Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
MISEV Consortium: et al.
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/380261 |
| Acceso en línea: | http://hdl.handle.net/10261/380261 https://api.elsevier.com/content/abstract/scopus_id/85183359756 |
| Access Level: | acceso abierto |
| Palabra clave: | MISEV Ectosomes Exosomes Extracellular particles Extracellular vesicles Guidelines Microparticles Microvesicles Minimal information requirements Reproducibility Rigor Standardisation |
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Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approachesWelsh, Joshua A.Goberdhan, Deborah C. I.O'Driscoll, LorraineBuzas, Edit IBlenkiron, CherieBussolati, BenedettaCai, HoujianDi Vizio, DoloresDriedonks, Tom A. P.Erdbrügger, UtaFalcon-Perez, Juan M.Fu, Qing-LingHill, Andrew F.Lenassi, MetkaLim, Sai KiangMahoney, Mỹ GMohanty, SujataMöller, AndreasNieuwland, RienkOchiya, TakahiroSahoo, SusmitaTorrecilhas, Ana C.Zheng, LeiZijlstra, AndriesAbuelreich, SarahBagabas, ReemBergese, PaoloBridges, Esther M.Brucale, MarcoBurger, DylanCarney, Randy P.Cocucci, EmanueleCrescitelli, RossellaHanser, EdveenaHarris, Adrian L.Haughey, Norman J.Hendrix, AnIvanov, Alexander R.Jovanovic-Talisman, TijanaKruh-Garcia, Nicole A.Ku'ulei-Lyn Faustino, VroniqaKyburz, DiegoLässer, CeciliaLennon, Kathleen M.Lötvall, JanMaddox, Adam L.Martens-Uzunova, Elena S.Mizenko, Rachel R.Newman, Lauren A.Ridolfi, AndreaRohde, EvaRojalin, TatuRowland, AndrewSaftics, AndrasSandau, Ursula S.Saugstad, Julie A.Shekari, FaezehSwift, SimonTer-Ovanesyan, DmitryTosar, Juan P.Useckaite, ZivileValle, FrancescoVarga, Zoltanvan der Pol, Edwinvan Herwijnen, Martijn J. C.Wauben, Marca H. M.Wehman, Ann M.Williams, SarahZendrini, AndreaZimmerman, Alan J.Théry, ClotildeWitwer, Kenneth W.MISEV ConsortiumMISEVEctosomesExosomesExtracellular particlesExtracellular vesiclesGuidelinesMicroparticlesMicrovesiclesMinimal information requirementsReproducibilityRigorStandardisationMISEV Consortium: et al.Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly.Peer reviewedJohn Wiley & SonsWelsh, Joshua A. [0000-0002-1097-9756]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/380261https://api.elsevier.com/content/abstract/scopus_id/85183359756reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1002/jev2.12404Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3802612026-05-22T06:33:51Z |
| dc.title.none.fl_str_mv |
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches |
| title |
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches |
| spellingShingle |
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches Welsh, Joshua A. MISEV Ectosomes Exosomes Extracellular particles Extracellular vesicles Guidelines Microparticles Microvesicles Minimal information requirements Reproducibility Rigor Standardisation |
| title_short |
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches |
| title_full |
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches |
| title_fullStr |
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches |
| title_full_unstemmed |
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches |
| title_sort |
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches |
| dc.creator.none.fl_str_mv |
Welsh, Joshua A. Goberdhan, Deborah C. I. O'Driscoll, Lorraine Buzas, Edit I Blenkiron, Cherie Bussolati, Benedetta Cai, Houjian Di Vizio, Dolores Driedonks, Tom A. P. Erdbrügger, Uta Falcon-Perez, Juan M. Fu, Qing-Ling Hill, Andrew F. Lenassi, Metka Lim, Sai Kiang Mahoney, Mỹ G Mohanty, Sujata Möller, Andreas Nieuwland, Rienk Ochiya, Takahiro Sahoo, Susmita Torrecilhas, Ana C. Zheng, Lei Zijlstra, Andries Abuelreich, Sarah Bagabas, Reem Bergese, Paolo Bridges, Esther M. Brucale, Marco Burger, Dylan Carney, Randy P. Cocucci, Emanuele Crescitelli, Rossella Hanser, Edveena Harris, Adrian L. Haughey, Norman J. Hendrix, An Ivanov, Alexander R. Jovanovic-Talisman, Tijana Kruh-Garcia, Nicole A. Ku'ulei-Lyn Faustino, Vroniqa Kyburz, Diego Lässer, Cecilia Lennon, Kathleen M. Lötvall, Jan Maddox, Adam L. Martens-Uzunova, Elena S. Mizenko, Rachel R. Newman, Lauren A. Ridolfi, Andrea Rohde, Eva Rojalin, Tatu Rowland, Andrew Saftics, Andras Sandau, Ursula S. Saugstad, Julie A. Shekari, Faezeh Swift, Simon Ter-Ovanesyan, Dmitry Tosar, Juan P. Useckaite, Zivile Valle, Francesco Varga, Zoltan van der Pol, Edwin van Herwijnen, Martijn J. C. Wauben, Marca H. M. Wehman, Ann M. Williams, Sarah Zendrini, Andrea Zimmerman, Alan J. Théry, Clotilde Witwer, Kenneth W. MISEV Consortium |
