Maternal occupational exposures and fetal growth in a Spanish birth cohort

While the epidemiologic literature suggests certain maternal occupational exposures may be associated with reduced measures of size at birth, the occupational literature employing fetal biometry data to assess fetal growth is sparse. The present study examines associations between maternal occupatio...

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Detalles Bibliográficos
Autores: Ish, Jennifer, Gimeno Ruiz de Porras, David, Symanski, Elaine, Ballester Díez, Ferran, Casas Sanahuja, Maribel, Delclos, George L., Guxens Junyent, Mònica, Ibarluzea, Jesús, Iñiguez, Carmen, Santa Marina, Loreto, Swartz, Michael D., Whitworth, Kristina W.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/55211
Acceso en línea:http://hdl.handle.net/10230/55211
http://dx.doi.org/10.1371/journal.pone.0264530
Access Level:acceso abierto
Palabra clave:Pregnancy
Birth
Jobs
Antigen-presenting cells
Phthalates
Psychological stress
Chemical disruption
Cohort studies
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network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Maternal occupational exposures and fetal growth in a Spanish birth cohort
title Maternal occupational exposures and fetal growth in a Spanish birth cohort
spellingShingle Maternal occupational exposures and fetal growth in a Spanish birth cohort
Ish, Jennifer
Pregnancy
Birth
Jobs
Antigen-presenting cells
Phthalates
Psychological stress
Chemical disruption
Cohort studies
title_short Maternal occupational exposures and fetal growth in a Spanish birth cohort
title_full Maternal occupational exposures and fetal growth in a Spanish birth cohort
title_fullStr Maternal occupational exposures and fetal growth in a Spanish birth cohort
title_full_unstemmed Maternal occupational exposures and fetal growth in a Spanish birth cohort
title_sort Maternal occupational exposures and fetal growth in a Spanish birth cohort
dc.creator.none.fl_str_mv Ish, Jennifer
Gimeno Ruiz de Porras, David
Symanski, Elaine
Ballester Díez, Ferran
Casas Sanahuja, Maribel
Delclos, George L.
Guxens Junyent, Mònica
Ibarluzea, Jesús
Iñiguez, Carmen
Santa Marina, Loreto
Swartz, Michael D.
Whitworth, Kristina W.
author Ish, Jennifer
author_facet Ish, Jennifer
Gimeno Ruiz de Porras, David
Symanski, Elaine
Ballester Díez, Ferran
Casas Sanahuja, Maribel
Delclos, George L.
Guxens Junyent, Mònica
Ibarluzea, Jesús
Iñiguez, Carmen
Santa Marina, Loreto
Swartz, Michael D.
Whitworth, Kristina W.
author_role author
author2 Gimeno Ruiz de Porras, David
Symanski, Elaine
Ballester Díez, Ferran
Casas Sanahuja, Maribel
Delclos, George L.
Guxens Junyent, Mònica
Ibarluzea, Jesús
Iñiguez, Carmen
Santa Marina, Loreto
Swartz, Michael D.
Whitworth, Kristina W.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pregnancy
Birth
Jobs
Antigen-presenting cells
Phthalates
Psychological stress
Chemical disruption
Cohort studies
topic Pregnancy
Birth
Jobs
Antigen-presenting cells
Phthalates
Psychological stress
Chemical disruption
Cohort studies
description While the epidemiologic literature suggests certain maternal occupational exposures may be associated with reduced measures of size at birth, the occupational literature employing fetal biometry data to assess fetal growth is sparse. The present study examines associations between maternal occupational exposures and ultrasound-measured fetal growth. We included 1,739 singleton pregnancies from the INfancia y Medio Ambiente (INMA) project (2003-2008). At 32 weeks of pregnancy, interviewers ascertained mothers' employment status and assessed job-related physical loads, work schedules, and job strain during pregnancy. Job titles were linked to a job-exposure matrix to estimate exposure to 10 endocrine disrupting chemical (EDC) groups. We calculated z-scores from longitudinal growth curves representing trajectories from 0-12, 12-20 and 20-34 gestational weeks for abdominal circumference (AC), biparietal diameter (BPD), femur length (FL), and estimated fetal weight (EFW). Linear mixed models clustered by IMNA region (i.e., Gipuzkoa, Sabadell, Valencia) were used to examine associations between occupational exposures and fetal growth. Effect estimates are presented as percentage change in fetal growth. There was limited evidence of associations between work-related non-chemical stressors and fetal growth. We observed associations of similar magnitude between multiple EDC groups and decreased EFW trajectories during 20-34 gestational weeks (phthalates: -1.4% [-3.5, 0.6%]; alkylphenolic compounds (APCs): -1.1% [-2.3, 0.1%]; miscellaneous chemicals: -1.5% [-3.7, 0.8%]), while miscellaneous chemicals were associated with increased BPD from 12-20 weeks (2.1% [0.8, 3.5%]). Notably, 67% of women exposed to phthalates were hairdressers; 68% of women exposed to APCs worked as domestic cleaners. In conclusion, we found limited evidence that maternal occupational exposures impact fetal growth. Further research should consider the combined impact of multiple workplace exposures.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/55211
