Cognitive impairment and resting-state network connectivity in Parkinson's disease

Previous functional MRI studies have revealed changes in the default-mode network (DMN) in Parkinson's disease (PD). The purpose of this work was to evaluate changes in the connectivity patterns of a set of cognitively relevant, dynamically interrelated brain networks in association with cognit...

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Autores: Baggio, Hugo César, Segura i Fàbregas, Bàrbara, Sala Llonch, Roser, Martí Domènech, Ma. Josep, Valldeoriola Serra, Francesc, Compta, Yaroslau, Tolosa, Eduardo, Junqué i Plaja, Carme, 1955-
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/162421
Acceso en línea:https://hdl.handle.net/2445/162421
Access Level:acceso abierto
Palabra clave:Neuropsicologia
Malaltia de Parkinson
Imatges per ressonància magnètica
Neuropsychology
Parkinson's disease
Magnetic resonance imaging
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spelling Cognitive impairment and resting-state network connectivity in Parkinson's diseaseBaggio, Hugo CésarSegura i Fàbregas, BàrbaraSala Llonch, RoserMartí Domènech, Ma. JosepValldeoriola Serra, FrancescCompta, YaroslauTolosa, EduardoJunqué i Plaja, Carme, 1955-NeuropsicologiaMalaltia de ParkinsonImatges per ressonància magnèticaNeuropsychologyParkinson's diseaseMagnetic resonance imagingPrevious functional MRI studies have revealed changes in the default-mode network (DMN) in Parkinson's disease (PD). The purpose of this work was to evaluate changes in the connectivity patterns of a set of cognitively relevant, dynamically interrelated brain networks in association with cognitive deficits in PD using resting-state functional MRI. Sixty-five non-demented PD patients and 36 matched healthy controls (HC) were included. Thirty-four percent of PD patients were classified as having mild cognitive impairment (MCI) based on performance in the three mainly-affected cognitive domains in Parkinson's disease (attention/executive, visuospatial/visuoperceptual and declarative memory). Data-driven analyses through independent-component analysis (ICA) was used to identify the DMN, the dorsal attention network (DAN) and the bilateral frontoparietal networks (FPN), which were compared between groups using a dual-regression approach. Additional seed-based analyses using a-priori defined regions of interest were used to characterize local changes in intra and inter-network connectivity. ICA results revealed reduced connectivity between the DAN and right frontoinsular cortical regions in MCI patients, which correlated with worse performance in attention/executive functions. The DMN, on the other hand, displayed increased connectivity with medial and lateral occipito-parietal regions in MCI patients; these increases correlated with worse visuospatial/visuoperceptual performance. In line with data-driven results, seed-based analyses mainly revealed reduced within-DAN, within-DMN and DAN-FPN connectivity, as well as increased DAN-DMN coupling in MCI patients. Our findings demonstrate differential connectivity changes affecting the networks evaluated, which we hypothesize to be related to the pathophysiological bases of different types of cognitive impairment in PD.Wiley2020202020152020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion37 p.application/pdfhttps://hdl.handle.net/2445/162421Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1002/hbm.22622Human Brain Mapping, 2015, vol. 36, num. 1, p. 199-212https://doi.org/10.1002/hbm.22622(c) Wiley, 2015info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1624212026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cognitive impairment and resting-state network connectivity in Parkinson's disease
title Cognitive impairment and resting-state network connectivity in Parkinson's disease
spellingShingle Cognitive impairment and resting-state network connectivity in Parkinson's disease
Baggio, Hugo César
Neuropsicologia
Malaltia de Parkinson
Imatges per ressonància magnètica
Neuropsychology
Parkinson's disease
Magnetic resonance imaging
title_short Cognitive impairment and resting-state network connectivity in Parkinson's disease
title_full Cognitive impairment and resting-state network connectivity in Parkinson's disease
title_fullStr Cognitive impairment and resting-state network connectivity in Parkinson's disease
title_full_unstemmed Cognitive impairment and resting-state network connectivity in Parkinson's disease
title_sort Cognitive impairment and resting-state network connectivity in Parkinson's disease
dc.creator.none.fl_str_mv Baggio, Hugo César
Segura i Fàbregas, Bàrbara
Sala Llonch, Roser
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Compta, Yaroslau
Tolosa, Eduardo
Junqué i Plaja, Carme, 1955-
author Baggio, Hugo César
author_facet Baggio, Hugo César
Segura i Fàbregas, Bàrbara
Sala Llonch, Roser
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Compta, Yaroslau
Tolosa, Eduardo
Junqué i Plaja, Carme, 1955-
author_role author
author2 Segura i Fàbregas, Bàrbara
Sala Llonch, Roser
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Compta, Yaroslau
Tolosa, Eduardo
Junqué i Plaja, Carme, 1955-
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neuropsicologia
Malaltia de Parkinson
Imatges per ressonància magnètica
Neuropsychology
Parkinson's disease
Magnetic resonance imaging
topic Neuropsicologia
Malaltia de Parkinson
Imatges per ressonància magnètica
Neuropsychology
Parkinson's disease
Magnetic resonance imaging
description Previous functional MRI studies have revealed changes in the default-mode network (DMN) in Parkinson's disease (PD). The purpose of this work was to evaluate changes in the connectivity patterns of a set of cognitively relevant, dynamically interrelated brain networks in association with cognitive deficits in PD using resting-state functional MRI. Sixty-five non-demented PD patients and 36 matched healthy controls (HC) were included. Thirty-four percent of PD patients were classified as having mild cognitive impairment (MCI) based on performance in the three mainly-affected cognitive domains in Parkinson's disease (attention/executive, visuospatial/visuoperceptual and declarative memory). Data-driven analyses through independent-component analysis (ICA) was used to identify the DMN, the dorsal attention network (DAN) and the bilateral frontoparietal networks (FPN), which were compared between groups using a dual-regression approach. Additional seed-based analyses using a-priori defined regions of interest were used to characterize local changes in intra and inter-network connectivity. ICA results revealed reduced connectivity between the DAN and right frontoinsular cortical regions in MCI patients, which correlated with worse performance in attention/executive functions. The DMN, on the other hand, displayed increased connectivity with medial and lateral occipito-parietal regions in MCI patients; these increases correlated with worse visuospatial/visuoperceptual performance. In line with data-driven results, seed-based analyses mainly revealed reduced within-DAN, within-DMN and DAN-FPN connectivity, as well as increased DAN-DMN coupling in MCI patients. Our findings demonstrate differential connectivity changes affecting the networks evaluated, which we hypothesize to be related to the pathophysiological bases of different types of cognitive impairment in PD.
publishDate 2015
dc.date.none.fl_str_mv 2015
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/162421
url https://hdl.handle.net/2445/162421
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1002/hbm.22622
Human Brain Mapping, 2015, vol. 36, num. 1, p. 199-212
https://doi.org/10.1002/hbm.22622
dc.rights.none.fl_str_mv (c) Wiley, 2015
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Wiley, 2015
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 37 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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