Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the ILERVAS project

Factors de risc cardiovascular; Malaltia ateromàtica subclínica; Prediabetes

Bibliographic Details
Authors: Betriu, Ángeles, López-Cano, Carolina, Fernández, Elvira, Hernández Pascual, Cristina, Simó Canonge, Rafael, Sánchez, Enric, Purroy, Francisco, Hernández, Marta
Format: article
Status:Published version
Publication Date:2019
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/5835
Online Access:https://hdl.handle.net/11351/5835
Access Level:Open access
Keyword:Prediabetis
Aterosclerosi
DISEASES::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Prediabetic State
DISEASES::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosis::Atherosclerosis
ENFERMEDADES::enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus::estado prediabético
ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::arteriopatías oclusivas::arteriosclerosis::aterosclerosis
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network_acronym_str ES
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dc.title.none.fl_str_mv Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the ILERVAS project
title Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the ILERVAS project
spellingShingle Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the ILERVAS project
Betriu, Ángeles
Prediabetis
Aterosclerosi
DISEASES::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Prediabetic State
DISEASES::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosis::Atherosclerosis
ENFERMEDADES::enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus::estado prediabético
ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::arteriopatías oclusivas::arteriosclerosis::aterosclerosis
title_short Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the ILERVAS project
title_full Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the ILERVAS project
title_fullStr Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the ILERVAS project
title_full_unstemmed Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the ILERVAS project
title_sort Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the ILERVAS project
dc.creator.none.fl_str_mv Betriu, Ángeles
López-Cano, Carolina
Fernández, Elvira
Hernández Pascual, Cristina
Simó Canonge, Rafael
Sánchez, Enric
Purroy, Francisco
Hernández, Marta
author Betriu, Ángeles
author_facet Betriu, Ángeles
López-Cano, Carolina
Fernández, Elvira
Hernández Pascual, Cristina
Simó Canonge, Rafael
Sánchez, Enric
Purroy, Francisco
Hernández, Marta
author_role author
author2 López-Cano, Carolina
Fernández, Elvira
Hernández Pascual, Cristina
Simó Canonge, Rafael
Sánchez, Enric
Purroy, Francisco
Hernández, Marta
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Sánchez E, López-Cano C, Hernández M] Endocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) research Group, IRBLleida, University of Lleida, Lleida, Spain. [Betriu À, Fernández E] Vascular and Renal Translational Research Group, IRBLleida, RedinRen-ISCIII, Lleida, Spain. [Purroy F] Stroke Unit, University Hospital Arnau de Vilanova, Clinical Neurosciences Group. IRBLleida, University of Lleida, Lleida, Spain. [Hernández C, Simó R] Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Prediabetis
Aterosclerosi
DISEASES::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Prediabetic State
DISEASES::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosis::Atherosclerosis
ENFERMEDADES::enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus::estado prediabético
ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::arteriopatías oclusivas::arteriosclerosis::aterosclerosis
topic Prediabetis
Aterosclerosi
DISEASES::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Prediabetic State
DISEASES::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosis::Atherosclerosis
ENFERMEDADES::enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus::estado prediabético
ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::arteriopatías oclusivas::arteriosclerosis::aterosclerosis
description Factors de risc cardiovascular; Malaltia ateromàtica subclínica; Prediabetes
publishDate 2019
dc.date.none.fl_str_mv 2019
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/5835
url https://hdl.handle.net/11351/5835
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cardiovascular Diabetology;18(1)
https://cardiab.biomedcentral.com/articles/10.1186/s12933-019-0962-6
info:eu-repo/grantAgreement/ES/PERIS2016-2020/2017SGR696
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406824149549056
spelling Characteristics of atheromatosis in the prediabetes stage: a cross-sectional investigation of the ILERVAS projectBetriu, ÁngelesLópez-Cano, CarolinaFernández, ElviraHernández Pascual, CristinaSimó Canonge, RafaelSánchez, EnricPurroy, FranciscoHernández, MartaPrediabetisAterosclerosiDISEASES::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Prediabetic StateDISEASES::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosis::AtherosclerosisENFERMEDADES::enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus::estado prediabéticoENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::arteriopatías oclusivas::arteriosclerosis::aterosclerosisFactors de risc cardiovascular; Malaltia ateromàtica subclínica; PrediabetesFactores de riesgo cardiovascular; Enfermedad ateromatosa subclínica; PrediabetesCardiovascular risk factors; Subclinical atheromatous disease; PrediabetesBackground Prediabetes has recently been associated with subclinical atheromatous disease in the middle-aged population. Our aim was to characterize atheromatous plaque burden by the number of affected territories and the total plaque area in the prediabetes stage. Methods Atheromatous plaque burden (quantity of plaques and total plaque area) was assessed in 12 territories from the carotid and femoral regions using ultrasonography in 6688 non-diabetic middle-aged subjects without cardiovascular disease. Prediabetes was defined by glycosylated hemoglobin (HbA1c) between 5.7 and 6.4% according to the American Diabetes Association guidelines. Results Prediabetes was diagnosed in 33.9% (n = 2269) of the ILERVAS participants. Subjects with prediabetes presented a higher prevalence of subclinical atheromatous disease than participants with HbA1c < 5.7% (70.4 vs. 67.5%, p = 0.017). In the population with prediabetes this was observed at the level of the carotid territory (p < 0.001), but not in the femoral arteries. Participants in the prediabetes stage also presented a significantly higher number of affected territories (2 [1;3] vs. 1 [0;3], p = 0.002), with a positive correlation between HbA1c levels and the number of affected territories (r = 0.068, p < 0.001). However, atheromatosis was only significantly (p = 0.016) magnified by prediabetes in those subjects with 3 or more cardiovascular risk factors. The multivariable logistic regression model showed that the well-established cardiovascular risk factors together with HbA1c were independently associated with the presence of atheromatous disease in participants with prediabetes. When males and females were analyzed separately, we found that only men with prediabetes presented both carotid and femoral atherosclerosis, as well as an increase of total plaque area in comparison with non-prediabetic subjects.This work was partially supported by grants from the Diputació de Lleida and the Generalitat de Catalunya (2017SGR696 and SLT0021600250) and Menarini Spain S.A. CIBER de Diabetes y Enfermedades Metabólicas Asociadas and CIBER de Enfermedades Respiratorias are initiatives of the Instituto de Salud Carlos III.BMCInstitut Català de la Salut[Sánchez E, López-Cano C, Hernández M] Endocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) research Group, IRBLleida, University of Lleida, Lleida, Spain. [Betriu À, Fernández E] Vascular and Renal Translational Research Group, IRBLleida, RedinRen-ISCIII, Lleida, Spain. [Purroy F] Stroke Unit, University Hospital Arnau de Vilanova, Clinical Neurosciences Group. IRBLleida, University of Lleida, Lleida, Spain. [Hernández C, Simó R] Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, SpainVall d'Hebron Barcelona Hospital Campus202120212019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/5835Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCardiovascular Diabetology;18(1)https://cardiab.biomedcentral.com/articles/10.1186/s12933-019-0962-6info:eu-repo/grantAgreement/ES/PERIS2016-2020/2017SGR696Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/58352026-05-29T05:05:01Z
score 15,811543

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