Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants

This is a narrative review about the mechanisms involved in bacterial sepsis in preterm infants, which is an illness with a high incidence, morbidity, and mortality. The role of the innate immune response and its relationship with oxidative stress in the pathogenesis are described as well as their p...

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Detalles Bibliográficos
Autores: Parra Llorca, Anna, Pinilla-González, Alejandro, Torrejón-Rodríguez, Laura, Lara-Cantón, Inmaculada, Kuligowski, Julia, Collado, María Carmen, Gormaz, María, Aguar, Marta, Vento, Máximo, Serna, Eva, Cernada, María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/305513
Acceso en línea:http://hdl.handle.net/10261/305513
Access Level:acceso abierto
Palabra clave:Sepsis
Preterm
Immune response
Oxidative stress
Microbiome
Descripción
Sumario:This is a narrative review about the mechanisms involved in bacterial sepsis in preterm infants, which is an illness with a high incidence, morbidity, and mortality. The role of the innate immune response and its relationship with oxidative stress in the pathogenesis are described as well as their potential implementation as early biomarkers. Moreover, we address the impact that all the mechanisms triggered by sepsis have on the dysbiosis and the changes on neonatal microbiota.