Evaluation of Polysaccharide Typhim Vi Antibody Response as a predictor of Humoral Immunodeficiency in Haematological Malignancies

An increasing healthcare challenge in the management of haematological malignancy (HM) is secondary immunodeficiency. From January 2019, the EMA included the evaluation of specific antibody (Ab) responses to better select patients for immunoglobulin replacement therapy (IgRT). We evaluated Ab respon...

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Detalles Bibliográficos
Autores: Ochoa-Grullón, Juliana, Benavente Cuesta, Celina, Pérez López, César, Peña Cortijo, Ascensión, Mateos-Aparicio Morales, Gregoria, Fernández Arquero, Miguel, Recio Hoyas, María José, Sánchez-Ramón, Silvia
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/92618
Acceso en línea:https://hdl.handle.net/20.500.14352/92618
Access Level:acceso abierto
Palabra clave:612.017
Haematological malignancies
Hypogammaglobulinemia
Pneumo23
Specific polysaccharide ab response
Typhim vi
Inmunología
2412 Inmunología
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repository_id_str
spelling Evaluation of Polysaccharide Typhim Vi Antibody Response as a predictor of Humoral Immunodeficiency in Haematological MalignanciesOchoa-Grullón, JulianaBenavente Cuesta, CelinaPérez López, CésarPeña Cortijo, AscensiónMateos-Aparicio Morales, GregoriaFernández Arquero, MiguelRecio Hoyas, María JoséSánchez-Ramón, Silvia612.017Haematological malignanciesHypogammaglobulinemiaPneumo23Specific polysaccharide ab responseTyphim viInmunología2412 InmunologíaAn increasing healthcare challenge in the management of haematological malignancy (HM) is secondary immunodeficiency. From January 2019, the EMA included the evaluation of specific antibody (Ab) responses to better select patients for immunoglobulin replacement therapy (IgRT). We evaluated Ab responses to pneumococcal and Salmonella typhi pure polysaccharide immunization in a cohort of 42 HM patients and 24 healthy-controls. Pre-post specific Ab concentrations were measured by ELISA at 4 weeks. Globally, significantly lower Typhim Vi (TV) seroprevalence (9%) compared to 23-valent pneumococcal polysaccharide vaccine (PPV) (76%) (p <0.001) was observed. TV non responders (88%) were higher than PPV non responders (62%) (p <0.0001) and correlated better to infectious history. By ROC analysis, pre-post 5-fold TV increase was the best cut-off to discriminate HM with recurrent infections and controls (sensitivity 91%, specificity 100%). Despite the small sample cohort, our results suggest that specific anti-S typhi Ab response is a useful complementary assay in the diagnosis and management decision of SID to HM.ACADEMIC PRESS INC ELSEVIER SCIENCEUniversidad Complutense de Madrid20202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/92618reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/926182026-06-02T12:44:21Z
dc.title.none.fl_str_mv Evaluation of Polysaccharide Typhim Vi Antibody Response as a predictor of Humoral Immunodeficiency in Haematological Malignancies
title Evaluation of Polysaccharide Typhim Vi Antibody Response as a predictor of Humoral Immunodeficiency in Haematological Malignancies
spellingShingle Evaluation of Polysaccharide Typhim Vi Antibody Response as a predictor of Humoral Immunodeficiency in Haematological Malignancies
Ochoa-Grullón, Juliana
612.017
Haematological malignancies
Hypogammaglobulinemia
Pneumo23
Specific polysaccharide ab response
Typhim vi
Inmunología
2412 Inmunología
title_short Evaluation of Polysaccharide Typhim Vi Antibody Response as a predictor of Humoral Immunodeficiency in Haematological Malignancies
title_full Evaluation of Polysaccharide Typhim Vi Antibody Response as a predictor of Humoral Immunodeficiency in Haematological Malignancies
title_fullStr Evaluation of Polysaccharide Typhim Vi Antibody Response as a predictor of Humoral Immunodeficiency in Haematological Malignancies
title_full_unstemmed Evaluation of Polysaccharide Typhim Vi Antibody Response as a predictor of Humoral Immunodeficiency in Haematological Malignancies
title_sort Evaluation of Polysaccharide Typhim Vi Antibody Response as a predictor of Humoral Immunodeficiency in Haematological Malignancies
dc.creator.none.fl_str_mv Ochoa-Grullón, Juliana
Benavente Cuesta, Celina
Pérez López, César
Peña Cortijo, Ascensión
Mateos-Aparicio Morales, Gregoria
Fernández Arquero, Miguel
Recio Hoyas, María José
Sánchez-Ramón, Silvia
author Ochoa-Grullón, Juliana
author_facet Ochoa-Grullón, Juliana
Benavente Cuesta, Celina
Pérez López, César
Peña Cortijo, Ascensión
Mateos-Aparicio Morales, Gregoria
Fernández Arquero, Miguel
Recio Hoyas, María José
Sánchez-Ramón, Silvia
author_role author
author2 Benavente Cuesta, Celina
Pérez López, César
Peña Cortijo, Ascensión
Mateos-Aparicio Morales, Gregoria
Fernández Arquero, Miguel
Recio Hoyas, María José
Sánchez-Ramón, Silvia
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 612.017
Haematological malignancies
Hypogammaglobulinemia
Pneumo23
Specific polysaccharide ab response
Typhim vi
Inmunología
2412 Inmunología
topic 612.017
Haematological malignancies
Hypogammaglobulinemia
Pneumo23
Specific polysaccharide ab response
Typhim vi
Inmunología
2412 Inmunología
description An increasing healthcare challenge in the management of haematological malignancy (HM) is secondary immunodeficiency. From January 2019, the EMA included the evaluation of specific antibody (Ab) responses to better select patients for immunoglobulin replacement therapy (IgRT). We evaluated Ab responses to pneumococcal and Salmonella typhi pure polysaccharide immunization in a cohort of 42 HM patients and 24 healthy-controls. Pre-post specific Ab concentrations were measured by ELISA at 4 weeks. Globally, significantly lower Typhim Vi (TV) seroprevalence (9%) compared to 23-valent pneumococcal polysaccharide vaccine (PPV) (76%) (p <0.001) was observed. TV non responders (88%) were higher than PPV non responders (62%) (p <0.0001) and correlated better to infectious history. By ROC analysis, pre-post 5-fold TV increase was the best cut-off to discriminate HM with recurrent infections and controls (sensitivity 91%, specificity 100%). Despite the small sample cohort, our results suggest that specific anti-S typhi Ab response is a useful complementary assay in the diagnosis and management decision of SID to HM.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/92618
url https://hdl.handle.net/20.500.14352/92618
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ACADEMIC PRESS INC ELSEVIER SCIENCE
publisher.none.fl_str_mv ACADEMIC PRESS INC ELSEVIER SCIENCE
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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