Pneumonia in children admitted to the national referral hospital in Bhutan: a prospective cohort study

Objectives The study aim was to describe the etiological profile and clinical characteristics of pneumonia among children hospitalized in Thimphu, Bhutan. Methods This prospective study enrolled children aged 2–59 months admitted to the Jigme Dorji Wangchuck National Referral Hospital with World Hea...

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Autores: Jullien, Sophie, Pradhan, Dinesh, Tshering, Tashi, Sharma, Ragunath, Dema, Kumbu, García García, Selene, Ribó Aristizabal, José L., Muñoz-Almagro, Carmen, Bassat Orellana, Quique
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/161061
Acceso en línea:https://hdl.handle.net/2445/161061
Access Level:acceso abierto
Palabra clave:Pneumònia
Infants
Bhutan
Pneumonia
Children
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spelling Pneumonia in children admitted to the national referral hospital in Bhutan: a prospective cohort studyJullien, SophiePradhan, DineshTshering, TashiSharma, RagunathDema, KumbuGarcía García, SeleneRibó Aristizabal, José L.Muñoz-Almagro, CarmenBassat Orellana, QuiquePneumòniaInfantsBhutanPneumoniaChildrenBhutanObjectives The study aim was to describe the etiological profile and clinical characteristics of pneumonia among children hospitalized in Thimphu, Bhutan. Methods This prospective study enrolled children aged 2–59 months admitted to the Jigme Dorji Wangchuck National Referral Hospital with World Health Organization (WHO)-defined clinical pneumonia. Demographic and clinico-radiological data were collected through questionnaires, physical examination, and chest radiography. Blood samples and nasopharyngeal washing were collected for microbiological analysis including culture and molecular methods. Results From July 2017 to June 2018, 189 children were enrolled, of which 53.4% were infants. Pneumonia-related admissions were less frequent over the winter. Chest radiographies were obtained in 149 children; endpoints included pneumonia in 39 cases (26.2%), other infiltrates in 31 (20.8%), and were normal in 79 children (53.0%). Non-contaminated bacterial growth was detected in 8/152 (5.3%) blood cultures, with only two cases of Streptococcus pneumoniae. Viral detection in upper respiratory secretions was common, with at least one virus detected in 103/115 (89.6%). The three most-commonly isolated viruses were respiratory syncytial virus (52/115; 45.2%), rhinovirus (42/115; 36.5%), and human parainfluenza virus (19/115; 16.5%). A third of patients with viral infections showed mixed infections. Case fatality rate was 3.2% (6/189). Conclusion Respiratory viral infections predominated among this cohort of WHO-defined clinical pneumonia cases, whereas bacterial aetiologies were uncommon, highlighting the epidemiologic transition that Bhutan seems to have reached.Elsevier2020202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/161061Articles publicats en revistes (ISGlobal)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.ijid.2020.04.017International Journal of Infectious Diseases , 2020 , vol. 95 , num. , p. 9https://doi.org/10.1016/j.ijid.2020.04.017cc-by-nc-nd (c) Julien et al., 2020http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1610612026-05-29T05:05:01Z
dc.title.none.fl_str_mv Pneumonia in children admitted to the national referral hospital in Bhutan: a prospective cohort study
title Pneumonia in children admitted to the national referral hospital in Bhutan: a prospective cohort study
spellingShingle Pneumonia in children admitted to the national referral hospital in Bhutan: a prospective cohort study
Jullien, Sophie
Pneumònia
Infants
Bhutan
Pneumonia
Children
Bhutan
title_short Pneumonia in children admitted to the national referral hospital in Bhutan: a prospective cohort study
title_full Pneumonia in children admitted to the national referral hospital in Bhutan: a prospective cohort study
title_fullStr Pneumonia in children admitted to the national referral hospital in Bhutan: a prospective cohort study
title_full_unstemmed Pneumonia in children admitted to the national referral hospital in Bhutan: a prospective cohort study
title_sort Pneumonia in children admitted to the national referral hospital in Bhutan: a prospective cohort study
dc.creator.none.fl_str_mv Jullien, Sophie
Pradhan, Dinesh
Tshering, Tashi
Sharma, Ragunath
Dema, Kumbu
García García, Selene
Ribó Aristizabal, José L.
Muñoz-Almagro, Carmen
Bassat Orellana, Quique
author Jullien, Sophie
author_facet Jullien, Sophie
Pradhan, Dinesh
Tshering, Tashi
Sharma, Ragunath
Dema, Kumbu
García García, Selene
Ribó Aristizabal, José L.
Muñoz-Almagro, Carmen
Bassat Orellana, Quique
author_role author
author2 Pradhan, Dinesh
Tshering, Tashi
Sharma, Ragunath
Dema, Kumbu
García García, Selene
Ribó Aristizabal, José L.
Muñoz-Almagro, Carmen
Bassat Orellana, Quique
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pneumònia
Infants
Bhutan
Pneumonia
Children
Bhutan
topic Pneumònia
Infants
Bhutan
Pneumonia
Children
Bhutan
description Objectives The study aim was to describe the etiological profile and clinical characteristics of pneumonia among children hospitalized in Thimphu, Bhutan. Methods This prospective study enrolled children aged 2–59 months admitted to the Jigme Dorji Wangchuck National Referral Hospital with World Health Organization (WHO)-defined clinical pneumonia. Demographic and clinico-radiological data were collected through questionnaires, physical examination, and chest radiography. Blood samples and nasopharyngeal washing were collected for microbiological analysis including culture and molecular methods. Results From July 2017 to June 2018, 189 children were enrolled, of which 53.4% were infants. Pneumonia-related admissions were less frequent over the winter. Chest radiographies were obtained in 149 children; endpoints included pneumonia in 39 cases (26.2%), other infiltrates in 31 (20.8%), and were normal in 79 children (53.0%). Non-contaminated bacterial growth was detected in 8/152 (5.3%) blood cultures, with only two cases of Streptococcus pneumoniae. Viral detection in upper respiratory secretions was common, with at least one virus detected in 103/115 (89.6%). The three most-commonly isolated viruses were respiratory syncytial virus (52/115; 45.2%), rhinovirus (42/115; 36.5%), and human parainfluenza virus (19/115; 16.5%). A third of patients with viral infections showed mixed infections. Case fatality rate was 3.2% (6/189). Conclusion Respiratory viral infections predominated among this cohort of WHO-defined clinical pneumonia cases, whereas bacterial aetiologies were uncommon, highlighting the epidemiologic transition that Bhutan seems to have reached.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/161061
url https://hdl.handle.net/2445/161061
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.ijid.2020.04.017
International Journal of Infectious Diseases , 2020 , vol. 95 , num. , p. 9
https://doi.org/10.1016/j.ijid.2020.04.017
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Julien et al., 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Julien et al., 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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