No differences of immune activation and microbial translocation among HIV-infected children receiving combined antiretroviral therapy or protease inhibitor monotherapy.

This is a cross-sectional study of 15 aviremic chronic HIV-infected children revealing no differences in immune activation (IA; HLA-DRCD38 CD4 and CD8 T cells, and sCD14) and microbial translocation (MT; lipopolysaccharides (LPS) and 16S rDNA) among HIV-infected patients under combined antiretrovira...

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Autores: Falcon Neyra, Lola, Benmarzouk-Hidalgo, Omar J., Madrid, Lola, Noguera Julian, Antoni, Fortuny Guasch, Claudia, Neth, Olaf, López Cortés, Luis F.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/105795
Acceso en línea:https://hdl.handle.net/2445/105795
Access Level:acceso abierto
Palabra clave:Infants
Infeccions per VIH
Antiretrovirals
Inhibidors enzimàtics
Children
HIV infections
Antiretroviral agents
Enzyme inhibitors
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spelling No differences of immune activation and microbial translocation among HIV-infected children receiving combined antiretroviral therapy or protease inhibitor monotherapy.Falcon Neyra, LolaBenmarzouk-Hidalgo, Omar J.Madrid, LolaNoguera Julian, AntoniFortuny Guasch, ClaudiaNeth, OlafLópez Cortés, Luis F.InfantsInfeccions per VIHAntiretroviralsInhibidors enzimàticsChildrenHIV infectionsAntiretroviral agentsEnzyme inhibitorsThis is a cross-sectional study of 15 aviremic chronic HIV-infected children revealing no differences in immune activation (IA; HLA-DRCD38 CD4 and CD8 T cells, and sCD14) and microbial translocation (MT; lipopolysaccharides (LPS) and 16S rDNA) among HIV-infected patients under combined antiretroviral treatment (cART; n = 10) or ritonavir-boosted protease inhibitor monotherapy (mtPI/rtv; n = 5). In both cases, IA and MT were lower in healthy control children (n = 32). This observational study suggests that ritonavir boosted protease inhibitor monotherapy (mtPI/rtv) is not associated with an increased state of IA or MT as compared with children receiving cART.Lippincott, Williams & Wilkins. Wolters Kluwer Health2017201720152017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion4 p.application/pdfhttps://hdl.handle.net/2445/105795Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1097/MD.0000000000000521Medicine, 2015, vol. 94, num. 11, p. e521https://doi.org/10.1097/MD.0000000000000521cc-by (c) Falcon-Neyra, L. et al., 2015http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1057952026-05-29T05:05:01Z
dc.title.none.fl_str_mv No differences of immune activation and microbial translocation among HIV-infected children receiving combined antiretroviral therapy or protease inhibitor monotherapy.
title No differences of immune activation and microbial translocation among HIV-infected children receiving combined antiretroviral therapy or protease inhibitor monotherapy.
spellingShingle No differences of immune activation and microbial translocation among HIV-infected children receiving combined antiretroviral therapy or protease inhibitor monotherapy.
Falcon Neyra, Lola
Infants
Infeccions per VIH
Antiretrovirals
Inhibidors enzimàtics
Children
HIV infections
Antiretroviral agents
Enzyme inhibitors
title_short No differences of immune activation and microbial translocation among HIV-infected children receiving combined antiretroviral therapy or protease inhibitor monotherapy.
title_full No differences of immune activation and microbial translocation among HIV-infected children receiving combined antiretroviral therapy or protease inhibitor monotherapy.
title_fullStr No differences of immune activation and microbial translocation among HIV-infected children receiving combined antiretroviral therapy or protease inhibitor monotherapy.
title_full_unstemmed No differences of immune activation and microbial translocation among HIV-infected children receiving combined antiretroviral therapy or protease inhibitor monotherapy.
title_sort No differences of immune activation and microbial translocation among HIV-infected children receiving combined antiretroviral therapy or protease inhibitor monotherapy.
dc.creator.none.fl_str_mv Falcon Neyra, Lola
Benmarzouk-Hidalgo, Omar J.
Madrid, Lola
Noguera Julian, Antoni
Fortuny Guasch, Claudia
Neth, Olaf
López Cortés, Luis F.
author Falcon Neyra, Lola
author_facet Falcon Neyra, Lola
Benmarzouk-Hidalgo, Omar J.
Madrid, Lola
Noguera Julian, Antoni
Fortuny Guasch, Claudia
Neth, Olaf
López Cortés, Luis F.
author_role author
author2 Benmarzouk-Hidalgo, Omar J.
Madrid, Lola
Noguera Julian, Antoni
Fortuny Guasch, Claudia
Neth, Olaf
López Cortés, Luis F.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Infants
Infeccions per VIH
Antiretrovirals
Inhibidors enzimàtics
Children
HIV infections
Antiretroviral agents
Enzyme inhibitors
topic Infants
Infeccions per VIH
Antiretrovirals
Inhibidors enzimàtics
Children
HIV infections
Antiretroviral agents
Enzyme inhibitors
description This is a cross-sectional study of 15 aviremic chronic HIV-infected children revealing no differences in immune activation (IA; HLA-DRCD38 CD4 and CD8 T cells, and sCD14) and microbial translocation (MT; lipopolysaccharides (LPS) and 16S rDNA) among HIV-infected patients under combined antiretroviral treatment (cART; n = 10) or ritonavir-boosted protease inhibitor monotherapy (mtPI/rtv; n = 5). In both cases, IA and MT were lower in healthy control children (n = 32). This observational study suggests that ritonavir boosted protease inhibitor monotherapy (mtPI/rtv) is not associated with an increased state of IA or MT as compared with children receiving cART.
publishDate 2015
dc.date.none.fl_str_mv 2015
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/105795
url https://hdl.handle.net/2445/105795
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1097/MD.0000000000000521
Medicine, 2015, vol. 94, num. 11, p. e521
https://doi.org/10.1097/MD.0000000000000521
dc.rights.none.fl_str_mv cc-by (c) Falcon-Neyra, L. et al., 2015
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Falcon-Neyra, L. et al., 2015
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 4 p.
application/pdf
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins. Wolters Kluwer Health
publisher.none.fl_str_mv Lippincott, Williams & Wilkins. Wolters Kluwer Health
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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