Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study

Several studies have examined environmental factors and inflammatory bowel diseases (IBD) using traditional approaches; however, provided results are still conflicting. Our aim was to determine whether lifestyle and nutrient exposures, related to IBD in observational meta-analyses, influence IBD ris...

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Autores: Carreras Torres, Robert, Ibáñez Sanz, Gemma, Obón Santacana, Mireia, Duell, Eric J., Moreno Aguado, Víctor
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/173807
Acceso en línea:https://hdl.handle.net/2445/173807
Access Level:acceso abierto
Palabra clave:Malalties inflamatòries intestinals
Epidemiologia
Inflammatory bowel diseases
Epidemiology
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spelling Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization studyCarreras Torres, RobertIbáñez Sanz, GemmaObón Santacana, MireiaDuell, Eric J.Moreno Aguado, VíctorMalalties inflamatòries intestinalsEpidemiologiaInflammatory bowel diseasesEpidemiologySeveral studies have examined environmental factors and inflammatory bowel diseases (IBD) using traditional approaches; however, provided results are still conflicting. Our aim was to determine whether lifestyle and nutrient exposures, related to IBD in observational meta-analyses, influence IBD risk using a Mendelian randomization (MR) approach. A two-sample MR approach was applied on summary-level genome-wide association results. Genetic variants strongly associated with measures of tobacco smoking, obesity and fat distribution, physical activity, and blood levels of vitamins and fatty acids were evaluated on genetic data from international IBD consortia including a total of 25,042 IBD cases (12,194 cases of Crohn's disease (CD) and 12,366 cases of ulcerative colitis (UC)) and 34,915 controls. Our results indicated that, among lifestyle exposures, being a smoker was positively associated with CD (OR 1.13, P=0.02), but it was not associated with UC risk (OR 0.99, P=0.88). Body-mass index (BMI) and body fat percentage were positively associated with CD (OR 1.11, P=0.02, per standard deviation (SD) of 4.6 kg/m(2); and OR 1.50, P=3x10(-10), per SD of 6.6%; respectively); while for UC, BMI was inversely associated (OR 0.85, P=5x10(-5); per SD) and body fat percentage showed a OR of 1.11 (P=0.11; per SD). Additionally, among nutrient exposures, omega-3 fatty acids levels were inversely associated with CD (OR 0.67, P=2x10(-6)). Our MR results did not support a protective effect for being a smoker on UC risk; however, they are compatible with a risk effect for higher body fat proportion and a protective role for higher levels of omega-3 fatty acids on CD etiology.Nature Research2021202120202021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/173807Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41598-020-76361-2Scientific Reports, 2020 vol. 10https://doi.org/10.1038/s41598-020-76361-2cc by (c) Carreras Torres et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1738072026-05-29T05:05:01Z
dc.title.none.fl_str_mv Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study
title Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study
spellingShingle Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study
Carreras Torres, Robert
Malalties inflamatòries intestinals
Epidemiologia
Inflammatory bowel diseases
Epidemiology
title_short Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study
title_full Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study
title_fullStr Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study
title_full_unstemmed Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study
title_sort Identifying environmental risk factors for inflammatory bowel diseases: a Mendelian randomization study
dc.creator.none.fl_str_mv Carreras Torres, Robert
Ibáñez Sanz, Gemma
Obón Santacana, Mireia
Duell, Eric J.
Moreno Aguado, Víctor
author Carreras Torres, Robert
author_facet Carreras Torres, Robert
Ibáñez Sanz, Gemma
Obón Santacana, Mireia
Duell, Eric J.
Moreno Aguado, Víctor
author_role author
author2 Ibáñez Sanz, Gemma
Obón Santacana, Mireia
Duell, Eric J.
Moreno Aguado, Víctor
author2_role author
author
author
author
dc.subject.none.fl_str_mv Malalties inflamatòries intestinals
Epidemiologia
Inflammatory bowel diseases
Epidemiology
topic Malalties inflamatòries intestinals
Epidemiologia
Inflammatory bowel diseases
Epidemiology
description Several studies have examined environmental factors and inflammatory bowel diseases (IBD) using traditional approaches; however, provided results are still conflicting. Our aim was to determine whether lifestyle and nutrient exposures, related to IBD in observational meta-analyses, influence IBD risk using a Mendelian randomization (MR) approach. A two-sample MR approach was applied on summary-level genome-wide association results. Genetic variants strongly associated with measures of tobacco smoking, obesity and fat distribution, physical activity, and blood levels of vitamins and fatty acids were evaluated on genetic data from international IBD consortia including a total of 25,042 IBD cases (12,194 cases of Crohn's disease (CD) and 12,366 cases of ulcerative colitis (UC)) and 34,915 controls. Our results indicated that, among lifestyle exposures, being a smoker was positively associated with CD (OR 1.13, P=0.02), but it was not associated with UC risk (OR 0.99, P=0.88). Body-mass index (BMI) and body fat percentage were positively associated with CD (OR 1.11, P=0.02, per standard deviation (SD) of 4.6 kg/m(2); and OR 1.50, P=3x10(-10), per SD of 6.6%; respectively); while for UC, BMI was inversely associated (OR 0.85, P=5x10(-5); per SD) and body fat percentage showed a OR of 1.11 (P=0.11; per SD). Additionally, among nutrient exposures, omega-3 fatty acids levels were inversely associated with CD (OR 0.67, P=2x10(-6)). Our MR results did not support a protective effect for being a smoker on UC risk; however, they are compatible with a risk effect for higher body fat proportion and a protective role for higher levels of omega-3 fatty acids on CD etiology.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/173807
url https://hdl.handle.net/2445/173807
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-020-76361-2
Scientific Reports, 2020 vol. 10
https://doi.org/10.1038/s41598-020-76361-2
dc.rights.none.fl_str_mv cc by (c) Carreras Torres et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Carreras Torres et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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