An Innovative Stereolithography 3D Tubular Method for Ultrathin Polymeric Stent Manufacture: The Effect of Process Parameters

In the last decades, researchers have been developing bioresorbable stents (BRS) to overcome the long-term complications of drug-eluting stents (DES). However, BRS technology still presents challenging limitations in terms of manufacturing, materials, or mechanical properties. At this juncture, comp...

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Detalles Bibliográficos
Autores: Bosch Collell, Aniol, Casanova Batlle, Enric, Constantin, Iuliana, Rubio, Carles, Ciurana, Quim de, Guerra Sánchez, Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/23731
Acceso en línea:http://hdl.handle.net/10256/23731
Access Level:acceso abierto
Palabra clave:Pròtesis de Stent -- Fabricació
Stents (Surgery) -- Construction
Polímers en medicina
Polymers in medicine
Impressió 3D
Three-dimensional printing
Fabricació additiva
Additive manufacturing
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spelling An Innovative Stereolithography 3D Tubular Method for Ultrathin Polymeric Stent Manufacture: The Effect of Process ParametersBosch Collell, AniolCasanova Batlle, EnricConstantin, IulianaRubio, CarlesCiurana, Quim deGuerra Sánchez, AntonioPròtesis de Stent -- FabricacióStents (Surgery) -- ConstructionPolímers en medicinaPolymers in medicineImpressió 3DThree-dimensional printingFabricació additivaAdditive manufacturingIn the last decades, researchers have been developing bioresorbable stents (BRS) to overcome the long-term complications of drug-eluting stents (DES). However, BRS technology still presents challenging limitations in terms of manufacturing, materials, or mechanical properties. At this juncture, companies have developed ultrathin DES that may further improve the efficacy and safety profile of traditional DES by reducing the risk of target-lesion and target-vessel failures until BRS are developed. Nonetheless, the metallic platform of ultrathin DES still presents problems related to their cellular response. The use of polymers as a permanent platform in DES has not previously been studied due to the limitations of current manufacturing technologies. In this work, an innovative manufacturing method for polymeric stent production using tubular stereolithography (SLA) technology is proposed both for BRS and for ultrathin polymeric DES. The effects of manufacturing process parameters were studied by modelling the outcomes (stent thickness and strut width) with the key manufacturing variables (exposure, resin volume, and number of layers). Two different laser setups were used to compare the results. Microscopy results proved the merit of this novel tubular SLA process, which was able to obtain stents with 70 μm strut width and thickness in barely 4 min using only 0.2 mL of resin. Differential Scanning Calorimetry (DSC) results showed the stability of the manufacturing method. The results obtained with this innovative technology are promising and overcome the limitations of other previously used and available technologiesThis work was financially supported by the Catalan Government through the funding grant ACCIÓ-Eurecat (Project TRAÇA2022-DESTOFU). A. Bosch is a fellow of Eurecat’s “Vicente López” PhD grant programMDPI (Multidisciplinary Digital Publishing Institute)2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/23731http://hdl.handle.net/10256/23731Polymers, 2023, vol. 15, núm. 21, p. 4298Articles publicats (D-EMCI)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.3390/polym15214298info:eu-repo/semantics/altIdentifier/eissn/2073-4360Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/237312026-05-29T05:05:01Z
dc.title.none.fl_str_mv An Innovative Stereolithography 3D Tubular Method for Ultrathin Polymeric Stent Manufacture: The Effect of Process Parameters
title An Innovative Stereolithography 3D Tubular Method for Ultrathin Polymeric Stent Manufacture: The Effect of Process Parameters
spellingShingle An Innovative Stereolithography 3D Tubular Method for Ultrathin Polymeric Stent Manufacture: The Effect of Process Parameters
Bosch Collell, Aniol
Pròtesis de Stent -- Fabricació
Stents (Surgery) -- Construction
Polímers en medicina
Polymers in medicine
Impressió 3D
Three-dimensional printing
Fabricació additiva
Additive manufacturing
title_short An Innovative Stereolithography 3D Tubular Method for Ultrathin Polymeric Stent Manufacture: The Effect of Process Parameters
title_full An Innovative Stereolithography 3D Tubular Method for Ultrathin Polymeric Stent Manufacture: The Effect of Process Parameters
title_fullStr An Innovative Stereolithography 3D Tubular Method for Ultrathin Polymeric Stent Manufacture: The Effect of Process Parameters
title_full_unstemmed An Innovative Stereolithography 3D Tubular Method for Ultrathin Polymeric Stent Manufacture: The Effect of Process Parameters
title_sort An Innovative Stereolithography 3D Tubular Method for Ultrathin Polymeric Stent Manufacture: The Effect of Process Parameters
dc.creator.none.fl_str_mv Bosch Collell, Aniol
Casanova Batlle, Enric
Constantin, Iuliana
Rubio, Carles
Ciurana, Quim de
Guerra Sánchez, Antonio
author Bosch Collell, Aniol
author_facet Bosch Collell, Aniol
Casanova Batlle, Enric
Constantin, Iuliana
Rubio, Carles
Ciurana, Quim de
Guerra Sánchez, Antonio
author_role author
author2 Casanova Batlle, Enric
Constantin, Iuliana
Rubio, Carles
Ciurana, Quim de
Guerra Sánchez, Antonio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Pròtesis de Stent -- Fabricació
Stents (Surgery) -- Construction
Polímers en medicina
Polymers in medicine
Impressió 3D
Three-dimensional printing
Fabricació additiva
Additive manufacturing
topic Pròtesis de Stent -- Fabricació
Stents (Surgery) -- Construction
Polímers en medicina
Polymers in medicine
Impressió 3D
Three-dimensional printing
Fabricació additiva
Additive manufacturing
description In the last decades, researchers have been developing bioresorbable stents (BRS) to overcome the long-term complications of drug-eluting stents (DES). However, BRS technology still presents challenging limitations in terms of manufacturing, materials, or mechanical properties. At this juncture, companies have developed ultrathin DES that may further improve the efficacy and safety profile of traditional DES by reducing the risk of target-lesion and target-vessel failures until BRS are developed. Nonetheless, the metallic platform of ultrathin DES still presents problems related to their cellular response. The use of polymers as a permanent platform in DES has not previously been studied due to the limitations of current manufacturing technologies. In this work, an innovative manufacturing method for polymeric stent production using tubular stereolithography (SLA) technology is proposed both for BRS and for ultrathin polymeric DES. The effects of manufacturing process parameters were studied by modelling the outcomes (stent thickness and strut width) with the key manufacturing variables (exposure, resin volume, and number of layers). Two different laser setups were used to compare the results. Microscopy results proved the merit of this novel tubular SLA process, which was able to obtain stents with 70 μm strut width and thickness in barely 4 min using only 0.2 mL of resin. Differential Scanning Calorimetry (DSC) results showed the stability of the manufacturing method. The results obtained with this innovative technology are promising and overcome the limitations of other previously used and available technologies
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/23731
http://hdl.handle.net/10256/23731
url http://hdl.handle.net/10256/23731
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/polym15214298
info:eu-repo/semantics/altIdentifier/eissn/2073-4360
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI (Multidisciplinary Digital Publishing Institute)
publisher.none.fl_str_mv MDPI (Multidisciplinary Digital Publishing Institute)
dc.source.none.fl_str_mv Polymers, 2023, vol. 15, núm. 21, p. 4298
Articles publicats (D-EMCI)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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