Porcine Digestible Peptides (PDP) in Weanling Diets Regulates the Expression of Genes Involved in Gut Barrier Function, Immune Response and Nutrient Transport in Nursery Pigs

This study was conducted to investigate the effects of dietary supplementation of porcine digestible peptides (PDP), spray-dried plasma (SDP), or a combination of both, on growth performance and the expression of genes related to intestinal function of weaned pigs. A total of 180 piglets (trial 1) a...

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Detalles Bibliográficos
Autores: González Solé, Francesc|||0000-0002-3469-6240, Criado Mesas, Lourdes|||0000-0002-1115-4131, Villodre, Carmen, Coloma Garcia, Wellington|||0000-0003-3182-2085, Farré, Mercè|||0000-0002-4184-5160, Borda, Elisabet|||0000-0001-8028-7459, Pérez-Cano, Francisco J.|||0000-0001-6243-9164, Folch, Josep M.|||0000-0003-3689-1303, Solà Oriol, David|||0000-0001-8365-340X, Pérez Hernández, José Francisco|||0000-0001-8853-8945
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:236051
Acceso en línea:https://ddd.uab.cat/record/236051
https://dx.doi.org/urn:doi:10.3390/ani10122368
Access Level:acceso abierto
Palabra clave:Gene expression
High throughput RT-qPCR
Intestinal function
Piglet
Porcine digestible peptides
Descripción
Sumario:This study was conducted to investigate the effects of dietary supplementation of porcine digestible peptides (PDP), spray-dried plasma (SDP), or a combination of both, on growth performance and the expression of genes related to intestinal function of weaned pigs. A total of 180 piglets (trial 1) and 198 piglets (trial 2) were used to evaluate the partial substitution of soybean ingredients with 2% SDP or 2% PDP (trial 1), and with 3% SDP or the combination of 1% SDP and 2% PDP (SDP-PDP; trial 2) during the pre-starter period (0-14 days). The gene expression of 56 genes was quantified in a qPCR platform in jejunum and ileum samples obtained from piglets 14 d after weaning (trial 2). Piglets fed SDP, PDP and SDP-PDP had a higher body weight (BW), average daily gain (ADG) and feed efficiency (G:F) than the soybean control on day 14 (p < 0.05). In addition, the combination of SDP and PDP upregulated ten genes in jejunum samples (p < 0.05) related to intestinal function. More research is needed to confirm that gene expression upregulation by PDP in combination with SDP has an impact on intestinal function and to elucidate its underlying mechanisms.

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