Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease

INTRODUCTION A biphasic model for brain structural changes in preclinical Alzheimer's disease (AD) could reconcile some conflicting and paradoxical findings in observational studies and anti-amyloid clinical trials. METHODS In this study we tested this model fitting linear versus quadratic traj...

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Detalles Bibliográficos
Autores: Montal, V, Vilaplana, E, Pegueroles, J, Bejanin, A, Alcolea, D, Carmona-Iragui, M, Clarimon, J, Levin, J, Cruchaga, C, Graff-Radford, NR, Noble, JM, Lee, JH, Allegri, R, Karch, CM, Laske, C, Schofield, PR, Salloway, S, Ances, B, Benzinger, T, McDale, E, Bateman, R, Blesa, R, Sanchez-Valle, R, Lleo, A, Fortea, J, DIAN
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p4838
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4838
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043974
Access Level:acceso abierto
Palabra clave:Alzheimer&apos
s disease
autosomal&#8208
dominant Alzheimer&apos
biphasic cortical changes
cortical diffusivity
magnetic resonance imaging
preclinical Alzheimer&apos
Descripción
Sumario:INTRODUCTION A biphasic model for brain structural changes in preclinical Alzheimer's disease (AD) could reconcile some conflicting and paradoxical findings in observational studies and anti-amyloid clinical trials. METHODS In this study we tested this model fitting linear versus quadratic trajectories and computed the timing of the inflection points vertexwise of cortical thickness and cortical diffusivity-a novel marker of cortical microstructure-changes in 389 participants from the Dominantly Inherited Alzheimer Network. RESULTS In early preclinical AD, between 20 and 15 years before estimated symptom onset, we found increases in cortical thickness and decreases in cortical diffusivity followed by cortical thinning and cortical diffusivity increases in later preclinical and symptomatic stages. The inflection points 16 to 19 years before estimated symptom onset are in agreement with the start of tau biomarker alterations. DISCUSSION These findings confirm a biphasic trajectory for brain structural changes and have direct implications when interpreting magnetic resonance imaging measures in preventive AD clinical trials.

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