| author |
Welsh, Joshua A. |
| author_facet |
Welsh, Joshua A. Goberdhan, Deborah C. I. O'Driscoll, Lorraine Buzas, Edit I Blenkiron, Cherie Bussolati, Benedetta Cai, Houjian Di Vizio, Dolores Driedonks, Tom A. P. Erdbrügger, Uta Falcon-Perez, Juan M. Fu, Qing-Ling Hill, Andrew F. Lenassi, Metka Lim, Sai Kiang Mahoney, Mỹ G Mohanty, Sujata Möller, Andreas Nieuwland, Rienk Ochiya, Takahiro Sahoo, Susmita Torrecilhas, Ana C. Zheng, Lei Zijlstra, Andries Abuelreich, Sarah Bagabas, Reem Bergese, Paolo Bridges, Esther M. Brucale, Marco Burger, Dylan Carney, Randy P. Cocucci, Emanuele Crescitelli, Rossella Hanser, Edveena Harris, Adrian L. Haughey, Norman J. Hendrix, An Ivanov, Alexander R. Jovanovic-Talisman, Tijana Kruh-Garcia, Nicole A. Ku'ulei-Lyn Faustino, Vroniqa Kyburz, Diego Lässer, Cecilia Lennon, Kathleen M. Lötvall, Jan Maddox, Adam L. Martens-Uzunova, Elena S. Mizenko, Rachel R. Newman, Lauren A. Ridolfi, Andrea Rohde, Eva Rojalin, Tatu Rowland, Andrew Saftics, Andras Sandau, Ursula S. Saugstad, Julie A. Shekari, Faezeh Swift, Simon Ter-Ovanesyan, Dmitry Tosar, Juan P. Useckaite, Zivile Valle, Francesco Varga, Zoltan van der Pol, Edwin van Herwijnen, Martijn J. C. Wauben, Marca H. M. Wehman, Ann M. Williams, Sarah Zendrini, Andrea Zimmerman, Alan J. Théry, Clotilde Witwer, Kenneth W. MISEV Consortium |
| author_role |
author |
| author2 |
Goberdhan, Deborah C. I. O'Driscoll, Lorraine Buzas, Edit I Blenkiron, Cherie Bussolati, Benedetta Cai, Houjian Di Vizio, Dolores Driedonks, Tom A. P. Erdbrügger, Uta Falcon-Perez, Juan M. Fu, Qing-Ling Hill, Andrew F. Lenassi, Metka Lim, Sai Kiang Mahoney, Mỹ G Mohanty, Sujata Möller, Andreas Nieuwland, Rienk Ochiya, Takahiro Sahoo, Susmita Torrecilhas, Ana C. Zheng, Lei Zijlstra, Andries Abuelreich, Sarah Bagabas, Reem Bergese, Paolo Bridges, Esther M. Brucale, Marco Burger, Dylan Carney, Randy P. Cocucci, Emanuele Crescitelli, Rossella Hanser, Edveena Harris, Adrian L. Haughey, Norman J. Hendrix, An Ivanov, Alexander R. Jovanovic-Talisman, Tijana Kruh-Garcia, Nicole A. Ku'ulei-Lyn Faustino, Vroniqa Kyburz, Diego Lässer, Cecilia Lennon, Kathleen M. Lötvall, Jan Maddox, Adam L. Martens-Uzunova, Elena S. Mizenko, Rachel R. Newman, Lauren A. Ridolfi, Andrea Rohde, Eva Rojalin, Tatu Rowland, Andrew Saftics, Andras Sandau, Ursula S. Saugstad, Julie A. Shekari, Faezeh Swift, Simon Ter-Ovanesyan, Dmitry Tosar, Juan P. Useckaite, Zivile Valle, Francesco Varga, Zoltan van der Pol, Edwin van Herwijnen, Martijn J. C. Wauben, Marca H. M. Wehman, Ann M. Williams, Sarah Zendrini, Andrea Zimmerman, Alan J. Théry, Clotilde Witwer, Kenneth W. MISEV Consortium |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Welsh, Joshua A. [0000-0002-1097-9756] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
MISEV Ectosomes Exosomes Extracellular particles Extracellular vesicles Guidelines Microparticles Microvesicles Minimal information requirements Reproducibility Rigor Standardisation |
| topic |
MISEV Ectosomes Exosomes Extracellular particles Extracellular vesicles Guidelines Microparticles Microvesicles Minimal information requirements Reproducibility Rigor Standardisation |
| description |
MISEV Consortium: et al. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/380261 https://api.elsevier.com/content/abstract/scopus_id/85183359756 |
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http://hdl.handle.net/10261/380261 https://api.elsevier.com/content/abstract/scopus_id/85183359756 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
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https://doi.org/10.1002/jev2.12404 Sí |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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John Wiley & Sons |
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John Wiley & Sons |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Consejo Superior de Investigaciones Científicas (CSIC) |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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15.811543 |