A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes

29 páginas, 5 figuras, 2 tablas.

Detalhes bibliográficos
Autores: Spyrou, Giannis, Wilson, William, Padilla, Alicia C., Holmgren, Arne, Miranda-Vizuete, Antonio
Formato: artículo
Fecha de publicación:2001
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/47435
Acesso em linha:http://hdl.handle.net/10261/47435
Access Level:acceso abierto
Palavra-chave:Chromosomes
Genome
Glutaredoxin
Oxidoreductases
Phylogeny
Protein
Pseudogene
Sequence alignment
Thioredoxin
Retrotransposition
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spelling A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenesSpyrou, GiannisWilson, WilliamPadilla, Alicia C.Holmgren, ArneMiranda-Vizuete, AntonioChromosomesGenomeGlutaredoxinOxidoreductasesPhylogenyProteinPseudogeneSequence alignmentThioredoxinRetrotransposition29 páginas, 5 figuras, 2 tablas.The thioredoxin/glutaredoxin family consists of small heat-stable proteins that have a highly conserved CXXC active site and that participate in the regulation of many redox reactions. We have searched the human genome sequence to find putative pseudogenes (non-functional copies of protein-coding genes) for all known members of this family. This survey has resulted in the identification of seven processed pseudogenes for human Trx1 and two more for human Grx1. No evidence for the presence of processed pseudogenes has been found for the remaining members of this family. In addition, we have been unable to detect any non-processed pseudogenes derived from any member of the family in the human genome. The seven thioredoxin pseudogenes can be divided into two groups: Trx1-N2, -N3, -N4, -N5 and -N6 arose from the functional ancestor, whereas Trx1-N1 and -N7 originated from Trx1-N2 and -N6, respectively. In all cases, the pseudogenes originated after the human/rodent radiation as shown by phylogenetic analysis. This is also the case for Grx1-N1 and Grx1-N2, which are placed between rodent and human sequences in the phylogenetic tree. Our study provides a molecular record of the recent evolution of these two genes in the hominid lineage.This work was supported by grants from the Swedish Medical Research Council (Projects 03P-14096-01A, 03X-14041-01A and 13X-10370), the Swedish Cancer Society (961) and the Karolinska Institute.Peer reviewedSpringer Nature201220122001info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/47435reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1007/s004390100597info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/474352026-05-22T06:33:51Z
dc.title.none.fl_str_mv A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes
title A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes
spellingShingle A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes
Spyrou, Giannis
Chromosomes
Genome
Glutaredoxin
Oxidoreductases
Phylogeny
Protein
Pseudogene
Sequence alignment
Thioredoxin
Retrotransposition
title_short A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes
title_full A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes
title_fullStr A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes
title_full_unstemmed A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes
title_sort A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes
dc.creator.none.fl_str_mv Spyrou, Giannis
Wilson, William
Padilla, Alicia C.
Holmgren, Arne
Miranda-Vizuete, Antonio
author Spyrou, Giannis
author_facet Spyrou, Giannis
Wilson, William
Padilla, Alicia C.
Holmgren, Arne
Miranda-Vizuete, Antonio
author_role author
author2 Wilson, William
Padilla, Alicia C.
Holmgren, Arne
Miranda-Vizuete, Antonio
author2_role author
author
author
author
dc.subject.none.fl_str_mv Chromosomes
Genome
Glutaredoxin
Oxidoreductases
Phylogeny
Protein
Pseudogene
Sequence alignment
Thioredoxin
Retrotransposition
topic Chromosomes
Genome
Glutaredoxin
Oxidoreductases
Phylogeny
Protein
Pseudogene
Sequence alignment
Thioredoxin
Retrotransposition
description 29 páginas, 5 figuras, 2 tablas.
publishDate 2001
dc.date.none.fl_str_mv 2001
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/47435
url http://hdl.handle.net/10261/47435
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1007/s004390100597
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406911459229696
score 15.198674

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