Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients

Acute pancreatitis; Comorbidity; Hospital mortality

Detalles Bibliográficos
Autores: Hidalgo Rivera, Nils Jimmy, Pando Rau, Elizabeth, Fernandes Montes, Nair Sonia, Barros Segura, Marta, Herms Perez, Daniel, Balsells Valls, Joaquin, Charco Torra, Ramon, Mata Mata, Rodrigo José, Villasante, Sara, Blanco Cuso, Laia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/9262
Acceso en línea:https://hdl.handle.net/11351/9262
http://hdl.handle.net/11351/9262
Access Level:acceso abierto
Palabra clave:Pancreatitis - Mortalitat
Comorbiditat
DISEASES::Digestive System Diseases::Pancreatic Diseases::Pancreatitis
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
PUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Health-Disease Process::Comorbidity
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades pancreáticas::pancreatitis
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
SALUD PÚBLICA::epidemiología y bioestadística::epidemiología::proceso salud-enfermedad::comorbilidad
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oai_identifier_str oai:recercat.cat:11351/9262
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients
title Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients
spellingShingle Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients
Hidalgo Rivera, Nils Jimmy
Pancreatitis - Mortalitat
Comorbiditat
DISEASES::Digestive System Diseases::Pancreatic Diseases::Pancreatitis
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
PUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Health-Disease Process::Comorbidity
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades pancreáticas::pancreatitis
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
SALUD PÚBLICA::epidemiología y bioestadística::epidemiología::proceso salud-enfermedad::comorbilidad
title_short Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients
title_full Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients
title_fullStr Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients
title_full_unstemmed Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients
title_sort Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients
dc.creator.none.fl_str_mv Hidalgo Rivera, Nils Jimmy
Pando Rau, Elizabeth
Fernandes Montes, Nair Sonia
Barros Segura, Marta
Herms Perez, Daniel
Balsells Valls, Joaquin
Charco Torra, Ramon
Mata Mata, Rodrigo José
Villasante, Sara
Blanco Cuso, Laia
author Hidalgo Rivera, Nils Jimmy
author_facet Hidalgo Rivera, Nils Jimmy
Pando Rau, Elizabeth
Fernandes Montes, Nair Sonia
Barros Segura, Marta
Herms Perez, Daniel
Balsells Valls, Joaquin
Charco Torra, Ramon
Mata Mata, Rodrigo José
Villasante, Sara
Blanco Cuso, Laia
author_role author
author2 Pando Rau, Elizabeth
Fernandes Montes, Nair Sonia
Barros Segura, Marta
Herms Perez, Daniel
Balsells Valls, Joaquin
Charco Torra, Ramon
Mata Mata, Rodrigo José
Villasante, Sara
Blanco Cuso, Laia
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Hidalgo NJ, Pando E] Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Cirurgia Hepatobiliopancreàtica i Trasplantaments, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Mata R, Fernandes N, Villasante S, Barros M, Herms D, Blanco L, Balsells J, Charco R] Servei de Cirurgia Hepatobiliopancreàtica i Trasplantaments, Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Pancreatitis - Mortalitat
Comorbiditat
DISEASES::Digestive System Diseases::Pancreatic Diseases::Pancreatitis
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
PUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Health-Disease Process::Comorbidity
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades pancreáticas::pancreatitis
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
SALUD PÚBLICA::epidemiología y bioestadística::epidemiología::proceso salud-enfermedad::comorbilidad
topic Pancreatitis - Mortalitat
Comorbiditat
DISEASES::Digestive System Diseases::Pancreatic Diseases::Pancreatitis
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
PUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Health-Disease Process::Comorbidity
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades pancreáticas::pancreatitis
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
SALUD PÚBLICA::epidemiología y bioestadística::epidemiología::proceso salud-enfermedad::comorbilidad
description Acute pancreatitis; Comorbidity; Hospital mortality
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/9262
http://hdl.handle.net/11351/9262
url https://hdl.handle.net/11351/9262
http://hdl.handle.net/11351/9262
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv BMC Gastroenterology;23
https://doi.org/10.1186/s12876-023-02730-6
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407083019894784
