab.cat/record/253048
https://dx.doi.org/urn:doi:10.3390/jcm9113508
Access Level:acceso abierto
Palabra clave:Ventilator-associated pneumonia
Acute respiratory distress syndrome
Epidemiology
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spelling Characteristics and Outcomes in Patients with Ventilator-Associated Pneumonia Who Do or Do Not Develop Acute Respiratory Distress Syndrome. An Observational StudyBarbeta, Enric|||0000-0001-9725-4100Ceccato, Adrian|||0000-0001-9454-062XArtigas Raventós, Antoni|||0000-0002-8029-1017Ferrer, Miquel|||0000-0001-5880-3402Fernández Barat, Laia|||0000-0001-7528-9636López, RubénBueno, LeticiaMotos, Ana|||0000-0002-3757-1232Li Bassi, GianluigiMellado Artigas, Ricard|||0000-0003-2815-6819Ferrando, Carlos|||0000-0002-1907-5323Palomeque, Andrea CatalinaPanigada, MauroGabarrús, Albert|||0000-0003-3492-1310De Mendoza, DiegoTorres, Antoni|||0000-0002-8643-2167Ventilator-associated pneumoniaAcute respiratory distress syndromeEpidemiologyVentilator-associated pneumonia (VAP) is a well-known complication of patients on invasive mechanical ventilation. The main cause of acute respiratory distress syndrome (ARDS) is pneumonia. ARDS can occur in patients with community-acquired or nosocomial pneumonia. Data regarding ARDS incidence, related pathogens, and specific outcomes in patients with VAP is limited. This is a cohort study in which patients with VAP were evaluated in an 800-bed tertiary teaching hospital between 2004 and 2016. Clinical outcomes, microbiological and epidemiological data were assessed among those who developed ARDS and those who did not. Forty-one (13.6%) out of 301 VAP patients developed ARDS. Patients who developed ARDS were younger and presented with higher prevalence of chronic liver disease. Pseudomonas aeruginosa was the most frequently isolated pathogen, but without any difference between groups. Appropriate empirical antibiotic treatment was prescribed to ARDS patients as frequently as to those without ARDS. Ninety-day mortality did not significantly vary among patients with or without ARDS. Additionally, patients with ARDS did not have significantly higher intensive care unit (ICU) and 28-day mortality, ICU, and hospital length of stay, ventilation-free days, and duration of mechanical ventilation. In summary, ARDS deriving from VAP occurs in 13.6% of patients. Although significant differences in clinical outcomes were not observed between both groups, further studies with a higher number of patients are needed due to the possibility of the study being underpowered.Universitat Autònoma de Barcelona 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/253048https://dx.doi.org/urn:doi:10.3390/jcm9113508reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2530482026-06-06T12:50:31Z
dc.title.none.fl_str_mv Characteristics and Outcomes in Patients with Ventilator-Associated Pneumonia Who Do or Do Not Develop Acute Respiratory Distress Syndrome. An Observational Study
title Characteristics and Outcomes in Patients with Ventilator-Associated Pneumonia Who Do or Do Not Develop Acute Respiratory Distress Syndrome. An Observational Study
spellingShingle Characteristics and Outcomes in Patients with Ventilator-Associated Pneumonia Who Do or Do Not Develop Acute Respiratory Distress Syndrome. An Observational Study
Barbeta, Enric|||0000-0001-9725-4100
Ventilator-associated pneumonia
Acute respiratory distress syndrome
Epidemiology
title_short Characteristics and Outcomes in Patients with Ventilator-Associated Pneumonia Who Do or Do Not Develop Acute Respiratory Distress Syndrome. An Observational Study
title_full Characteristics and Outcomes in Patients with Ventilator-Associated Pneumonia Who Do or Do Not Develop Acute Respiratory Distress Syndrome. An Observational Study
title_fullStr Characteristics and Outcomes in Patients with Ventilator-Associated Pneumonia Who Do or Do Not Develop Acute Respiratory Distress Syndrome. An Observational Study
