Cytocompatibility and antimicrobial properties of silver nanoparticle-decorated hydroxyapatite-coated TiMoNbTa alloy

Titanium and its alloys are widely used for implants, although they have limitations like higher elastic modulus compared to bone, causing stress shielding and potential implant failure. To address these issues, β-Ti alloys and calcium phosphate coatings are being developed to improve the mechanical...

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Autores: Escobar, Michael|||0000-0002-5813-3370, Turner, Adam Benedict|||0000-0002-4485-6738, Sort, Jordi|||0000-0003-1213-3639, Nogués, Carme|||0000-0002-6361-8559, Pellicer, Eva|||0000-0002-8901-0998, Blanquer, Andreu|||0000-0002-3551-1885, Trobos, Margarita|||0000-0002-9253-6771
Formato: artículo
Fecha de publicación:2025
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:318521
Acesso em linha:https://ddd.uab.cat/record/318521
https://dx.doi.org/urn:doi:10.1016/j.surfin.2025.106934
Access Level:acceso abierto
Palavra-chave:В-titanium alloys
Silver nanoparticles
Cytocompatibility
Human osteoblasts
Antibacterial activity
Staphylococcus aureus
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spelling Cytocompatibility and antimicrobial properties of silver nanoparticle-decorated hydroxyapatite-coated TiMoNbTa alloyEscobar, Michael|||0000-0002-5813-3370Turner, Adam Benedict|||0000-0002-4485-6738Sort, Jordi|||0000-0003-1213-3639Nogués, Carme|||0000-0002-6361-8559Pellicer, Eva|||0000-0002-8901-0998Blanquer, Andreu|||0000-0002-3551-1885Trobos, Margarita|||0000-0002-9253-6771В-titanium alloysSilver nanoparticlesCytocompatibilityHuman osteoblastsAntibacterial activityStaphylococcus aureusTitanium and its alloys are widely used for implants, although they have limitations like higher elastic modulus compared to bone, causing stress shielding and potential implant failure. To address these issues, β-Ti alloys and calcium phosphate coatings are being developed to improve the mechanical properties while enhancing bone integration. The risk of infection is another important limitation that can be addressed through the deposition of antibacterial and antibiofilm coatings on the alloys. Here, we present a β-Ti alloy (Ti-18Mo-6Nb-5Ta (wt %)) coated with calcium-deficient hydroxyapatite (CDHA) and decorated with silver nanoparticles intended to be used as antimicrobial orthopedic implants. The experiments revealed that human osteoblasts were able to adhere and proliferate on coating. The presence of silver nanoparticles did not adversely affect human osteoblast differentiation and led to a 50 % increase in type I collagen production. The coating decorated with silver nanoparticles exhibited a significant antibacterial effect against Staphylococcus aureus, reducing biofilm formation by over 40 % after 24 h compared to the undecorated coating. Taken together, these results show the effectiveness of the silver decorated CDHA coating in enhancing osteoblasts proliferation and differentiation while also reducing biofilm growth when compared to CDHA coating. 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/318521https://dx.doi.org/urn:doi:10.1016/j.surfin.2025.106934reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 861046Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-116844RB-C21Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2023-148047OA-C22Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00651Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00122open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3185212026-06-06T12:50:31Z
dc.title.none.fl_str_mv Cytocompatibility and antimicrobial properties of silver nanoparticle-decorated hydroxyapatite-coated TiMoNbTa alloy
title Cytocompatibility and antimicrobial properties of silver nanoparticle-decorated hydroxyapatite-coated TiMoNbTa alloy
spellingShingle Cytocompatibility and antimicrobial properties of silver nanoparticle-decorated hydroxyapatite-coated TiMoNbTa alloy
Escobar, Michael|||0000-0002-5813-3370
В-titanium alloys
