Phages in the human body

Bacteriophages, viruses that infect bacteria, have re-emerged as powerful regulators of bacterial populations in natural ecosystems. Phages invade the human body, just as they do other natural environments, to such an extent that they are the most numerous group in the human virome. This was only re...

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Detalhes bibliográficos
Autores: Navarro, Ferran, Muniesa Pérez, Ma. Teresa
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/120554
Acesso em linha:https://hdl.handle.net/2445/120554
Access Level:acceso abierto
Palavra-chave:Homeòstasi
Bacteriòfags
Homeostasis
Bacteriophages
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spelling Phages in the human bodyNavarro, FerranMuniesa Pérez, Ma. TeresaHomeòstasiBacteriòfagsHomeostasisBacteriophagesBacteriophages, viruses that infect bacteria, have re-emerged as powerful regulators of bacterial populations in natural ecosystems. Phages invade the human body, just as they do other natural environments, to such an extent that they are the most numerous group in the human virome. This was only revealed in recent metagenomic studies, despite the fact that the presence of phages in the human body was reported decades ago. The influence of the presence of phages in humans has yet to be evaluated; but as in marine environments, a clear role in the regulation of bacterial populations could be envisaged, that might have an impact on human health. Moreover, phages are excellent vehicles of genetic transfer, and they contribute to the evolution of bacterial cells in the human body by spreading and acquiring DNA horizontally. The abundance of phages in the human body does not pass unnoticed and the immune system reacts to them, although it is not clear to what extent. Finally, the presence of phages in human samples, which most of the time is not considered, can influence and bias microbiological and molecular results; and, in view of the evidences, some studies suggest that more attention needs to be paid to their interference.Frontiers Media2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/120554Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fmicb.2017.00566Frontiers in Microbiology, 2017, vol. 8, num. 566https://doi.org/10.3389/fmicb.2017.00566cc-by (c) Navarro, Ferran et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1205542026-05-27T06:46:51Z
dc.title.none.fl_str_mv Phages in the human body
title Phages in the human body
spellingShingle Phages in the human body
Navarro, Ferran
Homeòstasi
Bacteriòfags
Homeostasis
Bacteriophages
title_short Phages in the human body
title_full Phages in the human body
title_fullStr Phages in the human body
title_full_unstemmed Phages in the human body
title_sort Phages in the human body
dc.creator.none.fl_str_mv Navarro, Ferran
Muniesa Pérez, Ma. Teresa
author Navarro, Ferran
author_facet Navarro, Ferran
Muniesa Pérez, Ma. Teresa
author_role author
author2 Muniesa Pérez, Ma. Teresa
author2_role author
dc.subject.none.fl_str_mv Homeòstasi
Bacteriòfags
Homeostasis
Bacteriophages
topic Homeòstasi
Bacteriòfags
Homeostasis
Bacteriophages
description Bacteriophages, viruses that infect bacteria, have re-emerged as powerful regulators of bacterial populations in natural ecosystems. Phages invade the human body, just as they do other natural environments, to such an extent that they are the most numerous group in the human virome. This was only revealed in recent metagenomic studies, despite the fact that the presence of phages in the human body was reported decades ago. The influence of the presence of phages in humans has yet to be evaluated; but as in marine environments, a clear role in the regulation of bacterial populations could be envisaged, that might have an impact on human health. Moreover, phages are excellent vehicles of genetic transfer, and they contribute to the evolution of bacterial cells in the human body by spreading and acquiring DNA horizontally. The abundance of phages in the human body does not pass unnoticed and the immune system reacts to them, although it is not clear to what extent. Finally, the presence of phages in human samples, which most of the time is not considered, can influence and bias microbiological and molecular results; and, in view of the evidences, some studies suggest that more attention needs to be paid to their interference.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/120554
url https://hdl.handle.net/2445/120554
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fmicb.2017.00566
Frontiers in Microbiology, 2017, vol. 8, num. 566
https://doi.org/10.3389/fmicb.2017.00566
dc.rights.none.fl_str_mv cc-by (c) Navarro, Ferran et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Navarro, Ferran et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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