Neurokinin-1 receptor antagonists against hepatoblastoma

This article belongs to the Special Issue Hepatoblastoma and Pediatric Liver Tumors.

Detalles Bibliográficos
Autores: Muñoz Sáez, Miguel, Rosso González, María Luisa, Coveñas, Rafael
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/212653
Acceso en línea:http://hdl.handle.net/10261/212653
Access Level:acceso abierto
Palabra clave:NK-1 receptor
Substance P
Hepatoblastoma
Aprepitant
Antitumor
Apoptosis
Angiogenesis
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spelling Neurokinin-1 receptor antagonists against hepatoblastomaMuñoz Sáez, MiguelRosso González, María LuisaCoveñas, RafaelNK-1 receptorSubstance PHepatoblastomaAprepitantAntitumorApoptosisAngiogenesisThis article belongs to the Special Issue Hepatoblastoma and Pediatric Liver Tumors.Hepatoblastoma (HB) is the most common malignant liver tumor that occurs during childhood. The prognosis of children with HB is favorable when a complete surgical resection of the tumor is possible, but for high-risk patients, the prognosis is much worse. New anti-HB strategies must be urgently developed. The undecapeptide substance P (SP) after binding to the neurokinin-1 receptor (NK-1R), regulates cancer cell proliferation, exerts an antiapoptotic effect, induces cell migration for invasion/metastasis, and triggers endothelial cell proliferation for neoangiogenesis. HB samples and cell lines overexpress NK-1R (the truncated form) and SP elicits HB cell proliferation. One of these strategies could be the use of non-peptide NK-1R antagonists. These antagonists exert, in a concentration-dependent manner, an antiproliferative action against HB cells (inhibit cell proliferation and induce the death of HB cells by apoptosis). NK-1R antagonists exerted a dual effect in HB: Decreased both tumor volume and angiogenic activity. Thus, the SP/NK-1R system is an important target in the HB treatment and NK-1R antagonists could act as specific drugs against HB cells. In this review, we update and discuss the use of NK-1R antagonists in the treatment of HB.This research was funded by “Programa XI: Financiación de Unidades de Excelencia de la Universidad de Salamanca” (Spain).Multidisciplinary Digital Publishing InstituteUniversidad de SalamancaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020192020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/212653reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/cancers11091258Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2126532026-05-22T06:33:51Z
dc.title.none.fl_str_mv Neurokinin-1 receptor antagonists against hepatoblastoma
title Neurokinin-1 receptor antagonists against hepatoblastoma
spellingShingle Neurokinin-1 receptor antagonists against hepatoblastoma
Muñoz Sáez, Miguel
NK-1 receptor
Substance P
Hepatoblastoma
Aprepitant
Antitumor
Apoptosis
Angiogenesis
title_short Neurokinin-1 receptor antagonists against hepatoblastoma
title_full Neurokinin-1 receptor antagonists against hepatoblastoma
title_fullStr Neurokinin-1 receptor antagonists against hepatoblastoma
title_full_unstemmed Neurokinin-1 receptor antagonists against hepatoblastoma
title_sort Neurokinin-1 receptor antagonists against hepatoblastoma
dc.creator.none.fl_str_mv Muñoz Sáez, Miguel
Rosso González, María Luisa
Coveñas, Rafael
author Muñoz Sáez, Miguel
author_facet Muñoz Sáez, Miguel
Rosso González, María Luisa
Coveñas, Rafael
author_role author
author2 Rosso González, María Luisa
Coveñas, Rafael
author2_role author
author
dc.contributor.none.fl_str_mv Universidad de Salamanca
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv NK-1 receptor
Substance P
Hepatoblastoma
Aprepitant
Antitumor
Apoptosis
Angiogenesis
topic NK-1 receptor
Substance P
Hepatoblastoma
Aprepitant
Antitumor
Apoptosis
Angiogenesis
description This article belongs to the Special Issue Hepatoblastoma and Pediatric Liver Tumors.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/212653
url http://hdl.handle.net/10261/212653
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/cancers11091258
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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