Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study.

10 páginas.

Detalles Bibliográficos
Autores: Pozo Rubio, Tamara, Capilla, Amalia, Mujico, Jorge R., Palma, Giada de, Marcos, Ascensión, Sanz Herranz, Yolanda, Nova, Esther
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/75575
Acceso en línea:http://hdl.handle.net/10261/75575
Access Level:acceso abierto
Palabra clave:Lymphocyte subsets
Celiac disease
Infants
HLA genotype
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spelling Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study.Pozo Rubio, TamaraCapilla, AmaliaMujico, Jorge R.Palma, Giada deMarcos, AscensiónSanz Herranz, YolandaNova, EstherLymphocyte subsetsCeliac diseaseInfantsHLA genotype10 páginas.Purpose: In addition to genetic risk, environmental factors might influence celiac disease (CD) development. We sought to assess the effect of the interaction between milk-feeding practices and the HLA-DQ genotype, on peripheral lymphocyte subsets and their activation markers in infants at familial risk for CD. Methods: 170 newborns were classified in 3 different genetic risk groups (high risk, HR; intermediate risk, IR; and low risk, LR) after DQB1 and DQA1 typing. Lymphocyte subsets were studied at the age of 4 months by flow cytometry analysis. Results: 79 infants were receiving exclusive breast-feeding (BF), and 91 partial breast-feeding or formula-feeding (FF). Regarding genetic risk, 40 infants were classified in HR group, 75 in IR group and 55 in LR group. Two-way ANOVA did not show significant interactions between the type of milkfeeding and genetic risk group on the lymphocyte subsets analysed. One-way ANOVA for milk-feeding practice alone showed that the percentage of CD4+CD25+ cells was significantly higher in BF group than in FF group (BF, 10.92±2.71; FF, 9.94±2.96; p=0.026), and absolute counts of CD4+CD38+ cells were significantly higher in FF group than in BF group (FF, 2881.23±973.48; BF, 2557.95±977.06; p=0.038). One-way ANOVA for genetic risk alone showed that absolute counts of NK cells were significantly higher in IR group than HR and LR groups (IR, 539.24±340.63; HR, 405.01±239.53; LR, 419.86±262.85; p=0.028). Conclusion: Lymphocyte subset profiles in the early stages of life could be modulated by milk-feeding practices and genetic risk separately. Breast-feeding might have a positive immunomodulatory effect on lymphocyte subsets in infants at risk for CD.supported by grants AGL2007-66126-C03-01/ALI, AGL2007-66126-C03-02/ALI and AGL2007-66126-C03-03/ALI, from the Spanish Ministry of Science and Innovation and grants 200570F0091 and 200570F0093 from CSIC.Peer reviewedSpringer Nature201320132013info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/75575reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglésinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/755752026-05-22T06:33:51Z
dc.title.none.fl_str_mv Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study.
title Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study.
spellingShingle Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study.
Pozo Rubio, Tamara
Lymphocyte subsets
Celiac disease
Infants
HLA genotype
title_short Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study.
title_full Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study.
title_fullStr Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study.
title_full_unstemmed Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study.
title_sort Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study.
dc.creator.none.fl_str_mv Pozo Rubio, Tamara
Capilla, Amalia
Mujico, Jorge R.
Palma, Giada de
Marcos, Ascensión
Sanz Herranz, Yolanda
Nova, Esther
author Pozo Rubio, Tamara
author_facet Pozo Rubio, Tamara
Capilla, Amalia
Mujico, Jorge R.
Palma, Giada de
Marcos, Ascensión
Sanz Herranz, Yolanda
Nova, Esther
author_role author
author2 Capilla, Amalia
Mujico, Jorge R.
Palma, Giada de
Marcos, Ascensión
Sanz Herranz, Yolanda
Nova, Esther
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Lymphocyte subsets
Celiac disease
Infants
HLA genotype
topic Lymphocyte subsets
Celiac disease
Infants
HLA genotype
description 10 páginas.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013
2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/75575
url http://hdl.handle.net/10261/75575
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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