Hydrogen-rich water as a novel therapeutic strategy for the affective disorders linked with chronic neuropathic pain in mice

Neuropathic pain manifested with allodynia and hyperalgesia usually becomes a chronic condition accompanied with mood disorders. Clinical therapies for neuropathic pain are still unsatisfactory with notable side effects. Recent studies have reported the protective role of molecular hydrogen (H) in d...

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Autores: Martínez-Serrat, Maria, Martínez-Martel, Ignacio|||0009-0006-3100-8293, Coral-Pérez, Santiago, Bai, Xue|||0000-0002-7283-3189, Batallé Melgarejo, Gerard|||0000-0003-2065-2914, Pol, Olga|||0000-0002-4621-8457
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:266248
Acceso en línea:https://ddd.uab.cat/record/266248
https://dx.doi.org/urn:doi:10.3390/antiox11091826
Access Level:acceso abierto
Palabra clave:Analgesia
Apoptosis
Hydrogen-rich water
Inflammation
Molecular hydrogen
Neuropathic pain
Oxidative stress
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spelling Hydrogen-rich water as a novel therapeutic strategy for the affective disorders linked with chronic neuropathic pain in miceMartínez-Serrat, MariaMartínez-Martel, Ignacio|||0009-0006-3100-8293Coral-Pérez, SantiagoBai, Xue|||0000-0002-7283-3189Batallé Melgarejo, Gerard|||0000-0003-2065-2914Pol, Olga|||0000-0002-4621-8457AnalgesiaApoptosisHydrogen-rich waterInflammationMolecular hydrogenNeuropathic painOxidative stressNeuropathic pain manifested with allodynia and hyperalgesia usually becomes a chronic condition accompanied with mood disorders. Clinical therapies for neuropathic pain are still unsatisfactory with notable side effects. Recent studies have reported the protective role of molecular hydrogen (H) in different diseases including neurological disorders, such as Alzheimer's as well as its antidepressant activities in animals with chronic stress. This study explored the effects of treatment with hydrogen-rich water (HRW) in male mice with neuropathic pain induced by the chronic constriction of the sciatic nerve (CCI) and the accompanying affective deficits. The likely pathways implied in the HRW analgesic activity, as well as the interaction between heme oxygenase 1 (HO-1) enzyme and H during neuropathic pain were also studied. The results showed: (i) the inhibitory effects of the repetitive treatment with HRW on the allodynia and hyperalgesia provoked by CCI; (ii) the anxiolytic and antidepressant actions of HRW in animals with neuropathic pain; (iii) the contribution of the antioxidant enzymes (HO-1 and NAD(P)H: quinone oxidoreductase 1) and the ATP sensitive potassium channels in the painkiller activities of HRW during neuropathic pain; (iv) a positive interaction between the HO-1 and H systems in inhibiting the CCI-induced neuropathy; and (v) the antioxidant, antinociceptive, anti-inflammatory and/or antiapoptotic features of HRW treatment in the dorsal root ganglia and/or amygdala of sciatic nerve-injured mice. This study demonstrates new protective actions of H and suggests that treatment with HRW might be an interesting therapeutic strategy for chronic neuropathic pain and its associated mood disorders.Institut de Recerca Sant Pau 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/266248https://dx.doi.org/urn:doi:10.3390/antiox11091826reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00645Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI21/00592open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2662482026-06-06T12:50:31Z
dc.title.none.fl_str_mv Hydrogen-rich water as a novel therapeutic strategy for the affective disorders linked with chronic neuropathic pain in mice
title Hydrogen-rich water as a novel therapeutic strategy for the affective disorders linked with chronic neuropathic pain in mice
spellingShingle Hydrogen-rich water as a novel therapeutic strategy for the affective disorders linked with chronic neuropathic pain in mice
