Increased CX3CL1/CX3CR1 Axis Is Related to Atherosclerosis in Subjects with Familial Combined Hyperlipidaemia, Which Is Modulated by Insulin Resistance but Not by Sex

Background: A major factor in the development of atherosclerosis is the presence of a chronic inflammatory state. The CX(3)CL1/CX(3)CR1 axis has been implicated in the development of atherosclerosis and cardiovascular disease, but until now, scarce data are available regarding the influence of the C...

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Autores: Jiménez-Martí, E, Espinosa-Bellido, C, Alabadi, B, Hurtado-Genovés, G, Enrique-Medina, A, Martín-Vañó, S, Casas, V, Nadal, EAC, Real, JT, González-Navarro, H, Martínez-Hervás, S
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p20453
Acesso em linha:https://incliva.portalinvestigacion.com/publicaciones/20453
Access Level:acceso abierto
Palavra-chave:atherosclerosis
familial combined hyperlipidaemia
insulin resistance
CX(3)CL1/CX(3)CR1 axis
inflammation
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spelling Increased CX3CL1/CX3CR1 Axis Is Related to Atherosclerosis in Subjects with Familial Combined Hyperlipidaemia, Which Is Modulated by Insulin Resistance but Not by SexJiménez-Martí, EEspinosa-Bellido, CAlabadi, BHurtado-Genovés, GEnrique-Medina, AMartín-Vañó, SCasas, VNadal, EACReal, JTGonzález-Navarro, HMartínez-Hervás, Satherosclerosisfamilial combined hyperlipidaemiainsulin resistanceCX(3)CL1/CX(3)CR1 axisinflammationBackground: A major factor in the development of atherosclerosis is the presence of a chronic inflammatory state. The CX(3)CL1/CX(3)CR1 axis has been implicated in the development of atherosclerosis and cardiovascular disease, but until now, scarce data are available regarding the influence of the CX(3)CL1/CX(3)CR1 axis in familial combined hyperlipidaemia (FCH). Since FCH is associated with a high risk of cardiovascular disease, the objective of the present study was to assess the presence of alterations in the CX(3)CL1/CX(3)CR1 axis in patients with FCH and to evaluate the influence of insulin resistance (IR) and sex. Methods: A cohort of 47 subjects with FCH and 38 control subjects was included. We measured the lipid profile, glucose, and insulin levels in plasma, circulating blood CX(3)CL1 levels, and CX(3)CR1 mRNA expression. Carotid IMT and the presence of atheroma plaques were also evaluated. Results: FCH subjects showed significantly higher activation of the CX(3)CL1/CX(3)CR1 axis than controls. In addition, FCH individuals with IR showed the worst profile of inflammation status, higher carotid IMT, and a higher prevalence of atherosclerotic plaque compared to controls and FCH patients without IR. However, sex did not influence the CX3CL1/CX3CR1 axis. Conclusions: FCH patients showed an increased CX(3)CL1/CX(3)CR1 axis, which was positively correlated with IR, but not with sex. These data could partially explain the increased risk of cardiovascular events in primary dyslipidemic patients.MDPI2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/20453BiomedicinesISSN: 22279059reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p204532026-06-07T16:35:31Z
dc.title.none.fl_str_mv Increased CX3CL1/CX3CR1 Axis Is Related to Atherosclerosis in Subjects with Familial Combined Hyperlipidaemia, Which Is Modulated by Insulin Resistance but Not by Sex
title Increased CX3CL1/CX3CR1 Axis Is Related to Atherosclerosis in Subjects with Familial Combined Hyperlipidaemia, Which Is Modulated by Insulin Resistance but Not by Sex
spellingShingle Increased CX3CL1/CX3CR1 Axis Is Related to Atherosclerosis in Subjects with Familial Combined Hyperlipidaemia, Which Is Modulated by Insulin Resistance but Not by Sex
