The Essential Role of IL-17 as the Pathogenetic Link between Psoriasis and Metabolic-Associated Fatty Liver Disease
IL-17; Enfermedad del hígado graso asociada al metabolismo; Psoriasis
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:11351/9142 |
| Acceso en línea: | https://hdl.handle.net/11351/9142 |
| Access Level: | acceso abierto |
| Palabra clave: | Esteatosi hepàtica - Patogènesi Psoriasi Fetge - Metabolisme Interleucines DISEASES::Skin and Connective Tissue Diseases::Skin Diseases::Skin Diseases, Papulosquamous::Psoriasis DISEASES::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver Disease Other subheadings::Other subheadings::Other subheadings::/metabolism CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-17 ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::enfermedades cutáneas papuloescamosas::psoriasis ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hígado graso::esteatosis hepática no alcohólica Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intercelular::citocinas::interleucinas::interleucina-17 |
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The Essential Role of IL-17 as the Pathogenetic Link between Psoriasis and Metabolic-Associated Fatty Liver Disease |
| title |
The Essential Role of IL-17 as the Pathogenetic Link between Psoriasis and Metabolic-Associated Fatty Liver Disease |
| spellingShingle |
The Essential Role of IL-17 as the Pathogenetic Link between Psoriasis and Metabolic-Associated Fatty Liver Disease Olveira Martín, Antonio Esteatosi hepàtica - Patogènesi Psoriasi Fetge - Metabolisme Interleucines DISEASES::Skin and Connective Tissue Diseases::Skin Diseases::Skin Diseases, Papulosquamous::Psoriasis DISEASES::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver Disease Other subheadings::Other subheadings::Other subheadings::/metabolism CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-17 ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::enfermedades cutáneas papuloescamosas::psoriasis ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hígado graso::esteatosis hepática no alcohólica Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intercelular::citocinas::interleucinas::interleucina-17 |
| title_short |
The Essential Role of IL-17 as the Pathogenetic Link between Psoriasis and Metabolic-Associated Fatty Liver Disease |
| title_full |
The Essential Role of IL-17 as the Pathogenetic Link between Psoriasis and Metabolic-Associated Fatty Liver Disease |
| title_fullStr |
The Essential Role of IL-17 as the Pathogenetic Link between Psoriasis and Metabolic-Associated Fatty Liver Disease |
| title_full_unstemmed |
The Essential Role of IL-17 as the Pathogenetic Link between Psoriasis and Metabolic-Associated Fatty Liver Disease |
| title_sort |
The Essential Role of IL-17 as the Pathogenetic Link between Psoriasis and Metabolic-Associated Fatty Liver Disease |
| dc.creator.none.fl_str_mv |
Olveira Martín, Antonio Benlloch, Salvador Suárez-Pérez, Jorge Alonso Armesto, Susana Augustin Recio, Salvador Ampuero, Javier |
| author |
Olveira Martín, Antonio |
| author_facet |
Olveira Martín, Antonio Benlloch, Salvador Suárez-Pérez, Jorge Alonso Armesto, Susana Augustin Recio, Salvador Ampuero, Javier |
| author_role |
author |
| author2 |
Benlloch, Salvador Suárez-Pérez, Jorge Alonso Armesto, Susana Augustin Recio, Salvador Ampuero, Javier |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Olveira A] Department of Digestive Diseases, La Paz University Hospital, Madrid, Spain. [Augustin S] Unitat Hepàtica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Benlloch S] Department of Digestive Diseases, Arnau de Vilanova Hospital, Centro Biomédico en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Valencia, Spain. [Ampuero J] Department of Digestive Diseases, Virgen del Rocío University Hospital, Institute of Biomedicine of Sevilla (IBIS), Department of Medicine, University of Sevilla, Centro Biomédico en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Sevilla, Spain. [Suárez-Pérez JA] Department of Dermatology, Virgen de la Victoria University Hospital, Málaga, Spain. [Armesto S] Department of Dermatology, Marqués de Valdecilla University Hospital, Santander, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Esteatosi hepàtica - Patogènesi Psoriasi Fetge - Metabolisme Interleucines DISEASES::Skin and Connective Tissue Diseases::Skin Diseases::Skin Diseases, Papulosquamous::Psoriasis DISEASES::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver Disease Other subheadings::Other subheadings::Other subheadings::/metabolism CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-17 ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::enfermedades cutáneas papuloescamosas::psoriasis ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hígado graso::esteatosis hepática no alcohólica Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intercelular::citocinas::interleucinas::interleucina-17 |
| topic |