spelling Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patientsHidalgo Rivera, Nils JimmyPando Rau, ElizabethFernandes Montes, Nair SoniaBarros Segura, MartaHerms Perez, DanielBalsells Valls, JoaquinCharco Torra, RamonMata Mata, Rodrigo JoséVillasante, SaraBlanco Cuso, LaiaPancreatitis - MortalitatComorbiditatDISEASES::Digestive System Diseases::Pancreatic Diseases::PancreatitisOther subheadings::Other subheadings::Other subheadings::Other subheadings::/mortalityPUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Health-Disease Process::ComorbidityENFERMEDADES::enfermedades del sistema digestivo::enfermedades pancreáticas::pancreatitisOtros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidadSALUD PÚBLICA::epidemiología y bioestadística::epidemiología::proceso salud-enfermedad::comorbilidadAcute pancreatitis; Comorbidity; Hospital mortalityPancreatitis aguda; Comorbilidad; Mortalidad hospitalariaPancreatitis aguda; Comorbilitat; Mortalitat hospitalàriaBackground The impact of pre-existing comorbidities on acute pancreatitis (AP) mortality is not clearly defined. Our study aims to determine the trend in AP hospital mortality and the role of comorbidities as a predictor of hospital mortality. Methods We analyzed patients aged ≥ 18 years hospitalized with AP diagnosis between 2016 and 2019. The data have been extracted from the Spanish National Hospital Discharge Database of the Spanish Ministry of Health. We performed a univariate and multivariable analysis of the association of age, sex, and comorbidities with hospital mortality in patients with AP. The role of the Charlson and Elixhauser comorbidity indices as predictors of mortality was evaluated. Results A total of 110,021 patients diagnosed with AP were hospitalized during the analyzed period. Hospital mortality was 3.8%, with a progressive decrease observed in the years evaluated. In multivariable analysis, age ≥ 65 years (OR: 4.11, p < 0.001), heart disease (OR: 1.73, p < 0.001), renal disease (OR: 1.99, p < 0.001), moderate-severe liver disease (OR: 2.86, p < 0.001), peripheral vascular disease (OR: 1.43, p < 0.001), and cerebrovascular disease (OR: 1.63, p < 0.001) were independent risk factors for mortality. The Charlson > 1.5 (OR: 2.03, p < 0.001) and Elixhauser > 1.5 (OR: 2.71, p < 0.001) comorbidity indices were also independently associated with mortality, and ROC curve analysis showed that they are useful for predicting hospital mortality. Conclusions Advanced age, heart disease, renal disease, moderate-severe liver disease, peripheral vascular disease, and cerebrovascular disease before admission were independently associated with hospital mortality. The Charlson and Elixhauser comorbidity indices are useful for predicting hospital mortality in AP patients. Peer Review reports Background Acute pancreatitis (AP) is a prevalent acute inflammatory disease that affects the pancreas, with an increased incidence in recent years [1, 2]. Most cases are mild with a self-limited course [3]. However, patients with severe acute pancreatitis have a high mortality rate (20–50%) [4,5,6]. For this reason, many efforts have been made to find predictors of severity and mortality in patients with AP [7,8,9,10,11] to identify patients who need admission to an intensive care unit or specific treatment. In clinical practice, systems such as the Ranson score, the Acute Physiology and Chronic Health Evaluation II (APACHE II) score, the Computed Tomography Severity Index (CTSI), the Bedside Index for Severity in Acute Pancreatitis (BISAP), and various biochemical markers are used to predict severe AP and mortality [3, 12,13,14,15,16]. However, hospital mortality in AP could also be related to intrinsic patient characteristics, such as individual comorbidities. Most classic scores do not consider comorbidities before admission, except for APACHE II, but are restricted to severe chronic diseases. According to some previous studies, patients with certain comorbidities, such as obesity [17], hypertriglyceridemia [18], chronic renal failure [19], diabetes [20, 21], and systemic lupus erythematosus [22], are associated with a higher risk of AP severity and mortality. However, few studies currently evaluate the impact of comorbidities on AP severity and mortality. Our study aimed to determine the relevance of comorbidities and their indexes (Charlson and Elixhauser) as predictors of hospital mortality in patients with AP.BMCInstitut Català de la Salut[Hidalgo NJ, Pando E] Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Cirurgia Hepatobiliopancreàtica i Trasplantaments, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Mata R, Fernandes N, Villasante S, Barros M, Herms D, Blanco L, Balsells J, Charco R] Servei de Cirurgia Hepatobiliopancreàtica i Trasplantaments, Vall d’Hebron Hospital Universitari, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11351/9262http://hdl.handle.net/11351/9262Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésBMC Gastroenterology;23https://doi.org/10.1186/s12876-023-02730-6Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/92622026-05-29T05:05:01Z
score 15,811543

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