What value do NMDA receptor antagonist models of schizophrenia have for novel drug discovery?
[Introduction] N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP) and ketamine can induce schizophrenic features in healthy volunteers and exacerbate the symptoms in schizophrenic patients. Furthermore, the administration of NMDA receptor antagonists to rodents produces hyp...
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:dnet:digitalcsic_::e002270471cc96462c8b92634d793986 |
| Acceso en línea: | http://hdl.handle.net/10261/426714 |
| Access Level: | acceso abierto |
| Palabra clave: | Animal model Glutamate Serotonin Dopamine Psychosis Biomarker Neuroimaging Electrophysiology |
| Sumario: | [Introduction] N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP) and ketamine can induce schizophrenic features in healthy volunteers and exacerbate the symptoms in schizophrenic patients. Furthermore, the administration of NMDA receptor antagonists to rodents produces hyperlocomotion. The ability of drugs to attenuate this hyperlocomotion correlates with clinical efficacy on positive symptoms. Similarly, social withdrawal is taken as a surrogate of unsociability in schizophrenia. Furthermore, first episode psychosis and chronic schizophrenia can be modeled by acute and subchronic administration of NMDA receptor blockers, respectively. Therefore, the NMDA hypofunction model provides a powerful tool to develop new therapeutic strategies in drug discovery to treat schizophrenia. |
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