title_full_unstemmed Characteristics and Outcomes in Patients with Ventilator-Associated Pneumonia Who Do or Do Not Develop Acute Respiratory Distress Syndrome. An Observational Study
title_sort Characteristics and Outcomes in Patients with Ventilator-Associated Pneumonia Who Do or Do Not Develop Acute Respiratory Distress Syndrome. An Observational Study
dc.creator.none.fl_str_mv Barbeta, Enric|||0000-0001-9725-4100
Ceccato, Adrian|||0000-0001-9454-062X
Artigas Raventós, Antoni|||0000-0002-8029-1017
Ferrer, Miquel|||0000-0001-5880-3402
Fernández Barat, Laia|||0000-0001-7528-9636
López, Rubén
Bueno, Leticia
Motos, Ana|||0000-0002-3757-1232
Li Bassi, Gianluigi
Mellado Artigas, Ricard|||0000-0003-2815-6819
Ferrando, Carlos|||0000-0002-1907-5323
Palomeque, Andrea Catalina
Panigada, Mauro
Gabarrús, Albert|||0000-0003-3492-1310
De Mendoza, Diego
Torres, Antoni|||0000-0002-8643-2167
author Barbeta, Enric|||0000-0001-9725-4100
author_facet Barbeta, Enric|||0000-0001-9725-4100
Ceccato, Adrian|||0000-0001-9454-062X
Artigas Raventós, Antoni|||0000-0002-8029-1017
Ferrer, Miquel|||0000-0001-5880-3402
Fernández Barat, Laia|||0000-0001-7528-9636
López, Rubén
Bueno, Leticia
Motos, Ana|||0000-0002-3757-1232
Li Bassi, Gianluigi
Mellado Artigas, Ricard|||0000-0003-2815-6819
Ferrando, Carlos|||0000-0002-1907-5323
Palomeque, Andrea Catalina
Panigada, Mauro
Gabarrús, Albert|||0000-0003-3492-1310
De Mendoza, Diego
Torres, Antoni|||0000-0002-8643-2167
author_role author
author2 Ceccato, Adrian|||0000-0001-9454-062X
Artigas Raventós, Antoni|||0000-0002-8029-1017
Ferrer, Miquel|||0000-0001-5880-3402
Fernández Barat, Laia|||0000-0001-7528-9636
López, Rubén
Bueno, Leticia
Motos, Ana|||0000-0002-3757-1232
Li Bassi, Gianluigi
Mellado Artigas, Ricard|||0000-0003-2815-6819
Ferrando, Carlos|||0000-0002-1907-5323
Palomeque, Andrea Catalina
Panigada, Mauro
Gabarrús, Albert|||0000-0003-3492-1310
De Mendoza, Diego
Torres, Antoni|||0000-0002-8643-2167
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Ventilator-associated pneumonia
Acute respiratory distress syndrome
Epidemiology
topic Ventilator-associated pneumonia
Acute respiratory distress syndrome
Epidemiology
description Ventilator-associated pneumonia (VAP) is a well-known complication of patients on invasive mechanical ventilation. The main cause of acute respiratory distress syndrome (ARDS) is pneumonia. ARDS can occur in patients with community-acquired or nosocomial pneumonia. Data regarding ARDS incidence, related pathogens, and specific outcomes in patients with VAP is limited. This is a cohort study in which patients with VAP were evaluated in an 800-bed tertiary teaching hospital between 2004 and 2016. Clinical outcomes, microbiological and epidemiological data were assessed among those who developed ARDS and those who did not. Forty-one (13.6%) out of 301 VAP patients developed ARDS. Patients who developed ARDS were younger and presented with higher prevalence of chronic liver disease. Pseudomonas aeruginosa was the most frequently isolated pathogen, but without any difference between groups. Appropriate empirical antibiotic treatment was prescribed to ARDS patients as frequently as to those without ARDS. Ninety-day mortality did not significantly vary among patients with or without ARDS. Additionally, patients with ARDS did not have significantly higher intensive care unit (ICU) and 28-day mortality, ICU, and hospital length of stay, ventilation-free days, and duration of mechanical ventilation. In summary, ARDS deriving from VAP occurs in 13.6% of patients. Although significant differences in clinical outcomes were not observed between both groups, further studies with a higher number of patients are needed due to the possibility of the study being underpowered.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/253048
https://dx.doi.org/urn:doi:10.3390/jcm9113508
url https://ddd.uab.cat/record/253048
https://dx.doi.org/urn:doi:10.3390/jcm9113508
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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