Mechanisms of Resistance to PI3K Inhibitors in Cancer: Adaptive Responses, Drug Tolerance and Cellular Plasticity

Inhibidors de la via PI3K; Mecanismes de resistència

Detalles Bibliográficos
Autores: Wright, Sarah Christine Elisabeth, Vasilevski, Natali, Serra Elizalde, Violeta, Rodon Ahnert, Jordi, Eichhorn, Pieter Johan Adam
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/7210
Acceso en línea:https://hdl.handle.net/11351/7210
http://hdl.handle.net/11351/7210
Access Level:acceso abierto
Palabra clave:Càncer - Tractament
Resistència als medicaments
DISEASES::Neoplasms
Other subheadings::Other subheadings::/therapy
PHENOMENA AND PROCESSES::Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance, Neoplasm
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::/terapia
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::fenómenos farmacológicos::resistencia a medicamentos::resistencia a los antineoplásicos
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spelling Mechanisms of Resistance to PI3K Inhibitors in Cancer: Adaptive Responses, Drug Tolerance and Cellular PlasticityWright, Sarah Christine ElisabethVasilevski, NataliSerra Elizalde, VioletaRodon Ahnert, JordiEichhorn, Pieter Johan AdamCàncer - TractamentResistència als medicamentsDISEASES::NeoplasmsOther subheadings::Other subheadings::/therapyPHENOMENA AND PROCESSES::Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance, NeoplasmENFERMEDADES::neoplasiasOtros calificadores::Otros calificadores::/terapiaFENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::fenómenos farmacológicos::resistencia a medicamentos::resistencia a los antineoplásicosInhibidors de la via PI3K; Mecanismes de resistènciaInhibidores de la vía PI3K; Mecanismos de resistenciaPI3K pathway inhibitors; mechanisms of resistanceThe phosphatidylinositol-3-kinase (PI3K) pathway plays a central role in the regulation of several signalling cascades which regulate biological processes such as cellular growth, survival, proliferation, motility and angiogenesis. The hyperactivation of this pathway is linked to tumour progression and is one of the most common events in human cancers. Additionally, aberrant activation of the PI3K pathway has been demonstrated to limit the effectiveness of a number of anti-tumour agents paving the way for the development and implementation of PI3K inhibitors in the clinic. However, the overall effectiveness of these compounds has been greatly limited by inadequate target engagement due to reactivation of the pathway by compensatory mechanisms. Herein, we review the common adaptive responses that lead to reactivation of the PI3K pathway, therapy resistance and potential strategies to overcome these mechanisms of resistance. Furthermore, we highlight the potential role in changes in cellular plasticity and PI3K inhibitor resistance.The work was funded by a start-up grant provided by Curtin University.MDPIInstitut Català de la Salut[Wright SCE, Vasilevski N] Faculty of Health Sciences, Curtin Medical School, Curtin University, Bentley 6102, Australia. Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley 6102, Australia. [Serra V] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Rodon J] MD Anderson Cancer Center, Investigational Cancer Therapeutics Department, Houston, TX 77030, USA. [Eichhorn PJA] Faculty of Health Sciences, Curtin Medical School, Curtin University, Bentley 6102, Australia. Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley 6102, Australia. Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, SingaporeVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7210http://hdl.handle.net/11351/7210Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCancers;13(7)https://doi.org/10.3390/cancers13071538Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/72102026-05-29T05:05:01Z
dc.title.none.fl_str_mv Mechanisms of Resistance to PI3K Inhibitors in Cancer: Adaptive Responses, Drug Tolerance and Cellular Plasticity
title Mechanisms of Resistance to PI3K Inhibitors in Cancer: Adaptive Responses, Drug Tolerance and Cellular Plasticity
spellingShingle Mechanisms of Resistance to PI3K Inhibitors in Cancer: Adaptive Responses, Drug Tolerance and Cellular Plasticity
Wright, Sarah Christine Elisabeth
Càncer - Tractament
Resistència als medicaments
DISEASES::Neoplasms
Other subheadings::Other subheadings::/therapy
PHENOMENA AND PROCESSES::Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance, Neoplasm
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::/terapia
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::fenómenos farmacológicos::resistencia a medicamentos::resistencia a los antineoplásicos
title_short Mechanisms of Resistance to PI3K Inhibitors in Cancer: Adaptive Responses, Drug Tolerance and Cellular Plasticity
title_full Mechanisms of Resistance to PI3K Inhibitors in Cancer: Adaptive Responses, Drug Tolerance and Cellular Plasticity
title_fullStr Mechanisms of Resistance to PI3K Inhibitors in Cancer: Adaptive Responses, Drug Tolerance and Cellular Plasticity
title_full_unstemmed Mechanisms of Resistance to PI3K Inhibitors in Cancer: Adaptive Responses, Drug Tolerance and Cellular Plasticity
title_sort Mechanisms of Resistance to PI3K Inhibitors in Cancer: Adaptive Responses, Drug Tolerance and Cellular Plasticity
dc.creator.none.fl_str_mv Wright, Sarah Christine Elisabeth
Vasilevski, Natali
Serra Elizalde, Violeta
Rodon Ahnert, Jordi
Eichhorn, Pieter Johan Adam
author Wright, Sarah Christine Elisabeth
author_facet Wright, Sarah Christine Elisabeth
Vasilevski, Natali
Serra Elizalde, Violeta
Rodon Ahnert, Jordi
Eichhorn, Pieter Johan Adam
author_role author
author2 Vasilevski, Natali
Serra Elizalde, Violeta
Rodon Ahnert, Jordi
Eichhorn, Pieter Johan Adam
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Wright SCE, Vasilevski N] Faculty of Health Sciences, Curtin Medical School, Curtin University, Bentley 6102, Australia. Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley 6102, Australia. [Serra V] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Rodon J] MD Anderson Cancer Center, Investigational Cancer Therapeutics Department, Houston, TX 77030, USA. [Eichhorn PJA] Faculty of Health Sciences, Curtin Medical School, Curtin University, Bentley 6102, Australia. Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley 6102, Australia. Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Càncer - Tractament
Resistència als medicaments
DISEASES::Neoplasms
Other subheadings::Other subheadings::/therapy
PHENOMENA AND PROCESSES::Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance, Neoplasm
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::/terapia
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::fenómenos farmacológicos::resistencia a medicamentos::resistencia a los antineoplásicos
topic Càncer - Tractament
Resistència als medicaments
DISEASES::Neoplasms
Other subheadings::Other subheadings::/therapy
PHENOMENA AND PROCESSES::Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance, Neoplasm
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::/terapia
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::fenómenos farmacológicos::resistencia a medicamentos::resistencia a los antineoplásicos
description Inhibidors de la via PI3K; Mecanismes de resistència
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7210
http://hdl.handle.net/11351/7210
url https://hdl.handle.net/11351/7210
http://hdl.handle.net/11351/7210
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cancers;13(7)
https://doi.org/10.3390/cancers13071538
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406979939631104
score 15,811543

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