http://dx.doi.org/10.1371/journal.pone.0264530
url http://hdl.handle.net/10230/55211
http://dx.doi.org/10.1371/journal.pone.0264530
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PLoS One. 2022 Apr 7;17(4):e0264530
info:eu-repo/grantAgreement/EC/FP7/282957
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
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spelling Maternal occupational exposures and fetal growth in a Spanish birth cohortIsh, JenniferGimeno Ruiz de Porras, DavidSymanski, ElaineBallester Díez, FerranCasas Sanahuja, MaribelDelclos, George L.Guxens Junyent, MònicaIbarluzea, JesúsIñiguez, CarmenSanta Marina, LoretoSwartz, Michael D.Whitworth, Kristina W.PregnancyBirthJobsAntigen-presenting cellsPhthalatesPsychological stressChemical disruptionCohort studiesWhile the epidemiologic literature suggests certain maternal occupational exposures may be associated with reduced measures of size at birth, the occupational literature employing fetal biometry data to assess fetal growth is sparse. The present study examines associations between maternal occupational exposures and ultrasound-measured fetal growth. We included 1,739 singleton pregnancies from the INfancia y Medio Ambiente (INMA) project (2003-2008). At 32 weeks of pregnancy, interviewers ascertained mothers' employment status and assessed job-related physical loads, work schedules, and job strain during pregnancy. Job titles were linked to a job-exposure matrix to estimate exposure to 10 endocrine disrupting chemical (EDC) groups. We calculated z-scores from longitudinal growth curves representing trajectories from 0-12, 12-20 and 20-34 gestational weeks for abdominal circumference (AC), biparietal diameter (BPD), femur length (FL), and estimated fetal weight (EFW). Linear mixed models clustered by IMNA region (i.e., Gipuzkoa, Sabadell, Valencia) were used to examine associations between occupational exposures and fetal growth. Effect estimates are presented as percentage change in fetal growth. There was limited evidence of associations between work-related non-chemical stressors and fetal growth. We observed associations of similar magnitude between multiple EDC groups and decreased EFW trajectories during 20-34 gestational weeks (phthalates: -1.4% [-3.5, 0.6%]; alkylphenolic compounds (APCs): -1.1% [-2.3, 0.1%]; miscellaneous chemicals: -1.5% [-3.7, 0.8%]), while miscellaneous chemicals were associated with increased BPD from 12-20 weeks (2.1% [0.8, 3.5%]). Notably, 67% of women exposed to phthalates were hairdressers; 68% of women exposed to APCs worked as domestic cleaners. In conclusion, we found limited evidence that maternal occupational exposures impact fetal growth. Further research should consider the combined impact of multiple workplace exposures.This work was supported by grants from the National Institutes of Health/National Institute of Environmental Health Sciences (R01ES028842, PI: KWW), Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/0867, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, PI17/00663, FIS-PI18/01142 incl. FEDER funds; Miguel Servet-FEDER CP11/00178, CP15/00025, CPII16/00051, CPII18/00018, and CP16/00128), Generalitat de Catalunya-CIRIT 1999SGR 00241, EU Commission (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249) and Conselleria d’Educació AICO/2020/285, and Alicia Koplowitz Foundation 2017, Department of Health of the Basque Government (2005111093), Provincial Government of Gipuzkoa (DFG06/002), and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain). We also acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. JI, DGRdP, and GLD were partly supported by the Southwest Center for Occupational and Environmental Health (SWCOEH), the Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health (NIOSH) Education and Research Center (T42OH008421) at The University of Texas Health Science Center at Houston (UTHealth) School of Public Health. KWW and ES were supported in part by the by the Gulf Coast Center for Precision Environmental Health (GC-CPEH) at Baylor College of Medicine (P30ES030285). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.Public Library of Science (PLoS)202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/55211http://dx.doi.org/10.1371/journal.pone.0264530reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPLoS One. 2022 Apr 7;17(4):e0264530info:eu-repo/grantAgreement/EC/FP7/282957© 2022 Ish et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/552112026-05-29T05:05:01Z
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