Martínez-Serrat, Maria
Analgesia
Apoptosis
Hydrogen-rich water
Inflammation
Molecular hydrogen
Neuropathic pain
Oxidative stress
title_short Hydrogen-rich water as a novel therapeutic strategy for the affective disorders linked with chronic neuropathic pain in mice
title_full Hydrogen-rich water as a novel therapeutic strategy for the affective disorders linked with chronic neuropathic pain in mice
title_fullStr Hydrogen-rich water as a novel therapeutic strategy for the affective disorders linked with chronic neuropathic pain in mice
title_full_unstemmed Hydrogen-rich water as a novel therapeutic strategy for the affective disorders linked with chronic neuropathic pain in mice
title_sort Hydrogen-rich water as a novel therapeutic strategy for the affective disorders linked with chronic neuropathic pain in mice
dc.creator.none.fl_str_mv Martínez-Serrat, Maria
Martínez-Martel, Ignacio|||0009-0006-3100-8293
Coral-Pérez, Santiago
Bai, Xue|||0000-0002-7283-3189
Batallé Melgarejo, Gerard|||0000-0003-2065-2914
Pol, Olga|||0000-0002-4621-8457
author Martínez-Serrat, Maria
author_facet Martínez-Serrat, Maria
Martínez-Martel, Ignacio|||0009-0006-3100-8293
Coral-Pérez, Santiago
Bai, Xue|||0000-0002-7283-3189
Batallé Melgarejo, Gerard|||0000-0003-2065-2914
Pol, Olga|||0000-0002-4621-8457
author_role author
author2 Martínez-Martel, Ignacio|||0009-0006-3100-8293
Coral-Pérez, Santiago
Bai, Xue|||0000-0002-7283-3189
Batallé Melgarejo, Gerard|||0000-0003-2065-2914
Pol, Olga|||0000-0002-4621-8457
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Institut de Recerca Sant Pau
dc.subject.none.fl_str_mv Analgesia
Apoptosis
Hydrogen-rich water
Inflammation
Molecular hydrogen
Neuropathic pain
Oxidative stress
topic Analgesia
Apoptosis
Hydrogen-rich water
Inflammation
Molecular hydrogen
Neuropathic pain
Oxidative stress
description Neuropathic pain manifested with allodynia and hyperalgesia usually becomes a chronic condition accompanied with mood disorders. Clinical therapies for neuropathic pain are still unsatisfactory with notable side effects. Recent studies have reported the protective role of molecular hydrogen (H) in different diseases including neurological disorders, such as Alzheimer's as well as its antidepressant activities in animals with chronic stress. This study explored the effects of treatment with hydrogen-rich water (HRW) in male mice with neuropathic pain induced by the chronic constriction of the sciatic nerve (CCI) and the accompanying affective deficits. The likely pathways implied in the HRW analgesic activity, as well as the interaction between heme oxygenase 1 (HO-1) enzyme and H during neuropathic pain were also studied. The results showed: (i) the inhibitory effects of the repetitive treatment with HRW on the allodynia and hyperalgesia provoked by CCI; (ii) the anxiolytic and antidepressant actions of HRW in animals with neuropathic pain; (iii) the contribution of the antioxidant enzymes (HO-1 and NAD(P)H: quinone oxidoreductase 1) and the ATP sensitive potassium channels in the painkiller activities of HRW during neuropathic pain; (iv) a positive interaction between the HO-1 and H systems in inhibiting the CCI-induced neuropathy; and (v) the antioxidant, antinociceptive, anti-inflammatory and/or antiapoptotic features of HRW treatment in the dorsal root ganglia and/or amygdala of sciatic nerve-injured mice. This study demonstrates new protective actions of H and suggests that treatment with HRW might be an interesting therapeutic strategy for chronic neuropathic pain and its associated mood disorders.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/266248
https://dx.doi.org/urn:doi:10.3390/antiox11091826
url https://ddd.uab.cat/record/266248
https://dx.doi.org/urn:doi:10.3390/antiox11091826
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00645
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI21/00592
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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