Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9
The BCR-ABL1 fusion kinase is frequently associated with chronic myeloid leukemia and B-cell acute lymphoblastic leukemia but is rare in T-cell acute lymphoblastic leukemia (T-ALL). We recently identified NUP214-ABL1 as a variant ABL1 fusion gene in 6% of T-ALL patients. Here we describe the identif...
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2005 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/19475 |
| Acceso en línea: | https://hdl.handle.net/10171/19475 |
| Access Level: | acceso abierto |
| Palabra clave: | Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 9 Leukemia, T-Cell/pathology Oncogene Proteins, Fusion/genetics Translocation, Genetic |
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Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(914)(q34q32)Keersmaecker, K. (K.) de|||/items/258c506a-012b-4be6-a863-6355e369a5afGraux, C. (Carlos)|||/items/81f2276f-8eae-48fa-bf6c-94c590948b6bOdero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251Mentens, N. (Nicole)|||/items/96148ec7-7ad9-47c9-9b40-9100d37fc6a8Somers, R. (Riet)|||/items/ffbb351b-5104-4353-9aa1-70430d22ddc6Maertens, J. (Johan)|||/items/e22ecb0f-9e40-4ce7-af6e-811de304436bWlodarska, I. (Iwona)|||/items/09e7617d-b7d5-4e09-ac5b-49d898e8a4c2Vandenberghe, P. (Peter)|||/items/f15790d4-17b6-4acb-9364-b74c1a0ac2d3Hagemeijer, A. (A.)|||/items/b3d6a162-3956-49b8-999d-6a50fcee7ae0Marynen, P. (Peter)|||/items/24665a62-a4ab-456b-88c5-b2788fccd2d1Cools, J. (J.)|||/items/66551df7-4b7f-4200-ae5e-f361ba0fa108Chromosomes, Human, Pair 14Chromosomes, Human, Pair 9Leukemia, T-Cell/pathologyOncogene Proteins, Fusion/geneticsTranslocation, GeneticThe BCR-ABL1 fusion kinase is frequently associated with chronic myeloid leukemia and B-cell acute lymphoblastic leukemia but is rare in T-cell acute lymphoblastic leukemia (T-ALL). We recently identified NUP214-ABL1 as a variant ABL1 fusion gene in 6% of T-ALL patients. Here we describe the identification of another ABL1 fusion, EML1-ABL1, in a T-ALL patient with a cryptic t(9;14)(q34;q32) associated with deletion of CDKN2A (p16) and expression of TLX1 (HOX11). Echinoderm microtubule-associated protein-like 1-Abelson 1 (EML1-ABL1) is a constitutively phosphorylated tyrosine kinase that transforms Ba/F3 cells to growth factor-independent growth through activation of survival and proliferation pathways, including extracellular signal-related kinase 1/2 (Erk1/2), signal transducers and activators of transcription 5 (Stat5), and Lyn kinase. Deletion of the coiled-coil domain of EML1 abrogated the transforming properties of the fusion kinase. EML1-ABL1 and breakpoint cluster region (BCR)-ABL1 were equally sensitive to the tyrosine kinase inhibitor imatinib. These data further demonstrate the involvement of ABL1 fusions in the pathogenesis of T-ALL and identify EML1-ABL1 as a novel therapeutic target of imatinib.American Society of HematologyDadun. Depósito Académico Digital Universidad de Navarra20112011-11-0920052005-01-0120052005-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/19475reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/194752026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9 14)(q34 q32) |
| title |
Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9 |
| spellingShingle |
Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9 Keersmaecker, K. (K.) de|||/items/258c506a-012b-4be6-a863-6355e369a5af Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 9 Leukemia, T-Cell/pathology Oncogene Proteins, Fusion/genetics Translocation, Genetic |
| title_short |
Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9 |
| title_full |
Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9 |
| title_fullStr |
Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9 |
| title_full_unstemmed |
Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9 |
| title_sort |
Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9 |
| dc.creator.none.fl_str_mv |
