Cognitive intraindividual variability, cognitive impairment and psychosocial functioning in first-episode psychosis patients

Cognitive intraindividual variability (IIV) refers to fluctuations in performance across tasks (i.e. dispersion) or in a single task on multiple occasions (i.e. inconsistency). Little is known about IIV in patients with first-episode psychosis (FEP). We aimed to explore the association between IIV a...

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Authors: Sánchez Torres, Ana María, García de Jalón, Elena, Gil Berrozpe, Gustavo José, Peralta Martín, Víctor, Cuesta, Manuel J., PEPsNa Group
Format: article
Status:Versión aceptada para publicación
Publication Date:2023
Country:España
Institution:Universidad Pública de Navarra
Repository:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/51938
Online Access:https://hdl.handle.net/2454/51938
Access Level:Open access
Keyword:Cognitive intra-individual variability
Across tasks variability
First episode psychosis
Psychosocial functioning
Psychotic disorders
Cognition
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spelling Cognitive intraindividual variability, cognitive impairment and psychosocial functioning in first-episode psychosis patientsSánchez Torres, Ana MaríaGarcía de Jalón, ElenaGil Berrozpe, Gustavo JoséPeralta Martín, VíctorCuesta, Manuel J.PEPsNa GroupCognitive intra-individual variabilityAcross tasks variabilityFirst episode psychosisPsychosocial functioningPsychotic disordersCognitionCognitive intraindividual variability (IIV) refers to fluctuations in performance across tasks (i.e. dispersion) or in a single task on multiple occasions (i.e. inconsistency). Little is known about IIV in patients with first-episode psychosis (FEP). We aimed to explore the association between IIV and both global cognitive performance and psychosocial functioning in a sample of 103 FEP patients. Patients were recruited at discharge from the PEPsNa program, a FEP follow-up intervention program lasting 24 months. The Social and Occupational Functioning Scale (SOFAS) and the Cognitive Assessment Interview (CAI-Sp) were employed for assessing psychosocial functioning. Cognitive assessments were performed using the MATRICS Cognitive Assessment Battery (MCCB), and the variability in the cognitive functions assessed with the MCCB was used to calculate the IIV. Significant correlations were obtained between IIV and global MCCB scores, the CAI-Sp and the SOFAS. We found significant differences in psychosocial functioning and cognitive performance between patients with high and low IIV. A higher IIV in FEP patients was related both to worse psychosocial functioning and worse global cognitive performance. Unlike global cognitive performance, IIV was not related to clinical characteristics, suggesting that it could be an indicator of cognitive impairment even in the absence of global impairment.This work was funded by the Instituto de Salud Carlos III, the Spanish Ministry of Science, Innovation and Universities, the European Regional Development Fund (ERDF/FEDER) (PI 19/01968) and the Departamento de Salud del Gobierno de Navarra (20/21).ElsevierCiencias de la SaludOsasun Zientziak2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2454/51938reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglés© 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/519382026-06-17T12:41:47Z
dc.title.none.fl_str_mv Cognitive intraindividual variability, cognitive impairment and psychosocial functioning in first-episode psychosis patients
title Cognitive intraindividual variability, cognitive impairment and psychosocial functioning in first-episode psychosis patients
spellingShingle Cognitive intraindividual variability, cognitive impairment and psychosocial functioning in first-episode psychosis patients
Sánchez Torres, Ana María
Cognitive intra-individual variability
Across tasks variability
First episode psychosis
Psychosocial functioning
Psychotic disorders
Cognition
title_short Cognitive intraindividual variability, cognitive impairment and psychosocial functioning in first-episode psychosis patients
title_full Cognitive intraindividual variability, cognitive impairment and psychosocial functioning in first-episode psychosis patients
title_fullStr Cognitive intraindividual variability, cognitive impairment and psychosocial functioning in first-episode psychosis patients
title_full_unstemmed Cognitive intraindividual variability, cognitive impairment and psychosocial functioning in first-episode psychosis patients
title_sort Cognitive intraindividual variability, cognitive impairment and psychosocial functioning in first-episode psychosis patients
dc.creator.none.fl_str_mv Sánchez Torres, Ana María
García de Jalón, Elena
Gil Berrozpe, Gustavo José
Peralta Martín, Víctor
Cuesta, Manuel J.
PEPsNa Group
author Sánchez Torres, Ana María
author_facet Sánchez Torres, Ana María
García de Jalón, Elena
Gil Berrozpe, Gustavo José
Peralta Martín, Víctor
Cuesta, Manuel J.
PEPsNa Group
author_role author
author2 García de Jalón, Elena
Gil Berrozpe, Gustavo José
Peralta Martín, Víctor
Cuesta, Manuel J.
PEPsNa Group
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ciencias de la Salud
Osasun Zientziak
dc.subject.none.fl_str_mv Cognitive intra-individual variability
Across tasks variability
First episode psychosis
Psychosocial functioning
Psychotic disorders
Cognition
topic Cognitive intra-individual variability
Across tasks variability
First episode psychosis
Psychosocial functioning
Psychotic disorders
Cognition
description Cognitive intraindividual variability (IIV) refers to fluctuations in performance across tasks (i.e. dispersion) or in a single task on multiple occasions (i.e. inconsistency). Little is known about IIV in patients with first-episode psychosis (FEP). We aimed to explore the association between IIV and both global cognitive performance and psychosocial functioning in a sample of 103 FEP patients. Patients were recruited at discharge from the PEPsNa program, a FEP follow-up intervention program lasting 24 months. The Social and Occupational Functioning Scale (SOFAS) and the Cognitive Assessment Interview (CAI-Sp) were employed for assessing psychosocial functioning. Cognitive assessments were performed using the MATRICS Cognitive Assessment Battery (MCCB), and the variability in the cognitive functions assessed with the MCCB was used to calculate the IIV. Significant correlations were obtained between IIV and global MCCB scores, the CAI-Sp and the SOFAS. We found significant differences in psychosocial functioning and cognitive performance between patients with high and low IIV. A higher IIV in FEP patients was related both to worse psychosocial functioning and worse global cognitive performance. Unlike global cognitive performance, IIV was not related to clinical characteristics, suggesting that it could be an indicator of cognitive impairment even in the absence of global impairment.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/51938
url https://hdl.handle.net/2454/51938
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv © 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
repository.name.fl_str_mv
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