Role of VEGF Polymorphisms in the Susceptibility and Severity of Interstitial Lung Disease

The search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders. Consequently, we assessed, for the first time, the role of VEGF pol...

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Detalles Bibliográficos
Autores: Remuzgo-Martínez, Sara|||0000-0003-4455-7241, Genre, Fernanda|||0000-0003-3612-1448, Pulito-Cueto, Verónica|||0000-0002-3534-8467, Atienza-Mateo, Belén|||0000-0001-7119-0786, Mora Cuesta, Víctor Manuel|||0000-0002-8161-0462, Iturbe, David|||0000-0002-5241-266X, Fernández Rozas, Sonia María, Lera-Gómez, Leticia, Alonso Lecue, Pilar, Ussetti, María Piedad, Laporta, Rosalía, Berastegui García, Cristina|||0000-0001-9774-9349, Solé, Amparo, Pérez González, Virginia Luz, De Pablo Gafas, Alicia, Gualillo, Oreste|||0000-0002-7154-1328, Cifrián, José Manuel|||0000-0003-3682-0142, López-Mejías, Raquel|||0000-0003-0548-2689, Gonzalez-Gay, MA.|||0000-0002-7924-7406
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:255517
Acceso en línea:https://ddd.uab.cat/record/255517
https://dx.doi.org/urn:doi:10.3390/biomedicines9050458
Access Level:acceso abierto
Palabra clave:Interstitial lung disease
Idiopathic interstitial pneumonia
Vascular endothelial growth factor
Biomarker
Genetics
Descripción
Sumario:The search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders. Consequently, we assessed, for the first time, the role of VEGF polymorphisms in the susceptibility and severity of ILD. A total of 436 Caucasian ILD patients (244 with idiopathic interstitial pneumonias (IIPs) and 192 with non-IIP) and 536 ethnically-matched healthy controls were genotyped for VEGF rs833061, rs1570360, rs2010963, rs3025020, and rs3025039 polymorphisms by TaqMan assays. Pulmonary function tests were collected from all the patients. VEGF serum levels were determined by ELISA in a subgroup of patients. No VEGF genotype, allele, carrier, or haplotype differences were found between ILD patients and controls as well as between IIP and non-IIP patients. However, an association of rs1570360 with IIP in women and also with lung function in IIP patients was found. None of the VEGF polymorphisms were associated with VEGF levels. In conclusion, our results suggest that VEGF does not seem to play a relevant role in ILD, although rs1570360 may influence the severity of ILD in women and a worse outcome in IIP patients.

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