Keersmaecker, K. (K.) de|||/items/258c506a-012b-4be6-a863-6355e369a5af Graux, C. (Carlos)|||/items/81f2276f-8eae-48fa-bf6c-94c590948b6b Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251 Mentens, N. (Nicole)|||/items/96148ec7-7ad9-47c9-9b40-9100d37fc6a8 Somers, R. (Riet)|||/items/ffbb351b-5104-4353-9aa1-70430d22ddc6 Maertens, J. (Johan)|||/items/e22ecb0f-9e40-4ce7-af6e-811de304436b Wlodarska, I. (Iwona)|||/items/09e7617d-b7d5-4e09-ac5b-49d898e8a4c2 Vandenberghe, P. (Peter)|||/items/f15790d4-17b6-4acb-9364-b74c1a0ac2d3 Hagemeijer, A. (A.)|||/items/b3d6a162-3956-49b8-999d-6a50fcee7ae0 Marynen, P. (Peter)|||/items/24665a62-a4ab-456b-88c5-b2788fccd2d1 Cools, J. (J.)|||/items/66551df7-4b7f-4200-ae5e-f361ba0fa108 |
| author |
Keersmaecker, K. (K.) de|||/items/258c506a-012b-4be6-a863-6355e369a5af |
| author_facet |
Keersmaecker, K. (K.) de|||/items/258c506a-012b-4be6-a863-6355e369a5af Graux, C. (Carlos)|||/items/81f2276f-8eae-48fa-bf6c-94c590948b6b Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251 Mentens, N. (Nicole)|||/items/96148ec7-7ad9-47c9-9b40-9100d37fc6a8 Somers, R. (Riet)|||/items/ffbb351b-5104-4353-9aa1-70430d22ddc6 Maertens, J. (Johan)|||/items/e22ecb0f-9e40-4ce7-af6e-811de304436b Wlodarska, I. (Iwona)|||/items/09e7617d-b7d5-4e09-ac5b-49d898e8a4c2 Vandenberghe, P. (Peter)|||/items/f15790d4-17b6-4acb-9364-b74c1a0ac2d3 Hagemeijer, A. (A.)|||/items/b3d6a162-3956-49b8-999d-6a50fcee7ae0 Marynen, P. (Peter)|||/items/24665a62-a4ab-456b-88c5-b2788fccd2d1 Cools, J. (J.)|||/items/66551df7-4b7f-4200-ae5e-f361ba0fa108 |
| author_role |
author |
| author2 |
Graux, C. (Carlos)|||/items/81f2276f-8eae-48fa-bf6c-94c590948b6b Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251 Mentens, N. (Nicole)|||/items/96148ec7-7ad9-47c9-9b40-9100d37fc6a8 Somers, R. (Riet)|||/items/ffbb351b-5104-4353-9aa1-70430d22ddc6 Maertens, J. (Johan)|||/items/e22ecb0f-9e40-4ce7-af6e-811de304436b Wlodarska, I. (Iwona)|||/items/09e7617d-b7d5-4e09-ac5b-49d898e8a4c2 Vandenberghe, P. (Peter)|||/items/f15790d4-17b6-4acb-9364-b74c1a0ac2d3 Hagemeijer, A. (A.)|||/items/b3d6a162-3956-49b8-999d-6a50fcee7ae0 Marynen, P. (Peter)|||/items/24665a62-a4ab-456b-88c5-b2788fccd2d1 Cools, J. (J.)|||/items/66551df7-4b7f-4200-ae5e-f361ba0fa108 |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 9 Leukemia, T-Cell/pathology Oncogene Proteins, Fusion/genetics Translocation, Genetic |
| topic |
Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 9 Leukemia, T-Cell/pathology Oncogene Proteins, Fusion/genetics Translocation, Genetic |
| description |
The BCR-ABL1 fusion kinase is frequently associated with chronic myeloid leukemia and B-cell acute lymphoblastic leukemia but is rare in T-cell acute lymphoblastic leukemia (T-ALL). We recently identified NUP214-ABL1 as a variant ABL1 fusion gene in 6% of T-ALL patients. Here we describe the identification of another ABL1 fusion, EML1-ABL1, in a T-ALL patient with a cryptic t(9;14)(q34;q32) associated with deletion of CDKN2A (p16) and expression of TLX1 (HOX11). Echinoderm microtubule-associated protein-like 1-Abelson 1 (EML1-ABL1) is a constitutively phosphorylated tyrosine kinase that transforms Ba/F3 cells to growth factor-independent growth through activation of survival and proliferation pathways, including extracellular signal-related kinase 1/2 (Erk1/2), signal transducers and activators of transcription 5 (Stat5), and Lyn kinase. Deletion of the coiled-coil domain of EML1 abrogated the transforming properties of the fusion kinase. EML1-ABL1 and breakpoint cluster region (BCR)-ABL1 were equally sensitive to the tyrosine kinase inhibitor imatinib. These data further demonstrate the involvement of ABL1 fusions in the pathogenesis of T-ALL and identify EML1-ABL1 as a novel therapeutic target of imatinib. |
| publishDate |
2005 |
| dc.date.none.fl_str_mv |
2005 2005-01-01 2005 2005-01-01 2011 2011-11-09 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/19475 |
| url |
https://hdl.handle.net/10171/19475 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
American Society of Hematology |
| publisher.none.fl_str_mv |
American Society of Hematology |
| dc.source.none.fl_str_mv |
reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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1869406832063152128 |
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15,301603 |