Inhibitory control failures and blunted cortisol response to psychosocial stress in amphetamine consumers after 6 months of abstinence

Amphetamine abuse has been conceived as an addictive illness where stress regulation and inhibitory control may be crucial factors determining chronicity and relapse. Since amphetamine consumption may disrupt the cerebral systems regulating inhibition and stress behaviors, deregulation on these syst...

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Autores: Benitez López, Yermein, Redolar-Ripoll, Diego Emilia, Ruvalcaba Delgadillo, Yaveth, Jáuregui Huerta, Fernando
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universitat Oberta de Catalunya (UOC)
Repositorio:O2, repositorio institucional de la UOC
OAI Identifier:oai:openaccess.uoc.edu:10609/89326
Acceso en línea:http://hdl.handle.net/10609/89326
Access Level:acceso abierto
Palabra clave:abstinence
stress
executive functions
cortisol
amphetamine
abstinencia
estrés
funciones ejecutivas
anfetamina
abstinència
estrès
funcions executives
amfetamina
Drug control
Drogues -- Control
Drogas -- Control
id ES_41cd570b83e77ec23b1cb2dd2df4631c
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repository_id_str
spelling Inhibitory control failures and blunted cortisol response to psychosocial stress in amphetamine consumers after 6 months of abstinenceBenitez López, YermeinRedolar-Ripoll, Diego EmiliaRuvalcaba Delgadillo, YavethJáuregui Huerta, Fernandoabstinencestressexecutive functionscortisolamphetaminecortisolabstinenciaestrésfunciones ejecutivascortisolanfetaminaabstinènciaestrèsfuncions executivescortisolamfetaminaDrug controlDrogues -- ControlDrogas -- ControlAmphetamine abuse has been conceived as an addictive illness where stress regulation and inhibitory control may be crucial factors determining chronicity and relapse. Since amphetamine consumption may disrupt the cerebral systems regulating inhibition and stress behaviors, deregulation on these systems may be expected even after long-term abstinence periods. The present study aimed to evaluate the ability of abstinent amphetamine consumers to regulate stress parameters and to inhibit cognitive patterns under the acute trier social stress test (TSST) paradigm. Materials and Methods, a cohort study was conducted in a sample of 44 young individuals (average age: 24.6 years). The sample included 22 amphetamine consumers recruited from an addiction treatment center and 22 healthy nonconsumers belonging to the same sociodemographic conditions. Both groups were exposed to the TSST once the consumers completed 6 months in abstinence. To evaluate stress reactivity, we collected five saliva samples distributed before, during, and after stress exposure. Inhibitory capacity was also assessed before and after stress using the Stroop and d2 cancellation tests. Results, under stress conditions, cortisol measures were significantly lower in amphetamine consumers (1105.34 ± 756.958) than in healthy nonconsumers (1771.86 ± 1174.248) P = 0.022. Without stress, amphetamine consumers also showed lower cortisol values (1027.61 ± 709.8) than nonconsumers (1844.21 ± 1099.15) P = 0.016. Regarding inhibitory capacity, stress also was associated to consumer's lower scores on the Stroop (5.17 ± 8.34 vs. 10.58 ± 7.83) P = 0.032 and d2 tests (190.27 ± 29.47 vs. 218.00 ± 38.08) P = 0.010. Conclusion: We concluded that both the stress regulatory system and executive function system (attentional/inhibitory control) represent key vulnerability conditions to the long-term effect of compulsive amphetamine consumption.Journal of Research in Medical SciencesUniversidad de GuadalajaraUniversitat Oberta de Catalunya. Estudis de Ciències de la Salut201920192018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10609/89326reponame:O2, repositorio institucional de la UOCinstname:Universitat Oberta de Catalunya (UOC)Inglésinfo:eu-repo/grantAgreement/CONACyT238313//info:eu-repo/grantAgreement/CONACyT221092//info:eu-repo/grantAgreement/PROMEP NPTC236855//CC BY-NC-SAhttps://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:openaccess.uoc.edu:10609/893262026-05-28T12:42:01Z
dc.title.none.fl_str_mv Inhibitory control failures and blunted cortisol response to psychosocial stress in amphetamine consumers after 6 months of abstinence
title Inhibitory control failures and blunted cortisol response to psychosocial stress in amphetamine consumers after 6 months of abstinence
spellingShingle Inhibitory control failures and blunted cortisol response to psychosocial stress in amphetamine consumers after 6 months of abstinence
Benitez López, Yermein
abstinence
stress
executive functions
cortisol
amphetamine
cortisol
abstinencia
estrés
funciones ejecutivas
cortisol
anfetamina