Jiménez-Martí, E
atherosclerosis
familial combined hyperlipidaemia
insulin resistance
CX(3)CL1/CX(3)CR1 axis
inflammation
title_short Increased CX3CL1/CX3CR1 Axis Is Related to Atherosclerosis in Subjects with Familial Combined Hyperlipidaemia, Which Is Modulated by Insulin Resistance but Not by Sex
title_full Increased CX3CL1/CX3CR1 Axis Is Related to Atherosclerosis in Subjects with Familial Combined Hyperlipidaemia, Which Is Modulated by Insulin Resistance but Not by Sex
title_fullStr Increased CX3CL1/CX3CR1 Axis Is Related to Atherosclerosis in Subjects with Familial Combined Hyperlipidaemia, Which Is Modulated by Insulin Resistance but Not by Sex
title_full_unstemmed Increased CX3CL1/CX3CR1 Axis Is Related to Atherosclerosis in Subjects with Familial Combined Hyperlipidaemia, Which Is Modulated by Insulin Resistance but Not by Sex
title_sort Increased CX3CL1/CX3CR1 Axis Is Related to Atherosclerosis in Subjects with Familial Combined Hyperlipidaemia, Which Is Modulated by Insulin Resistance but Not by Sex
dc.creator.none.fl_str_mv Jiménez-Martí, E
Espinosa-Bellido, C
Alabadi, B
Hurtado-Genovés, G
Enrique-Medina, A
Martín-Vañó, S
Casas, V
Nadal, EAC
Real, JT
González-Navarro, H
Martínez-Hervás, S
author Jiménez-Martí, E
author_facet Jiménez-Martí, E
Espinosa-Bellido, C
Alabadi, B
Hurtado-Genovés, G
Enrique-Medina, A
Martín-Vañó, S
Casas, V
Nadal, EAC
Real, JT
González-Navarro, H
Martínez-Hervás, S
author_role author
author2 Espinosa-Bellido, C
Alabadi, B
Hurtado-Genovés, G
Enrique-Medina, A
Martín-Vañó, S
Casas, V
Nadal, EAC
Real, JT
González-Navarro, H
Martínez-Hervás, S
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv atherosclerosis
familial combined hyperlipidaemia
insulin resistance
CX(3)CL1/CX(3)CR1 axis
inflammation
topic atherosclerosis
familial combined hyperlipidaemia
insulin resistance
CX(3)CL1/CX(3)CR1 axis
inflammation
description Background: A major factor in the development of atherosclerosis is the presence of a chronic inflammatory state. The CX(3)CL1/CX(3)CR1 axis has been implicated in the development of atherosclerosis and cardiovascular disease, but until now, scarce data are available regarding the influence of the CX(3)CL1/CX(3)CR1 axis in familial combined hyperlipidaemia (FCH). Since FCH is associated with a high risk of cardiovascular disease, the objective of the present study was to assess the presence of alterations in the CX(3)CL1/CX(3)CR1 axis in patients with FCH and to evaluate the influence of insulin resistance (IR) and sex. Methods: A cohort of 47 subjects with FCH and 38 control subjects was included. We measured the lipid profile, glucose, and insulin levels in plasma, circulating blood CX(3)CL1 levels, and CX(3)CR1 mRNA expression. Carotid IMT and the presence of atheroma plaques were also evaluated. Results: FCH subjects showed significantly higher activation of the CX(3)CL1/CX(3)CR1 axis than controls. In addition, FCH individuals with IR showed the worst profile of inflammation status, higher carotid IMT, and a higher prevalence of atherosclerotic plaque compared to controls and FCH patients without IR. However, sex did not influence the CX3CL1/CX3CR1 axis. Conclusions: FCH patients showed an increased CX(3)CL1/CX(3)CR1 axis, which was positively correlated with IR, but not with sex. These data could partially explain the increased risk of cardiovascular events in primary dyslipidemic patients.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/20453
url https://incliva.portalinvestigacion.com/publicaciones/20453
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Biomedicines
ISSN: 22279059
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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