Regulation of replication fork advance and stability by nucleosome assembly

he advance of replication forks to duplicate chromosomes in dividing cells requires the disassembly of nucleosomes ahead of the fork and the rapid assembly of parental and de novo histones at the newly synthesized strands behind the fork. Replication-coupled chromatin assembly provides a unique oppo...

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Detalles Bibliográficos
Autores: Prado Velasco, José Félix, Maya, Douglas
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/64268
Acceso en línea:http://hdl.handle.net/11441/64268
https://doi.org/10.3390/genes8020049
Access Level:acceso abierto
Palabra clave:Chromatin assembly
DNA damage tolerance
DNA replication
Homologous recombination
Replication fork stability
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spelling Regulation of replication fork advance and stability by nucleosome assemblyPrado Velasco, José FélixMaya, DouglasChromatin assemblyDNA damage toleranceDNA replicationHomologous recombinationReplication fork stabilityhe advance of replication forks to duplicate chromosomes in dividing cells requires the disassembly of nucleosomes ahead of the fork and the rapid assembly of parental and de novo histones at the newly synthesized strands behind the fork. Replication-coupled chromatin assembly provides a unique opportunity to regulate fork advance and stability. Through post-translational histone modifications and tightly regulated physical and genetic interactions between chromatin assembly factors and replisome components, chromatin assembly: (1) controls the rate of DNA synthesis and adjusts it to histone availability; (2) provides a mechanism to protect the integrity of the advancing fork; and (3) regulates the mechanisms of DNA damage tolerance in response to replication-blocking lesions. Uncoupling DNA synthesis from nucleosome assembly has deleterious effects on genome integrity and cell cycle progression and is linked to genetic diseases, cancer, and aging.Multidisciplinary Digital Publishing Institute (MDPI)2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/11441/64268https://doi.org/10.3390/genes8020049reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésGenes, 8 (2), 49-.http://dx.doi.org/10.3390/genes8020049info:eu-repo/semantics/openAccessoai:idus.us.es:11441/642682026-06-17T12:51:07Z
dc.title.none.fl_str_mv Regulation of replication fork advance and stability by nucleosome assembly
title Regulation of replication fork advance and stability by nucleosome assembly
spellingShingle Regulation of replication fork advance and stability by nucleosome assembly
Prado Velasco, José Félix
Chromatin assembly
DNA damage tolerance
DNA replication
Homologous recombination
Replication fork stability
title_short Regulation of replication fork advance and stability by nucleosome assembly
title_full Regulation of replication fork advance and stability by nucleosome assembly
title_fullStr Regulation of replication fork advance and stability by nucleosome assembly
title_full_unstemmed Regulation of replication fork advance and stability by nucleosome assembly
title_sort Regulation of replication fork advance and stability by nucleosome assembly
dc.creator.none.fl_str_mv Prado Velasco, José Félix
Maya, Douglas
author Prado Velasco, José Félix
author_facet Prado Velasco, José Félix
Maya, Douglas
author_role author
author2 Maya, Douglas
author2_role author
dc.subject.none.fl_str_mv Chromatin assembly
DNA damage tolerance
DNA replication
Homologous recombination
Replication fork stability
topic Chromatin assembly
DNA damage tolerance
DNA replication
Homologous recombination
Replication fork stability
description he advance of replication forks to duplicate chromosomes in dividing cells requires the disassembly of nucleosomes ahead of the fork and the rapid assembly of parental and de novo histones at the newly synthesized strands behind the fork. Replication-coupled chromatin assembly provides a unique opportunity to regulate fork advance and stability. Through post-translational histone modifications and tightly regulated physical and genetic interactions between chromatin assembly factors and replisome components, chromatin assembly: (1) controls the rate of DNA synthesis and adjusts it to histone availability; (2) provides a mechanism to protect the integrity of the advancing fork; and (3) regulates the mechanisms of DNA damage tolerance in response to replication-blocking lesions. Uncoupling DNA synthesis from nucleosome assembly has deleterious effects on genome integrity and cell cycle progression and is linked to genetic diseases, cancer, and aging.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11441/64268
https://doi.org/10.3390/genes8020049
url http://hdl.handle.net/11441/64268
https://doi.org/10.3390/genes8020049
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Genes, 8 (2), 49-.
http://dx.doi.org/10.3390/genes8020049
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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