Vitamin D and the epithelial to mesenchymal transition

Several studies support reciprocal regulation between the active vitamin D derivative 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) and the epithelial to mesenchymal transition (EMT). Thus, 1,25(OH)2D3 inhibits EMT via the induction of a variety of target genes that encode cell adhesion and polarity prote...

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Detalles Bibliográficos
Autores: Larriba, María Jesús, García de Herreros, Antonio, Muñoz, Alberto
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/26203
Acceso en línea:http://hdl.handle.net/10230/26203
http://dx.doi.org/10.1155/2016/6213872
Access Level:acceso abierto
Palabra clave:Vitamina D
Cèl·lules epitelials -- Aspectes genètics
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spelling Vitamin D and the epithelial to mesenchymal transitionLarriba, María JesúsGarcía de Herreros, AntonioMuñoz, AlbertoVitamina DCèl·lules epitelials -- Aspectes genèticsSeveral studies support reciprocal regulation between the active vitamin D derivative 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) and the epithelial to mesenchymal transition (EMT). Thus, 1,25(OH)2D3 inhibits EMT via the induction of a variety of target genes that encode cell adhesion and polarity proteins responsible for the epithelial phenotype and through the repression of key EMT inducers. Both direct and indirect regulatory mechanisms mediate these effects. Conversely, certain master EMT inducers inhibit 1,25(OH)2D3 action by repressing the transcription of VDR gene encoding the high affinity vitamin D receptor that mediates 1,25(OH)2D3 effects. Consequently, the balance between the strength of 1,25(OH)2D3 signaling and the induction of EMT defines the cellular phenotype in each context. Here we review the current understanding of the genes and mechanisms involved in the interplay between 1,25(OH)2D3 and EMT.The work in the authors’ laboratories is supported by Ministerio de Econom´ıa y Competitividad of Spain-Fondo Europeo de Desarrollo Regional (FEDER) to Alberto Munoz (SAF2013- ˜ 43468-R), Instituto de Salud Carlos III-FEDER to Alberto Munoz (RD12/0036/0021) and Antonio García de Herreros (RD12/0036/0005), and Comunidad de Madrid to Alberto Muñoz and Antonio García de Herreros (S2010/BMD-2344 Colomics2).Hindawi Publishing Corporation201620162016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/26203http://dx.doi.org/10.1155/2016/6213872reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésStem Cells International. 2016;2016:6213872info:eu-repo/grantAgreement/ES/1PE/SAF2013-43468-RCopyright © 2016 María Jesús Larriba et al. This is an open access article distributed under the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/262032026-05-29T05:05:01Z
dc.title.none.fl_str_mv Vitamin D and the epithelial to mesenchymal transition
title Vitamin D and the epithelial to mesenchymal transition
spellingShingle Vitamin D and the epithelial to mesenchymal transition
Larriba, María Jesús
Vitamina D
Cèl·lules epitelials -- Aspectes genètics
title_short Vitamin D and the epithelial to mesenchymal transition
title_full Vitamin D and the epithelial to mesenchymal transition
title_fullStr Vitamin D and the epithelial to mesenchymal transition
title_full_unstemmed Vitamin D and the epithelial to mesenchymal transition
title_sort Vitamin D and the epithelial to mesenchymal transition
dc.creator.none.fl_str_mv Larriba, María Jesús
García de Herreros, Antonio
Muñoz, Alberto
author Larriba, María Jesús
author_facet Larriba, María Jesús
García de Herreros, Antonio
Muñoz, Alberto
author_role author
author2 García de Herreros, Antonio
Muñoz, Alberto
author2_role author
author
dc.subject.none.fl_str_mv Vitamina D
Cèl·lules epitelials -- Aspectes genètics
topic Vitamina D
Cèl·lules epitelials -- Aspectes genètics
description Several studies support reciprocal regulation between the active vitamin D derivative 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) and the epithelial to mesenchymal transition (EMT). Thus, 1,25(OH)2D3 inhibits EMT via the induction of a variety of target genes that encode cell adhesion and polarity proteins responsible for the epithelial phenotype and through the repression of key EMT inducers. Both direct and indirect regulatory mechanisms mediate these effects. Conversely, certain master EMT inducers inhibit 1,25(OH)2D3 action by repressing the transcription of VDR gene encoding the high affinity vitamin D receptor that mediates 1,25(OH)2D3 effects. Consequently, the balance between the strength of 1,25(OH)2D3 signaling and the induction of EMT defines the cellular phenotype in each context. Here we review the current understanding of the genes and mechanisms involved in the interplay between 1,25(OH)2D3 and EMT.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/26203
http://dx.doi.org/10.1155/2016/6213872
url http://hdl.handle.net/10230/26203
http://dx.doi.org/10.1155/2016/6213872
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Stem Cells International. 2016;2016:6213872
info:eu-repo/grantAgreement/ES/1PE/SAF2013-43468-R
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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