Spatial IMA1 regulation restricts root iron acquisition on MAMP perception

Iron is critical during host-microorganism interactions. Restriction of available iron by the host during infection is an important defence strategy, described as nutritional immunity. However, this poses a conundrum for externally facing, absorptive tissues such as the gut epithelium or the plant r...

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Autores: Cao, Min, Platre, Matthieu Pierre|||0000-0002-4934-3050, Tsai, Huei-Hsuan|||0000-0002-5166-2181, Zhang, Ling, Nobori, Tatsuya, Armengot, Laia|||0000-0002-3790-9838, Chen, Yintong|||0000-0002-2219-3136, He, Wenrong, Brent, Lukas|||0000-0002-8292-368X, Sánchez Coll, Núria|||0000-0002-8889-0399, Ecker, Joseph R., Geldner, Niko|||0000-0002-2300-9644, Busch, Wolfgang|||0000-0003-2042-7290
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:312862
Acceso en línea:https://ddd.uab.cat/record/312862
https://dx.doi.org/urn:doi:10.1038/s41586-023-06891-y
Access Level:acceso abierto
Palabra clave:Arabidopsis
Arabidopsis Proteins
Bacteria
Gene Expression Regulation
Humans
Perception
Plant Roots
Rhizosphere
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spelling Spatial IMA1 regulation restricts root iron acquisition on MAMP perceptionCao, MinPlatre, Matthieu Pierre|||0000-0002-4934-3050Tsai, Huei-Hsuan|||0000-0002-5166-2181Zhang, LingNobori, TatsuyaArmengot, Laia|||0000-0002-3790-9838Chen, Yintong|||0000-0002-2219-3136He, WenrongBrent, Lukas|||0000-0002-8292-368XSánchez Coll, Núria|||0000-0002-8889-0399Ecker, Joseph R.Geldner, Niko|||0000-0002-2300-9644Busch, Wolfgang|||0000-0003-2042-7290ArabidopsisArabidopsis ProteinsBacteriaGene Expression RegulationHumansPerceptionPlant RootsRhizosphereIron is critical during host-microorganism interactions. Restriction of available iron by the host during infection is an important defence strategy, described as nutritional immunity. However, this poses a conundrum for externally facing, absorptive tissues such as the gut epithelium or the plant root epidermis that generate environments that favour iron bioavailability. For example, plant roots acquire iron mostly from the soil and, when iron deficient, increase iron availability through mechanisms that include rhizosphere acidification and secretion of iron chelators. Yet, the elevated iron bioavailability would also be beneficial for the growth of bacteria that threaten plant health. Here we report that microorganism-associated molecular patterns such as flagellin lead to suppression of root iron acquisition through a localized degradation of the systemic iron-deficiency signalling peptide Iron Man 1 (IMA1) in Arabidopsis thaliana. This response is also elicited when bacteria enter root tissues, but not when they dwell on the outer root surface. IMA1 itself has a role in modulating immunity in root and shoot, affecting the levels of root colonization and the resistance to a bacterial foliar pathogen. Our findings reveal an adaptive molecular mechanism of nutritional immunity that affects iron bioavailability and uptake, as well as immune responses. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/312862https://dx.doi.org/urn:doi:10.1038/s41586-023-06891-yreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-108595RB-I00Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 TED2021-131457B-I00Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 CEX2019-000917open accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3128622026-06-06T12:50:31Z
dc.title.none.fl_str_mv Spatial IMA1 regulation restricts root iron acquisition on MAMP perception
title Spatial IMA1 regulation restricts root iron acquisition on MAMP perception
spellingShingle Spatial IMA1 regulation restricts root iron acquisition on MAMP perception
Cao, Min
Arabidopsis
Arabidopsis Proteins
Bacteria
Gene Expression Regulation
Humans
Perception
Plant Roots
Rhizosphere
title_short Spatial IMA1 regulation restricts root iron acquisition on MAMP perception
title_full Spatial IMA1 regulation restricts root iron acquisition on MAMP perception
title_fullStr Spatial IMA1 regulation restricts root iron acquisition on MAMP perception
title_full_unstemmed Spatial IMA1 regulation restricts root iron acquisition on MAMP perception
title_sort Spatial IMA1 regulation restricts root iron acquisition on MAMP perception
dc.creator.none.fl_str_mv Cao, Min
Platre, Matthieu Pierre|||0000-0002-4934-3050
Tsai, Huei-Hsuan|||0000-0002-5166-2181
Zhang, Ling
Nobori, Tatsuya
Armengot, Laia|||0000-0002-3790-9838
Chen, Yintong|||0000-0002-2219-3136
He, Wenrong
Brent, Lukas|||0000-0002-8292-368X
Sánchez Coll, Núria|||0000-0002-8889-0399
Ecker, Joseph R.
