A pragmatic guide for management of adverse events associated with lorlatinib
Anaplastic lymphoma kinase; Carcinoma; Tyrosine kinase inhibitors
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/11297 |
| Acceso en línea: | https://hdl.handle.net/11351/11297 |
| Access Level: | acceso abierto |
| Palabra clave: | Pulmons - Càncer - Tractament Proteïnes quinases - Inhibidors - Ús terapèutic - Efectes secundaris DISEASES::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms::Bronchial Neoplasms::Carcinoma, Bronchogenic::Carcinoma, Non-Small-Cell Lung Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protein Kinase Inhibitors Other subheadings::Other subheadings::Other subheadings::/adverse effects ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias torácicas::neoplasias del tracto respiratorio::neoplasias pulmonares::neoplasias de los bronquios::carcinoma broncogénico::carcinoma de pulmón de células no pequeñas Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::inhibidores enzimáticos::inhibidores de proteínas cinasas Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos |
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| dc.title.none.fl_str_mv |
A pragmatic guide for management of adverse events associated with lorlatinib |
| title |
A pragmatic guide for management of adverse events associated with lorlatinib |
| spellingShingle |
A pragmatic guide for management of adverse events associated with lorlatinib Liu, Geoffrey Pulmons - Càncer - Tractament Proteïnes quinases - Inhibidors - Ús terapèutic - Efectes secundaris DISEASES::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms::Bronchial Neoplasms::Carcinoma, Bronchogenic::Carcinoma, Non-Small-Cell Lung Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protein Kinase Inhibitors Other subheadings::Other subheadings::Other subheadings::/adverse effects ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias torácicas::neoplasias del tracto respiratorio::neoplasias pulmonares::neoplasias de los bronquios::carcinoma broncogénico::carcinoma de pulmón de células no pequeñas Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::inhibidores enzimáticos::inhibidores de proteínas cinasas Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos |
| title_short |
A pragmatic guide for management of adverse events associated with lorlatinib |
| title_full |
A pragmatic guide for management of adverse events associated with lorlatinib |
| title_fullStr |
A pragmatic guide for management of adverse events associated with lorlatinib |
| title_full_unstemmed |
A pragmatic guide for management of adverse events associated with lorlatinib |
| title_sort |
A pragmatic guide for management of adverse events associated with lorlatinib |
| dc.creator.none.fl_str_mv |
Liu, Geoffrey Stratmann, Jan Ou, Sai-Hong Mok, Tony MAZIERES, JULIEN Bauer, Todd FELIP, ENRIQUETA |
| author |
Liu, Geoffrey |
| author_facet |
Liu, Geoffrey Stratmann, Jan Ou, Sai-Hong Mok, Tony MAZIERES, JULIEN Bauer, Todd FELIP, ENRIQUETA |
| author_role |
author |
| author2 |
Stratmann, Jan Ou, Sai-Hong Mok, Tony MAZIERES, JULIEN Bauer, Todd FELIP, ENRIQUETA |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Liu G] Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. [Mazieres J] Thoracic Oncology Department, Toulouse University Hospital, Toulouse, France. [Stratmann J] Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, and National Network Genomic Medicine Lung Cancer, Cologne, Germany. [Ignatius Ou SH] Chao Comprehensive Cancer Center, University of California Irvine School of Medicine, Orange, CA, USA. [Mok T] State Key Laboratory of South China, Chinese University of Hong Kong, Hong Kong Special Administrative Region of China, China. [Grizzard M] Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN, USA. [Felip E] Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Pulmons - Càncer - Tractament Proteïnes quinases - Inhibidors - Ús terapèutic - Efectes secundaris DISEASES::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms::Bronchial Neoplasms::Carcinoma, Bronchogenic::Carcinoma, Non-Small-Cell Lung Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protein Kinase Inhibitors Other subheadings::Other subheadings::Other subheadings::/adverse effects ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias torácicas::neoplasias del tracto respiratorio::neoplasias pulmonares::neoplasias de los bronquios::carcinoma broncogénico::carcinoma de pulmón de células no pequeñas Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::inhibidores enzimáticos::inhibidores de proteínas cinasas Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos |
| topic |
