Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life

The immune system of newborns is underdeveloped, leaving them susceptible to infections like rotavirus (RV). Despite vaccines, RV remains a leading cause of child mortality, especially in developing countries. Maternal immunity is transferred during pregnancy and breastfeeding to the offspring provi...

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Autores: Sáez Fuertes, Laura, Rio Aige, Karla, Massot-Cladera, Malén, Castell, Margarida, Knipping, Karen, Garssen, Johan, Bourdet-Sicard, Raphaëlle, Rodríguez-Lagunas, María José, Collado, María Carmen, Pérez-Cano, Francisco José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/373845
Acceso en línea:http://hdl.handle.net/10261/373845
https://api.elsevier.com/content/abstract/scopus_id/85207343636
Access Level:acceso abierto
Palabra clave:Bifidobacterium breve M‐16V
Infancy
Long chain fructo‐oligosaccharides (lcFOS)
Rotavirus
Short chain galacto‐oligosaccharides (scGOS)
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spelling Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early LifeSáez Fuertes, LauraRio Aige, KarlaMassot-Cladera, MalénCastell, MargaridaKnipping, KarenGarssen, JohanBourdet-Sicard, RaphaëlleRodríguez-Lagunas, María JoséCollado, María CarmenPérez-Cano, Francisco JoséBifidobacterium breve M‐16VInfancyLong chain fructo‐oligosaccharides (lcFOS)RotavirusShort chain galacto‐oligosaccharides (scGOS)The immune system of newborns is underdeveloped, leaving them susceptible to infections like rotavirus (RV). Despite vaccines, RV remains a leading cause of child mortality, especially in developing countries. Maternal immunity is transferred during pregnancy and breastfeeding to the offspring providing protection against RV infection. This study aims to explore how the maternal diet can enhance the newborn's ability to fight early infections. Pregnant rats received orally Bifidobacterium breve M-16 V and short chain galacto-oligosaccharides (scGOS)/long chain fructo-oligosaccharides (lcFOS). At day 5 of life pups are infected with RV and at day 8, samples are collected for the infection analysis. Pups whose mothers received the synbiotic have lower RV infection severity. The levels of immunoglobulins (Ig) IgG2c and IgA are raised in pups' plasma and digested milk, respectively. Synbiotic supplementation improves intestinal maturation and increases gene expression of immune-related genes. In conclusion, the administration of this synbiotic to gestating and lactating mothers ameliorates the incidence and severity of the pup's diarrhea caused by the RV infection by improving their immunity.The research described in this paper was supported by LaMarató-TV3 (DIM-2-ELI, ref. 2018–27/30-31). The authors would like to express their gratitude to Paula Cabré for her assistance. The authors are grateful to Danone Research & Innovation for providing the synbiotic mix. INSA-UB is a Maria de Maeztu Unit of Excellence (Grant CEX2021-001234-M) and IATA-CSIC a Severo Ochoa Excellence Center (Grant CEX2021-001189-S) funded by MICIN/AEI/FEDER, UE.Peer reviewedJohn Wiley & SonsFundació La Marató de TV3Agencia Estatal de Investigación (España)Massot-Cladera, Malén [0000-0002-5220-2793]Rodríguez-Lagunas, María José [0000-0001-7870-8250]Collado, María Carmen [0000-0002-6204-4864]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/373845https://api.elsevier.com/content/abstract/scopus_id/85207343636reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésMolecular nutrition & food researchhttps://doi.org/10.1002/mnfr.202400377Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3738452026-05-22T06:33:51Z
dc.title.none.fl_str_mv Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
title Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
spellingShingle Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
Sáez Fuertes, Laura
Bifidobacterium breve M‐16V
Infancy
Long chain fructo‐oligosaccharides (lcFOS)
Rotavirus
Short chain galacto‐oligosaccharides (scGOS)
title_short Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
title_full Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
title_fullStr Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
title_full_unstemmed Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
title_sort Bifidobacterium breve M-16 V and scGOS/lcFOS Supplementation to Dams Ameliorates Infant Rotavirus Infection in Early Life
dc.creator.none.fl_str_mv Sáez Fuertes, Laura
Rio Aige, Karla
Massot-Cladera, Malén
Castell, Margarida
Knipping, Karen
Garssen, Johan
Bourdet-Sicard, Raphaëlle
Rodríguez-Lagunas, María José
Collado, María Carmen
Pérez-Cano, Francisco José
author Sáez Fuertes, Laura
author_facet Sáez Fuertes, Laura
Rio Aige, Karla
Massot-Cladera, Malén
Castell, Margarida
Knipping, Karen
Garssen, Johan
Bourdet-Sicard, Raphaëlle
Rodríguez-Lagunas, María José
Collado, María Carmen
Pérez-Cano, Francisco José
author_role author
author2 Rio Aige, Karla
Massot-Cladera, Malén
Castell, Margarida
Knipping, Karen
Garssen, Johan
Bourdet-Sicard, Raphaëlle
Rodríguez-Lagunas, María José
Collado, María Carmen
Pérez-Cano, Francisco José
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fundació La Marató de TV3
Agencia Estatal de Investigación (España)
Massot-Cladera, Malén [0000-0002-5220-2793]
Rodríguez-Lagunas, María José [0000-0001-7870-8250]
Collado, María Carmen [0000-0002-6204-4864]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Bifidobacterium breve M‐16V
Infancy
Long chain fructo‐oligosaccharides (lcFOS)
Rotavirus
Short chain galacto‐oligosaccharides (scGOS)
topic Bifidobacterium breve M‐16V
Infancy
Long chain fructo‐oligosaccharides (lcFOS)
Rotavirus
Short chain galacto‐oligosaccharides (scGOS)
description The immune system of newborns is underdeveloped, leaving them susceptible to infections like rotavirus (RV). Despite vaccines, RV remains a leading cause of child mortality, especially in developing countries. Maternal immunity is transferred during pregnancy and breastfeeding to the offspring providing protection against RV infection. This study aims to explore how the maternal diet can enhance the newborn's ability to fight early infections. Pregnant rats received orally Bifidobacterium breve M-16 V and short chain galacto-oligosaccharides (scGOS)/long chain fructo-oligosaccharides (lcFOS). At day 5 of life pups are infected with RV and at day 8, samples are collected for the infection analysis. Pups whose mothers received the synbiotic have lower RV infection severity. The levels of immunoglobulins (Ig) IgG2c and IgA are raised in pups' plasma and digested milk, respectively. Synbiotic supplementation improves intestinal maturation and increases gene expression of immune-related genes. In conclusion, the administration of this synbiotic to gestating and lactating mothers ameliorates the incidence and severity of the pup's diarrhea caused by the RV infection by improving their immunity.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/373845
https://api.elsevier.com/content/abstract/scopus_id/85207343636
url http://hdl.handle.net/10261/373845
https://api.elsevier.com/content/abstract/scopus_id/85207343636
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Molecular nutrition & food research
https://doi.org/10.1002/mnfr.202400377
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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