abstinència
estrès
funcions executives
cortisol
amfetamina
Drug control
Drogues -- Control
Drogas -- Control
title_short Inhibitory control failures and blunted cortisol response to psychosocial stress in amphetamine consumers after 6 months of abstinence
title_full Inhibitory control failures and blunted cortisol response to psychosocial stress in amphetamine consumers after 6 months of abstinence
title_fullStr Inhibitory control failures and blunted cortisol response to psychosocial stress in amphetamine consumers after 6 months of abstinence
title_full_unstemmed Inhibitory control failures and blunted cortisol response to psychosocial stress in amphetamine consumers after 6 months of abstinence
title_sort Inhibitory control failures and blunted cortisol response to psychosocial stress in amphetamine consumers after 6 months of abstinence
dc.creator.none.fl_str_mv Benitez López, Yermein
Redolar-Ripoll, Diego Emilia
Ruvalcaba Delgadillo, Yaveth
Jáuregui Huerta, Fernando
author Benitez López, Yermein
author_facet Benitez López, Yermein
Redolar-Ripoll, Diego Emilia
Ruvalcaba Delgadillo, Yaveth
Jáuregui Huerta, Fernando
author_role author
author2 Redolar-Ripoll, Diego Emilia
Ruvalcaba Delgadillo, Yaveth
Jáuregui Huerta, Fernando
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad de Guadalajara
Universitat Oberta de Catalunya. Estudis de Ciències de la Salut
dc.subject.none.fl_str_mv abstinence
stress
executive functions
cortisol
amphetamine
cortisol
abstinencia
estrés
funciones ejecutivas
cortisol
anfetamina
abstinència
estrès
funcions executives
cortisol
amfetamina
Drug control
Drogues -- Control
Drogas -- Control
topic abstinence
stress
executive functions
cortisol
amphetamine
cortisol
abstinencia
estrés
funciones ejecutivas
cortisol
anfetamina
abstinència
estrès
funcions executives
cortisol
amfetamina
Drug control
Drogues -- Control
Drogas -- Control
description Amphetamine abuse has been conceived as an addictive illness where stress regulation and inhibitory control may be crucial factors determining chronicity and relapse. Since amphetamine consumption may disrupt the cerebral systems regulating inhibition and stress behaviors, deregulation on these systems may be expected even after long-term abstinence periods. The present study aimed to evaluate the ability of abstinent amphetamine consumers to regulate stress parameters and to inhibit cognitive patterns under the acute trier social stress test (TSST) paradigm. Materials and Methods, a cohort study was conducted in a sample of 44 young individuals (average age: 24.6 years). The sample included 22 amphetamine consumers recruited from an addiction treatment center and 22 healthy nonconsumers belonging to the same sociodemographic conditions. Both groups were exposed to the TSST once the consumers completed 6 months in abstinence. To evaluate stress reactivity, we collected five saliva samples distributed before, during, and after stress exposure. Inhibitory capacity was also assessed before and after stress using the Stroop and d2 cancellation tests. Results, under stress conditions, cortisol measures were significantly lower in amphetamine consumers (1105.34 ± 756.958) than in healthy nonconsumers (1771.86 ± 1174.248) P = 0.022. Without stress, amphetamine consumers also showed lower cortisol values (1027.61 ± 709.8) than nonconsumers (1844.21 ± 1099.15) P = 0.016. Regarding inhibitory capacity, stress also was associated to consumer's lower scores on the Stroop (5.17 ± 8.34 vs. 10.58 ± 7.83) P = 0.032 and d2 tests (190.27 ± 29.47 vs. 218.00 ± 38.08) P = 0.010. Conclusion: We concluded that both the stress regulatory system and executive function system (attentional/inhibitory control) represent key vulnerability conditions to the long-term effect of compulsive amphetamine consumption.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10609/89326
url http://hdl.handle.net/10609/89326
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/CONACyT238313//
info:eu-repo/grantAgreement/CONACyT221092//
info:eu-repo/grantAgreement/PROMEP NPTC236855//
dc.rights.none.fl_str_mv CC BY-NC-SA
https://creativecommons.org/licenses/by-nc-sa/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv CC BY-NC-SA
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Journal of Research in Medical Sciences
publisher.none.fl_str_mv Journal of Research in Medical Sciences
dc.source.none.fl_str_mv reponame:O2, repositorio institucional de la UOC
instname:Universitat Oberta de Catalunya (UOC)
instname_str Universitat Oberta de Catalunya (UOC)
reponame_str O2, repositorio institucional de la UOC
collection O2, repositorio institucional de la UOC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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