Development of biocomposite polymeric systems loaded with antibacterial nanoparticles for the coating of polypropylene biomaterials

The development of a biocomposite polymeric system for the antibacterial coating of polypropylene mesh materials for hernia repair is reported. Coatings were constituted by a film of chitosan containing randomly dispersed poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles loaded with chlorhexidine...

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Autores: Fernández-Gutiérrez, Mar, Pérez-Köhler, Bárbara, Benito-Martínez, Selma, García-Moreno, Francisca, Pascual, Gemma, García-Fernández, Luis, Aguilar, María Rosa, Vázquez-Lasa, Blanca, Bellón, Juan Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/218463
Acceso en línea:http://hdl.handle.net/10261/218463
Access Level:acceso abierto
Palabra clave:Biocomposites
Chitosan
chlorhexidine
Coatings
hernia
mesh infection
Nanoparticles
PLGA
polypropylene
rifampicin
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spelling Development of biocomposite polymeric systems loaded with antibacterial nanoparticles for the coating of polypropylene biomaterialsFernández-Gutiérrez, MarPérez-Köhler, BárbaraBenito-Martínez, SelmaGarcía-Moreno, FranciscaPascual, GemmaGarcía-Fernández, LuisAguilar, María RosaVázquez-Lasa, BlancaBellón, Juan ManuelBiocompositesChitosanchlorhexidineCoatingsherniamesh infectionNanoparticlesPLGApolypropylenerifampicinThe development of a biocomposite polymeric system for the antibacterial coating of polypropylene mesh materials for hernia repair is reported. Coatings were constituted by a film of chitosan containing randomly dispersed poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles loaded with chlorhexidine or rifampicin. The chlorhexidine-loaded system exhibited a burst release during the first day reaching the release of the loaded drug in three or four days, whereas rifampicin was gradually released for at least 11 days. Both antibacterial coated meshes were highly active against Staphylococcus aureus and Staphylococcus epidermidis (106 CFU/mL), displaying zones of inhibition that lasted for 7 days (chlorhexidine) or 14 days (rifampicin). Apparently, both systems inhibited bacterial growth in the surrounding environment, as well as avoided bacterial adhesion to the mesh surface. These polymeric coatings loaded with biodegradable nanoparticles containing antimicrobials effectively precluded bacterial colonization of the biomaterial. Both biocomposites showed adequate performance and thus could have potential application in the design of antimicrobial coatings for the prophylactic coating of polypropylene materials for hernia repair.The study was supported by Grants SAF2017-89481-P and MAT2017-84277-R from the Spanish Ministry of Science, Innovation and Universities. Financial support from the CIBER-BBN is acknowledged. The study was supported by Grants SAF2017-89481-P and MAT2017-84277-R from the Spanish Ministry of Science, Innovation and Universities. Financial support from the CIBER-BBN is acknowledged (CIBER-BBN Internal Collaborations 2018-2021: “Functionalization of polymer coatings using antimicrobial agents for prevention of mesh infection following hernia surgery” and “Polymeric nanoparticles for the treatment of bacterial diseases”).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/218463reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-89481-Pinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/MAT2017-84277-RSAF2017-89481-P/AEI/10.13039/501100011033MAT2017-84277-R/AEI/10.13039/501100011033https://doi.org/10.3390/polym12081829Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2184632026-05-22T06:33:51Z
dc.title.none.fl_str_mv Development of biocomposite polymeric systems loaded with antibacterial nanoparticles for the coating of polypropylene biomaterials
title Development of biocomposite polymeric systems loaded with antibacterial nanoparticles for the coating of polypropylene biomaterials
spellingShingle Development of biocomposite polymeric systems loaded with antibacterial nanoparticles for the coating of polypropylene biomaterials
Fernández-Gutiérrez, Mar
Biocomposites
Chitosan
chlorhexidine
Coatings
hernia
mesh infection
Nanoparticles
PLGA
polypropylene
rifampicin
title_short Development of biocomposite polymeric systems loaded with antibacterial nanoparticles for the coating of polypropylene biomaterials
title_full Development of biocomposite polymeric systems loaded with antibacterial nanoparticles for the coating of polypropylene biomaterials
title_fullStr Development of biocomposite polymeric systems loaded with antibacterial nanoparticles for the coating of polypropylene biomaterials
title_full_unstemmed Development of biocomposite polymeric systems loaded with antibacterial nanoparticles for the coating of polypropylene biomaterials
title_sort Development of biocomposite polymeric systems loaded with antibacterial nanoparticles for the coating of polypropylene biomaterials
dc.creator.none.fl_str_mv Fernández-Gutiérrez, Mar
Pérez-Köhler, Bárbara
Benito-Martínez, Selma
García-Moreno, Francisca
Pascual, Gemma
García-Fernández, Luis
Aguilar, María Rosa
Vázquez-Lasa, Blanca
Bellón, Juan Manuel
author Fernández-Gutiérrez, Mar
author_facet Fernández-Gutiérrez, Mar
Pérez-Köhler, Bárbara
Benito-Martínez, Selma
García-Moreno, Francisca
Pascual, Gemma
García-Fernández, Luis
Aguilar, María Rosa
Vázquez-Lasa, Blanca
Bellón, Juan Manuel
author_role author
author2 Pérez-Köhler, Bárbara
Benito-Martínez, Selma
García-Moreno, Francisca
Pascual, Gemma
García-Fernández, Luis
Aguilar, María Rosa
Vázquez-Lasa, Blanca
Bellón, Juan Manuel
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Biocomposites
Chitosan
chlorhexidine
Coatings
hernia
mesh infection
Nanoparticles
PLGA
polypropylene
rifampicin
topic Biocomposites
Chitosan
chlorhexidine
Coatings
hernia
mesh infection
Nanoparticles
PLGA
polypropylene
rifampicin
description The development of a biocomposite polymeric system for the antibacterial coating of polypropylene mesh materials for hernia repair is reported. Coatings were constituted by a film of chitosan containing randomly dispersed poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles loaded with chlorhexidine or rifampicin. The chlorhexidine-loaded system exhibited a burst release during the first day reaching the release of the loaded drug in three or four days, whereas rifampicin was gradually released for at least 11 days. Both antibacterial coated meshes were highly active against Staphylococcus aureus and Staphylococcus epidermidis (106 CFU/mL), displaying zones of inhibition that lasted for 7 days (chlorhexidine) or 14 days (rifampicin). Apparently, both systems inhibited bacterial growth in the surrounding environment, as well as avoided bacterial adhesion to the mesh surface. These polymeric coatings loaded with biodegradable nanoparticles containing antimicrobials effectively precluded bacterial colonization of the biomaterial. Both biocomposites showed adequate performance and thus could have potential application in the design of antimicrobial coatings for the prophylactic coating of polypropylene materials for hernia repair.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/218463
url http://hdl.handle.net/10261/218463
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-89481-P
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/MAT2017-84277-R
SAF2017-89481-P/AEI/10.13039/501100011033
MAT2017-84277-R/AEI/10.13039/501100011033
https://doi.org/10.3390/polym12081829
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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