Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences

BACKGROUND: Numerous studies show the existence of a high prevalence of cannabis use among patients with psychosis. However, the differences between men and women who debut with a first episode of psychosis (FEP) regarding cannabis use have not been largely explored. The aim of this study was to ide...

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Autores: Setien Suero, Esther, Neergaard, Karl, Ramirez Bonilla, Mariluz, Correa Ghisays, Patricia, Fañanás Saura, Lourdes, Crepo Facorro, Benedicto, Ayesa Arriola, Rosa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/130958
Acceso en línea:https://hdl.handle.net/2445/130958
Access Level:acceso abierto
Palabra clave:Cànnabis
Psicosi
Factors sexuals en les malalties
Cannabis
Psychoses
Sex factors in disease
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spelling Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differencesSetien Suero, EstherNeergaard, KarlRamirez Bonilla, MariluzCorrea Ghisays, PatriciaFañanás Saura, LourdesCrepo Facorro, BenedictoAyesa Arriola, RosaCànnabisPsicosiFactors sexuals en les malaltiesCannabisPsychosesSex factors in diseaseBACKGROUND: Numerous studies show the existence of a high prevalence of cannabis use among patients with psychosis. However, the differences between men and women who debut with a first episode of psychosis (FEP) regarding cannabis use have not been largely explored. The aim of this study was to identify the specific sex factors and differences in clinical evolution associated with cannabis use. METHOD: Sociodemographic characteristics at baseline were considered in our sample of FEP patients to find differences depending on sex and the use of cannabis. Clinical, functional and neurocognitive variables at baseline, 1-year, and 3-years follow-up were also explored. RESULTS: A total of 549 patients, of whom 43% (N = 236) were cannabis users, 79% (N = 186) male and 21% (N = 50) female, were included in the study. There was a clear relationship between being male and being a user of cannabis (OR = 5.6). Cannabis users were younger at illness onset. Longitudinal analysis showed that women significantly improved in all three dimensions of psychotic symptoms, both in the subgroup of cannabis users and in the non-users subgroup. Conversely, subgroups of men did not show improvement in the negative dimension. In cognitive function, only men presented a significant time by group interaction in processing speed, showing a greater improvement in the subgroup of cannabis users. CONCLUSION: Despite knowing that there is a relationship between cannabis use and psychosis, due to the high prevalence of cannabis use among male FEP patients, the results showed that there were very few differences in clinical and neurocognitive outcomes between men and women who used cannabis at the start of treatment compared to those who did not.Public Library of Science (PLoS)2019201920172019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion17 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/130958Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0183613PLoS One, 2017, vol. 12, num. 8, p. e0183613https://doi.org/10.1371/journal.pone.0183613cc-by (c) Setien Suero, Esther et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1309582026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences
title Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences
spellingShingle Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences
Setien Suero, Esther
Cànnabis
Psicosi
Factors sexuals en les malalties
Cannabis
Psychoses
Sex factors in disease
title_short Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences
title_full Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences
title_fullStr Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences
title_full_unstemmed Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences
title_sort Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences
dc.creator.none.fl_str_mv Setien Suero, Esther
Neergaard, Karl
Ramirez Bonilla, Mariluz
Correa Ghisays, Patricia
Fañanás Saura, Lourdes
Crepo Facorro, Benedicto
Ayesa Arriola, Rosa
author Setien Suero, Esther
author_facet Setien Suero, Esther
Neergaard, Karl
Ramirez Bonilla, Mariluz
Correa Ghisays, Patricia
Fañanás Saura, Lourdes
Crepo Facorro, Benedicto
Ayesa Arriola, Rosa
author_role author
author2 Neergaard, Karl
Ramirez Bonilla, Mariluz
Correa Ghisays, Patricia
Fañanás Saura, Lourdes
Crepo Facorro, Benedicto
Ayesa Arriola, Rosa
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Cànnabis
Psicosi
Factors sexuals en les malalties
Cannabis
Psychoses
Sex factors in disease
topic Cànnabis
Psicosi
Factors sexuals en les malalties
Cannabis
Psychoses
Sex factors in disease
description BACKGROUND: Numerous studies show the existence of a high prevalence of cannabis use among patients with psychosis. However, the differences between men and women who debut with a first episode of psychosis (FEP) regarding cannabis use have not been largely explored. The aim of this study was to identify the specific sex factors and differences in clinical evolution associated with cannabis use. METHOD: Sociodemographic characteristics at baseline were considered in our sample of FEP patients to find differences depending on sex and the use of cannabis. Clinical, functional and neurocognitive variables at baseline, 1-year, and 3-years follow-up were also explored. RESULTS: A total of 549 patients, of whom 43% (N = 236) were cannabis users, 79% (N = 186) male and 21% (N = 50) female, were included in the study. There was a clear relationship between being male and being a user of cannabis (OR = 5.6). Cannabis users were younger at illness onset. Longitudinal analysis showed that women significantly improved in all three dimensions of psychotic symptoms, both in the subgroup of cannabis users and in the non-users subgroup. Conversely, subgroups of men did not show improvement in the negative dimension. In cognitive function, only men presented a significant time by group interaction in processing speed, showing a greater improvement in the subgroup of cannabis users. CONCLUSION: Despite knowing that there is a relationship between cannabis use and psychosis, due to the high prevalence of cannabis use among male FEP patients, the results showed that there were very few differences in clinical and neurocognitive outcomes between men and women who used cannabis at the start of treatment compared to those who did not.
publishDate 2017
dc.date.none.fl_str_mv 2017
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/130958
url https://hdl.handle.net/2445/130958
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0183613
PLoS One, 2017, vol. 12, num. 8, p. e0183613
https://doi.org/10.1371/journal.pone.0183613
dc.rights.none.fl_str_mv cc-by (c) Setien Suero, Esther et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Setien Suero, Esther et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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