Evidence from transgenic mice that interferon-β may be involved in the onset of diabetes mellitus
A number of cytokines have been shown to alter the function of pancreatic β-cells and thus might be involved in the development of type 1 diabetes. Interferon-β (IFN-β) expression is induced in epithelial cells by several viruses, and it has been detected in islets of type 1 diabetic patients. Here...
| Autores: | , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 1998 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:306553 |
| Acesso em linha: | https://ddd.uab.cat/record/306553 https://dx.doi.org/urn:doi:10.1074/jbc.273.20.12332 |
| Access Level: | acceso abierto |
| Palavra-chave: | SDG 3 - Good Health and Well-being |
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Evidence from transgenic mice that interferon-β may be involved in the onset of diabetes mellitusPelegrin, Mireia|||0000-0002-0117-2010Devedjian, Jean ChristopheCosta Farré, Cristina|||0000-0002-0224-6747Visa, JoanaSolanes, GemmaPujol i Altarriba, Anna|||0000-0002-3484-598XAsins, GuillerminaValera, AlfonsBosch i Tubert, Fàtima|||0000-0002-7705-5515SDG 3 - Good Health and Well-beingA number of cytokines have been shown to alter the function of pancreatic β-cells and thus might be involved in the development of type 1 diabetes. Interferon-β (IFN-β) expression is induced in epithelial cells by several viruses, and it has been detected in islets of type 1 diabetic patients. Here we show that treatment of isolated mouse islets with this cytokine was able to alter insulin secretion in vitro. To study whether IFN- β alters β-cell function in vivo and leads to diabetes, we have developed transgenic mice (C57BL6/SJL) expressing IFN-β in β-cells. These mice showed functional alterations in islets and impaired glucose-stimulated insulin secretion. Transgenic animals presented mild hyperglycemia, hypoinsulinemia, hypertriglyceridemia, and altered glucose tolerance test, all features of a prediabetic state. However, they developed overt diabetes, with lymphocytic infiltration of the islets, when treated with low doses of streptozotocin, which did not induce diabetes in control mice. In addition, about 9% of the transgenic mice obtained from the N3 back-cross to outbred albino CD-1 mice spontaneously developed severe hyperglycemia and hypoinsulinemia and showed mononuclear infiltration of the islets. These results suggest that IFN-β may be involved in the onset of type 1 diabetes when combined with either an additional factor or a susceptible genetic background. 11998-01-0119981998-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/306553https://dx.doi.org/urn:doi:10.1074/jbc.273.20.12332reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3065532026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Evidence from transgenic mice that interferon-β may be involved in the onset of diabetes mellitus |
| title |
Evidence from transgenic mice that interferon-β may be involved in the onset of diabetes mellitus |
| spellingShingle |
Evidence from transgenic mice that interferon-β may be involved in the onset of diabetes mellitus Pelegrin, Mireia|||0000-0002-0117-2010 SDG 3 - Good Health and Well-being |
| title_short |
Evidence from transgenic mice that interferon-β may be involved in the onset of diabetes mellitus |
| title_full |
Evidence from transgenic mice that interferon-β may be involved in the onset of diabetes mellitus |
| title_fullStr |
Evidence from transgenic mice that interferon-β may be involved in the onset of diabetes mellitus |
| title_full_unstemmed |
Evidence from transgenic mice that interferon-β may be involved in the onset of diabetes mellitus |
| title_sort |
Evidence from transgenic mice that interferon-β may be involved in the onset of diabetes mellitus |
| dc.creator.none.fl_str_mv |
Pelegrin, Mireia|||0000-0002-0117-2010 Devedjian, Jean Christophe Costa Farré, Cristina|||0000-0002-0224-6747 Visa, Joana Solanes, Gemma Pujol i Altarriba, Anna|||0000-0002-3484-598X Asins, Guillermina Valera, Alfons Bosch i Tubert, Fàtima|||0000-0002-7705-5515 |
| author |
Pelegrin, Mireia|||0000-0002-0117-2010 |
| author_facet |
Pelegrin, Mireia|||0000-0002-0117-2010 Devedjian, Jean Christophe Costa Farré, Cristina|||0000-0002-0224-6747 Visa, Joana Solanes, Gemma Pujol i Altarriba, Anna|||0000-0002-3484-598X Asins, Guillermina Valera, Alfons Bosch i Tubert, Fàtima|||0000-0002-7705-5515 |
| author_role |
author |
| author2 |
Devedjian, Jean Christophe Costa Farré, Cristina|||0000-0002-0224-6747 Visa, Joana Solanes, Gemma Pujol i Altarriba, Anna|||0000-0002-3484-598X Asins, Guillermina Valera, Alfons Bosch i Tubert, Fàtima|||0000-0002-7705-5515 |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
SDG 3 - Good Health and Well-being |
| topic |
SDG 3 - Good Health and Well-being |
| description |
A number of cytokines have been shown to alter the function of pancreatic β-cells and thus might be involved in the development of type 1 diabetes. Interferon-β (IFN-β) expression is induced in epithelial cells by several viruses, and it has been detected in islets of type 1 diabetic patients. Here we show that treatment of isolated mouse islets with this cytokine was able to alter insulin secretion in vitro. To study whether IFN- β alters β-cell function in vivo and leads to diabetes, we have developed transgenic mice (C57BL6/SJL) expressing IFN-β in β-cells. These mice showed functional alterations in islets and impaired glucose-stimulated insulin secretion. Transgenic animals presented mild hyperglycemia, hypoinsulinemia, hypertriglyceridemia, and altered glucose tolerance test, all features of a prediabetic state. However, they developed overt diabetes, with lymphocytic infiltration of the islets, when treated with low doses of streptozotocin, which did not induce diabetes in control mice. In addition, about 9% of the transgenic mice obtained from the N3 back-cross to outbred albino CD-1 mice spontaneously developed severe hyperglycemia and hypoinsulinemia and showed mononuclear infiltration of the islets. These results suggest that IFN-β may be involved in the onset of type 1 diabetes when combined with either an additional factor or a susceptible genetic background. |
| publishDate |
1998 |
| dc.date.none.fl_str_mv |
1 1998-01-01 1998 1998-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/306553 https://dx.doi.org/urn:doi:10.1074/jbc.273.20.12332 |
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https://ddd.uab.cat/record/306553 https://dx.doi.org/urn:doi:10.1074/jbc.273.20.12332 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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