Geldner, Niko|||0000-0002-2300-9644
Busch, Wolfgang|||0000-0003-2042-7290
author Cao, Min
author_facet Cao, Min
Platre, Matthieu Pierre|||0000-0002-4934-3050
Tsai, Huei-Hsuan|||0000-0002-5166-2181
Zhang, Ling
Nobori, Tatsuya
Armengot, Laia|||0000-0002-3790-9838
Chen, Yintong|||0000-0002-2219-3136
He, Wenrong
Brent, Lukas|||0000-0002-8292-368X
Sánchez Coll, Núria|||0000-0002-8889-0399
Ecker, Joseph R.
Geldner, Niko|||0000-0002-2300-9644
Busch, Wolfgang|||0000-0003-2042-7290
author_role author
author2 Platre, Matthieu Pierre|||0000-0002-4934-3050
Tsai, Huei-Hsuan|||0000-0002-5166-2181
Zhang, Ling
Nobori, Tatsuya
Armengot, Laia|||0000-0002-3790-9838
Chen, Yintong|||0000-0002-2219-3136
He, Wenrong
Brent, Lukas|||0000-0002-8292-368X
Sánchez Coll, Núria|||0000-0002-8889-0399
Ecker, Joseph R.
Geldner, Niko|||0000-0002-2300-9644
Busch, Wolfgang|||0000-0003-2042-7290
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Arabidopsis
Arabidopsis Proteins
Bacteria
Gene Expression Regulation
Humans
Perception
Plant Roots
Rhizosphere
topic Arabidopsis
Arabidopsis Proteins
Bacteria
Gene Expression Regulation
Humans
Perception
Plant Roots
Rhizosphere
description Iron is critical during host-microorganism interactions. Restriction of available iron by the host during infection is an important defence strategy, described as nutritional immunity. However, this poses a conundrum for externally facing, absorptive tissues such as the gut epithelium or the plant root epidermis that generate environments that favour iron bioavailability. For example, plant roots acquire iron mostly from the soil and, when iron deficient, increase iron availability through mechanisms that include rhizosphere acidification and secretion of iron chelators. Yet, the elevated iron bioavailability would also be beneficial for the growth of bacteria that threaten plant health. Here we report that microorganism-associated molecular patterns such as flagellin lead to suppression of root iron acquisition through a localized degradation of the systemic iron-deficiency signalling peptide Iron Man 1 (IMA1) in Arabidopsis thaliana. This response is also elicited when bacteria enter root tissues, but not when they dwell on the outer root surface. IMA1 itself has a role in modulating immunity in root and shoot, affecting the levels of root colonization and the resistance to a bacterial foliar pathogen. Our findings reveal an adaptive molecular mechanism of nutritional immunity that affects iron bioavailability and uptake, as well as immune responses.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/312862
https://dx.doi.org/urn:doi:10.1038/s41586-023-06891-y
url https://ddd.uab.cat/record/312862
https://dx.doi.org/urn:doi:10.1038/s41586-023-06891-y
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-108595RB-I00
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 TED2021-131457B-I00
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 CEX2019-000917
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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repository.mail.fl_str_mv
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