Predation risk determines pigmentation phenotype in nuthatches by melanin-related gene expression effects

Pigments determine the appearance of organisms. However, pigment production can be associated with physiological constraints as in the case of pheomelanin, the sulphurated form of melanin whose synthesis in melanocytes consumes cysteine and consequently reduces the availability of glutathione (GSH)...

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Detalhes bibliográficos
Autor: Galván, Ismael
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/201826
Acesso em linha:http://hdl.handle.net/10261/201826
Access Level:acceso abierto
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repository_id_str
spelling Predation risk determines pigmentation phenotype in nuthatches by melanin-related gene expression effectsGalván, IsmaelPigments determine the appearance of organisms. However, pigment production can be associated with physiological constraints as in the case of pheomelanin, the sulphurated form of melanin whose synthesis in melanocytes consumes cysteine and consequently reduces the availability of glutathione (GSH) to exert antioxidant protection. Pheomelanogenesis may thus increase the susceptibility to suffer chronic oxidative stress. I investigated the possibility that environmental lability in the expression of genes regulating pheomelanogenesis protects from oxidative stress, a situation in which GSH is most required. By broadcasting adult alarm calls, I manipulated the perception of predation risk, a natural source of oxidative stress, in free-living Eurasian nuthatch Sitta europaea nestlings developing pheomelanin-pigmented flank feathers. The manipulation affected the consumption of GSH that resulted from the expression of two genes (Slc7a11 and Slc45a2) influencing cysteine/GSH availability in cells, as these genes were down-regulated in the feather melanocytes of the nestlings with lowest intracellular antioxidant capacity (i.e. lowest GSH levels). Systemic oxidative damage increased with Slc7a11 expression in feather melanocytes, suggesting that the observed down-regulation was physiologically advantageous. The nestlings exposed to an increased perception of predation risk developed flank feathers of reduced colour intensity. These results indicate that perceived predation risk can determine the pigmentation phenotype by (probably epigenetic) effects on gene expression that protect from physiological constraints imposed by pheomelanin production.Peer reviewedBlackwell PublishingConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020182020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/201826reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésGalván, Ismael (2018): Data from: Predation risk determines pigmentation phenotype in nuthatches by melanin-related gene expression effects [Dataset]; Dryad; Version 1; https://doi.org/10.5061/dryad.6rb12hkhttp://dx.doi.org/10.1111/jeb.13379Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2018262026-05-22T06:33:51Z
dc.title.none.fl_str_mv Predation risk determines pigmentation phenotype in nuthatches by melanin-related gene expression effects
title Predation risk determines pigmentation phenotype in nuthatches by melanin-related gene expression effects
spellingShingle Predation risk determines pigmentation phenotype in nuthatches by melanin-related gene expression effects
Galván, Ismael
title_short Predation risk determines pigmentation phenotype in nuthatches by melanin-related gene expression effects
title_full Predation risk determines pigmentation phenotype in nuthatches by melanin-related gene expression effects
title_fullStr Predation risk determines pigmentation phenotype in nuthatches by melanin-related gene expression effects
title_full_unstemmed Predation risk determines pigmentation phenotype in nuthatches by melanin-related gene expression effects
title_sort Predation risk determines pigmentation phenotype in nuthatches by melanin-related gene expression effects
dc.creator.none.fl_str_mv Galván, Ismael
author Galván, Ismael
author_facet Galván, Ismael
author_role author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description Pigments determine the appearance of organisms. However, pigment production can be associated with physiological constraints as in the case of pheomelanin, the sulphurated form of melanin whose synthesis in melanocytes consumes cysteine and consequently reduces the availability of glutathione (GSH) to exert antioxidant protection. Pheomelanogenesis may thus increase the susceptibility to suffer chronic oxidative stress. I investigated the possibility that environmental lability in the expression of genes regulating pheomelanogenesis protects from oxidative stress, a situation in which GSH is most required. By broadcasting adult alarm calls, I manipulated the perception of predation risk, a natural source of oxidative stress, in free-living Eurasian nuthatch Sitta europaea nestlings developing pheomelanin-pigmented flank feathers. The manipulation affected the consumption of GSH that resulted from the expression of two genes (Slc7a11 and Slc45a2) influencing cysteine/GSH availability in cells, as these genes were down-regulated in the feather melanocytes of the nestlings with lowest intracellular antioxidant capacity (i.e. lowest GSH levels). Systemic oxidative damage increased with Slc7a11 expression in feather melanocytes, suggesting that the observed down-regulation was physiologically advantageous. The nestlings exposed to an increased perception of predation risk developed flank feathers of reduced colour intensity. These results indicate that perceived predation risk can determine the pigmentation phenotype by (probably epigenetic) effects on gene expression that protect from physiological constraints imposed by pheomelanin production.
publishDate 2018
dc.date.none.fl_str_mv 2018
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/201826
url http://hdl.handle.net/10261/201826
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Galván, Ismael (2018): Data from: Predation risk determines pigmentation phenotype in nuthatches by melanin-related gene expression effects [Dataset]; Dryad; Version 1; https://doi.org/10.5061/dryad.6rb12hk
http://dx.doi.org/10.1111/jeb.13379
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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