Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism

Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associ...

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Detalles Bibliográficos
Autores: Papandreou, Christopher, Li, Jun, Liang, Liming, Bulló, Mònica, Zheng, Yan, Ruiz-Canela, Miguel, Yu, Edward, Guasch Ferré, Marta, Razquin, Cristina, Clish, Clary B., Corella, Dolores, Estruch, Ramón, Ros, Emilio, Fitó Colomer, Montserrat, Arós, Fernando, Serra-Majem, Luis, Rosique-Esteban, Nuria, Martínez-González, Miguel Ángel, 1957-, Hu, Frank B., Salas-Salvadó, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/44303
Acceso en línea:http://hdl.handle.net/10230/44303
http://dx.doi.org/10.1038/s41598-019-39441-6
Access Level:acceso abierto
Palabra clave:Metabòlits
Diabetis
Descripción
Sumario:Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associations. This is a case-cohort design study within the PREDIMED study, with 251 incident T2D cases and a random sample of 694 participants (641 non-cases and 53 overlapping cases) without T2D at baseline (median follow-up: 3.8 years). Metabolites were semi-quantitatively profiled with LC-MS/MS. Cox regression analysis revealed that high plasma allantoin levels, including allantoin-to-uric acid ratio and high xanthine-to-hypoxanthine ratio were inversely and positively associated with T2D risk, respectively, independently of classical risk factors. Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. The potential mechanisms linking the aforementioned purine metabolites and T2D risk must be also further investigated.

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