Pulmons - Càncer - Tractament Proteïnes quinases - Inhibidors - Ús terapèutic - Efectes secundaris DISEASES::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms::Bronchial Neoplasms::Carcinoma, Bronchogenic::Carcinoma, Non-Small-Cell Lung Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protein Kinase Inhibitors Other subheadings::Other subheadings::Other subheadings::/adverse effects ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias torácicas::neoplasias del tracto respiratorio::neoplasias pulmonares::neoplasias de los bronquios::carcinoma broncogénico::carcinoma de pulmón de células no pequeñas Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::inhibidores enzimáticos::inhibidores de proteínas cinasas Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos |
| description |
Anaplastic lymphoma kinase; Carcinoma; Tyrosine kinase inhibitors |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/11297 |
| url |
https://hdl.handle.net/11351/11297 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Lung Cancer;191 https://doi.org/10.1016/j.lungcan.2024.107535 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
| instname_str |
Departament de Salut de la Generalitat de Catalunya (DS) |
| reponame_str |
Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| collection |
Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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|
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| _version_ |
1869406836611874816 |
| spelling |
A pragmatic guide for management of adverse events associated with lorlatinibLiu, GeoffreyStratmann, JanOu, Sai-HongMok, TonyMAZIERES, JULIENBauer, ToddFELIP, ENRIQUETAPulmons - Càncer - TractamentProteïnes quinases - Inhibidors - Ús terapèutic - Efectes secundarisDISEASES::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms::Bronchial Neoplasms::Carcinoma, Bronchogenic::Carcinoma, Non-Small-Cell LungOther subheadings::Other subheadings::Other subheadings::/drug therapyCHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protein Kinase InhibitorsOther subheadings::Other subheadings::Other subheadings::/adverse effectsENFERMEDADES::neoplasias::neoplasias por localización::neoplasias torácicas::neoplasias del tracto respiratorio::neoplasias pulmonares::neoplasias de los bronquios::carcinoma broncogénico::carcinoma de pulmón de células no pequeñasOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaCOMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::inhibidores enzimáticos::inhibidores de proteínas cinasasOtros calificadores::Otros calificadores::Otros calificadores::/efectos adversosAnaplastic lymphoma kinase; Carcinoma; Tyrosine kinase inhibitorsLinfoma quinasa anaplásico; Carcinoma; Inhibidores de la tirosina quinasaLimfoma quinasa anaplàstic; Carcinoma; Inhibidors de la tirosina cinasaLorlatinib is a brain-penetrant, third-generation tyrosine kinase inhibitor (TKI) indicated for the treatment of anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC). In clinical trials, lorlatinib has shown durable efficacy and a manageable safety profile in treatment-naive patients and in those who have experienced progression while receiving first- and/or second-generation ALK TKIs. Lorlatinib has a distinct safety profile from other ALK TKIs, including hyperlipidemia and central nervous system effects. Clinical trial data showed that most adverse events (AEs) can be managed effectively or reversed with dose modifications (such as dose interruptions or reductions) or with concomitant medications without compromising clinical efficacy or quality of life for patients. A pragmatic approach to managing AEs related to lorlatinib is required. We present patient-focused recommendations for the evaluation and management of select AEs associated with lorlatinib developed by clinicians and nurses with extensive lorlatinib expertise in routine clinical practice. The recommendations follow the general framework of “prepare, monitor, manage, reassess” to streamline AE management and assist in practical, actionable, and personalized patient care.Development of this report was funded by Pfizer.ElsevierInstitut Català de la Salut[Liu G] Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. [Mazieres J] Thoracic Oncology Department, Toulouse University Hospital, Toulouse, France. [Stratmann J] Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, and National Network Genomic Medicine Lung Cancer, Cologne, Germany. [Ignatius Ou SH] Chao Comprehensive Cancer Center, University of California Irvine School of Medicine, Orange, CA, USA. [Mok T] State Key Laboratory of South China, Chinese University of Hong Kong, Hong Kong Special Administrative Region of China, China. [Grizzard M] Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN, USA. [Felip E] Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/11297Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésLung Cancer;191https://doi.org/10.1016/j.lungcan.2024.107535Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/112972026-06-12T09:38:37Z |
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15,811543 |