Silver nanoparticles
Cytocompatibility
Human osteoblasts
Antibacterial activity
Staphylococcus aureus
title_short Cytocompatibility and antimicrobial properties of silver nanoparticle-decorated hydroxyapatite-coated TiMoNbTa alloy
title_full Cytocompatibility and antimicrobial properties of silver nanoparticle-decorated hydroxyapatite-coated TiMoNbTa alloy
title_fullStr Cytocompatibility and antimicrobial properties of silver nanoparticle-decorated hydroxyapatite-coated TiMoNbTa alloy
title_full_unstemmed Cytocompatibility and antimicrobial properties of silver nanoparticle-decorated hydroxyapatite-coated TiMoNbTa alloy
title_sort Cytocompatibility and antimicrobial properties of silver nanoparticle-decorated hydroxyapatite-coated TiMoNbTa alloy
dc.creator.none.fl_str_mv Escobar, Michael|||0000-0002-5813-3370
Turner, Adam Benedict|||0000-0002-4485-6738
Sort, Jordi|||0000-0003-1213-3639
Nogués, Carme|||0000-0002-6361-8559
Pellicer, Eva|||0000-0002-8901-0998
Blanquer, Andreu|||0000-0002-3551-1885
Trobos, Margarita|||0000-0002-9253-6771
author Escobar, Michael|||0000-0002-5813-3370
author_facet Escobar, Michael|||0000-0002-5813-3370
Turner, Adam Benedict|||0000-0002-4485-6738
Sort, Jordi|||0000-0003-1213-3639
Nogués, Carme|||0000-0002-6361-8559
Pellicer, Eva|||0000-0002-8901-0998
Blanquer, Andreu|||0000-0002-3551-1885
Trobos, Margarita|||0000-0002-9253-6771
author_role author
author2 Turner, Adam Benedict|||0000-0002-4485-6738
Sort, Jordi|||0000-0003-1213-3639
Nogués, Carme|||0000-0002-6361-8559
Pellicer, Eva|||0000-0002-8901-0998
Blanquer, Andreu|||0000-0002-3551-1885
Trobos, Margarita|||0000-0002-9253-6771
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv В-titanium alloys
Silver nanoparticles
Cytocompatibility
Human osteoblasts
Antibacterial activity
Staphylococcus aureus
topic В-titanium alloys
Silver nanoparticles
Cytocompatibility
Human osteoblasts
Antibacterial activity
Staphylococcus aureus
description Titanium and its alloys are widely used for implants, although they have limitations like higher elastic modulus compared to bone, causing stress shielding and potential implant failure. To address these issues, β-Ti alloys and calcium phosphate coatings are being developed to improve the mechanical properties while enhancing bone integration. The risk of infection is another important limitation that can be addressed through the deposition of antibacterial and antibiofilm coatings on the alloys. Here, we present a β-Ti alloy (Ti-18Mo-6Nb-5Ta (wt %)) coated with calcium-deficient hydroxyapatite (CDHA) and decorated with silver nanoparticles intended to be used as antimicrobial orthopedic implants. The experiments revealed that human osteoblasts were able to adhere and proliferate on coating. The presence of silver nanoparticles did not adversely affect human osteoblast differentiation and led to a 50 % increase in type I collagen production. The coating decorated with silver nanoparticles exhibited a significant antibacterial effect against Staphylococcus aureus, reducing biofilm formation by over 40 % after 24 h compared to the undecorated coating. Taken together, these results show the effectiveness of the silver decorated CDHA coating in enhancing osteoblasts proliferation and differentiation while also reducing biofilm growth when compared to CDHA coating.
publishDate 2025
dc.date.none.fl_str_mv 2
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/318521
https://dx.doi.org/urn:doi:10.1016/j.surfin.2025.106934
url https://ddd.uab.cat/record/318521
https://dx.doi.org/urn:doi:10.1016/j.surfin.2025.106934
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission https://doi.org/10.13039/501100000780 861046
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-116844RB-C21
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2023-148047OA-C22
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00651
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00122
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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