Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment

Background: The aim of the study was to determine the most common pharmacological strategies used in the management of major depressive disorder (MDD) after an inadequate response to first-line antidepressant treatment in clinical practice. Methods: Multicenter, non-interventional study in adult out...

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Detalles Bibliográficos
Autores: Garcia Toro, Mauro, Medina, Esteban, Galan, Jaime L., Gonzalez, Miguel A., Maurino, Jorge
Tipo de recurso: artículo
Fecha de publicación:2012
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/16605
Acceso en línea:https://hdl.handle.net/20.500.13003/16605
Access Level:acceso abierto
Palabra clave:Middle Aged
Disease Management
Female
Adult
Psychiatric Status Rating Scales
Depressive Disorder, Major
Male
Drug Synergism
Treatment Outcome
Humans
Drug Therapy, Combination
Antidepressive Agents
Resultado del Tratamiento
Masculino
Sinergismo Farmacológico
Persona de Mediana Edad
Humanos
Trastorno Depresivo Mayor
Escalas de Valoración Psiquiátrica
Quimioterapia Combinada
Antidepresivos
Manejo de la Enfermedad
Adulto
Femenino
Major depressive disorder
Response
Antidepressant treatment
Augmentation
Switching
Combination
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spelling Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatmentGarcia Toro, MauroMedina, EstebanGalan, Jaime L.Gonzalez, Miguel A.Maurino, JorgeMiddle AgedDisease ManagementFemaleAdultPsychiatric Status Rating ScalesDepressive Disorder, MajorMaleDrug SynergismTreatment OutcomeHumansDrug Therapy, CombinationAntidepressive AgentsResultado del TratamientoMasculinoSinergismo FarmacológicoPersona de Mediana EdadHumanosTrastorno Depresivo MayorEscalas de Valoración PsiquiátricaQuimioterapia CombinadaAntidepresivosManejo de la EnfermedadAdultoFemeninoMajor depressive disorderResponseAntidepressant treatmentAugmentationSwitchingCombinationBackground: The aim of the study was to determine the most common pharmacological strategies used in the management of major depressive disorder (MDD) after an inadequate response to first-line antidepressant treatment in clinical practice. Methods: Multicenter, non-interventional study in adult outpatients with a DSM-IV-TR diagnosis of MDD and inadequate response to first-line antidepressant medication. Multiple logistic regression analyses were performed to identify independent factors associated with the adoption of a specific second-line strategy. Results: A total of 273 patients were analyzed (mean age: 46.8 years, 67.8% female). Baseline mean Montgomery-Asberg Depression Rating Scale total score was 32.1 (95% CI 31.2-32.9). The most common strategies were: switching antidepressant medication (39.6%), augmentation (18.8%), and combination therapy (17.9%). Atypical antipsychotic drugs were the most commonly used agent for augmenting antidepressant effect. The presence of psychotic symptoms and the number of previous major depressive episodes were associated with the adoption of augmenting strategy (OR = 3.2 and 1.2, respectively). Conclusion: The switch to another antidepressant agent was the most common second-line therapeutic approach. Psychiatrists chose augmentation based on a worse patients' clinical profile (number of previous episodes and presence of psychotic symptoms).BMC20122012-09-1820122012-09-18research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/16605reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 2.0 Generichttps://creativecommons.org/licenses/by/2.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/166052026-06-22T12:44:07Z
dc.title.none.fl_str_mv Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment
title Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment
spellingShingle Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment
Garcia Toro, Mauro
Middle Aged
Disease Management
Female
Adult
Psychiatric Status Rating Scales
Depressive Disorder, Major
Male
Drug Synergism
Treatment Outcome
Humans
Drug Therapy, Combination
Antidepressive Agents
Resultado del Tratamiento
Masculino
Sinergismo Farmacológico
Persona de Mediana Edad
Humanos
Trastorno Depresivo Mayor
Escalas de Valoración Psiquiátrica
Quimioterapia Combinada
Antidepresivos
Manejo de la Enfermedad
Adulto
Femenino
Major depressive disorder
Response
Antidepressant treatment
Augmentation
Switching
Combination
title_short Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment
title_full Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment
title_fullStr Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment
title_full_unstemmed Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment
title_sort Treatment patterns in major depressive disorder after an inadequate response to first-line antidepressant treatment
dc.creator.none.fl_str_mv Garcia Toro, Mauro
Medina, Esteban
Galan, Jaime L.
Gonzalez, Miguel A.
Maurino, Jorge
author Garcia Toro, Mauro
author_facet Garcia Toro, Mauro
Medina, Esteban
Galan, Jaime L.
Gonzalez, Miguel A.
Maurino, Jorge
author_role author
author2 Medina, Esteban
Galan, Jaime L.
Gonzalez, Miguel A.
Maurino, Jorge
author2_role author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Middle Aged
Disease Management
Female
Adult
Psychiatric Status Rating Scales
Depressive Disorder, Major
Male
Drug Synergism
Treatment Outcome
Humans
Drug Therapy, Combination
Antidepressive Agents
Resultado del Tratamiento
Masculino
Sinergismo Farmacológico
Persona de Mediana Edad
Humanos
Trastorno Depresivo Mayor
Escalas de Valoración Psiquiátrica
Quimioterapia Combinada
Antidepresivos
Manejo de la Enfermedad
Adulto
Femenino
Major depressive disorder
Response
Antidepressant treatment
Augmentation
Switching
Combination
topic Middle Aged
Disease Management
Female
Adult
Psychiatric Status Rating Scales
Depressive Disorder, Major
Male
Drug Synergism
Treatment Outcome
Humans
Drug Therapy, Combination
Antidepressive Agents
Resultado del Tratamiento
Masculino
Sinergismo Farmacológico
Persona de Mediana Edad
Humanos
Trastorno Depresivo Mayor
Escalas de Valoración Psiquiátrica
Quimioterapia Combinada
Antidepresivos
Manejo de la Enfermedad
Adulto
Femenino
Major depressive disorder
Response
Antidepressant treatment
Augmentation
Switching
Combination
description Background: The aim of the study was to determine the most common pharmacological strategies used in the management of major depressive disorder (MDD) after an inadequate response to first-line antidepressant treatment in clinical practice. Methods: Multicenter, non-interventional study in adult outpatients with a DSM-IV-TR diagnosis of MDD and inadequate response to first-line antidepressant medication. Multiple logistic regression analyses were performed to identify independent factors associated with the adoption of a specific second-line strategy. Results: A total of 273 patients were analyzed (mean age: 46.8 years, 67.8% female). Baseline mean Montgomery-Asberg Depression Rating Scale total score was 32.1 (95% CI 31.2-32.9). The most common strategies were: switching antidepressant medication (39.6%), augmentation (18.8%), and combination therapy (17.9%). Atypical antipsychotic drugs were the most commonly used agent for augmenting antidepressant effect. The presence of psychotic symptoms and the number of previous major depressive episodes were associated with the adoption of augmenting strategy (OR = 3.2 and 1.2, respectively). Conclusion: The switch to another antidepressant agent was the most common second-line therapeutic approach. Psychiatrists chose augmentation based on a worse patients' clinical profile (number of previous episodes and presence of psychotic symptoms).
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-09-18
2012
2012-09-18
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/16605
url https://hdl.handle.net/20.500.13003/16605
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 2.0 Generic
https://creativecommons.org/licenses/by/2.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 2.0 Generic
https://creativecommons.org/licenses/by/2.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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