Esteatosi hepàtica - Patogènesi Psoriasi Fetge - Metabolisme Interleucines DISEASES::Skin and Connective Tissue Diseases::Skin Diseases::Skin Diseases, Papulosquamous::Psoriasis DISEASES::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver Disease Other subheadings::Other subheadings::Other subheadings::/metabolism CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-17 ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::enfermedades cutáneas papuloescamosas::psoriasis ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hígado graso::esteatosis hepática no alcohólica Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intercelular::citocinas::interleucinas::interleucina-17 |
| description |
IL-17; Enfermedad del hígado graso asociada al metabolismo; Psoriasis |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023 2023 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/9142 |
| url |
https://hdl.handle.net/11351/9142 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Life;13(2) https://doi.org/10.3390/life13020419 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI |
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MDPI |
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Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869407013005426688 |
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The Essential Role of IL-17 as the Pathogenetic Link between Psoriasis and Metabolic-Associated Fatty Liver DiseaseOlveira Martín, AntonioBenlloch, SalvadorSuárez-Pérez, Jorge AlonsoArmesto, SusanaAugustin Recio, SalvadorAmpuero, JavierEsteatosi hepàtica - PatogènesiPsoriasiFetge - MetabolismeInterleucinesDISEASES::Skin and Connective Tissue Diseases::Skin Diseases::Skin Diseases, Papulosquamous::PsoriasisDISEASES::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver DiseaseOther subheadings::Other subheadings::Other subheadings::/metabolismCHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-17ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::enfermedades cutáneas papuloescamosas::psoriasisENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::hígado graso::esteatosis hepática no alcohólicaOtros calificadores::Otros calificadores::Otros calificadores::/metabolismoCOMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intercelular::citocinas::interleucinas::interleucina-17IL-17; Enfermedad del hígado graso asociada al metabolismo; PsoriasisIL-17; Metabolic-associated fatty liver disease; PsoriasisIL-17; Malaltia del fetge gras associada al metabolisme; PsoriasiInterleukin 17 (IL-17) is an effector cytokine that plays a key role in the pathogenesis of both psoriasis and metabolic-associated fatty liver disease (MAFLD), a condition that is more prevalent and severe in patients with psoriasis. In liver inflammation, IL-17 is mainly produced by CD4+ T (TH17) and CD8+ T cells (Tc17), although numerous other cells (macrophages, natural killer cells, neutrophils and Tγδ cells) also contribute to the production of IL-17. In hepatocytes, IL-17 mediates systemic inflammation and the recruitment of inflammatory cells to the liver, and it is also implicated in the development of fibrosis and insulin resistance. IL-17 levels have been correlated with progression from MAFLD to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Clinical trials have shown that inhibiting IL-17A in patients with psoriasis could potentially contribute to the improvement of metabolic and liver parameters. A better understanding of the key factors involved in the pathogenesis of these chronic inflammatory processes could potentially lead to more efficient treatment for both psoriasis and MAFLD, and help to develop holistic strategies to improve the management of these patients.Financial support for the expert meetings and manuscript preparation were provided by Novartis Farmacéutica S.A.MDPIInstitut Català de la Salut[Olveira A] Department of Digestive Diseases, La Paz University Hospital, Madrid, Spain. [Augustin S] Unitat Hepàtica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Benlloch S] Department of Digestive Diseases, Arnau de Vilanova Hospital, Centro Biomédico en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Valencia, Spain. [Ampuero J] Department of Digestive Diseases, Virgen del Rocío University Hospital, Institute of Biomedicine of Sevilla (IBIS), Department of Medicine, University of Sevilla, Centro Biomédico en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Sevilla, Spain. [Suárez-Pérez JA] Department of Dermatology, Virgen de la Victoria University Hospital, Málaga, Spain. [Armesto S] Department of Dermatology, Marqués de Valdecilla University Hospital, Santander, SpainVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/9142Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésLife;13(2)https://doi.org/10.3390/life13020419Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/91422026-05-29T05:05:01Z |
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15.811543 |