The mammalian testis-specific thioredoxin system

41 páginas, 8 figuras, 1 tabla.

Detalhes bibliográficos
Autores: Miranda-Vizuete, Antonio, Sadek, Christine M., Jiménez, Alberto, Krause, William J., Sutovsky, Peter, Oko, Richard
Formato: artículo
Fecha de publicación:2004
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/46477
Acesso em linha:http://hdl.handle.net/10261/46477
Access Level:acceso abierto
Palavra-chave:Oxidation-reduction
Phylogeny
Spermatids
Spermatozoa
Testis
Thioredoxin-disulfide reductase
Thioredoxins
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spelling The mammalian testis-specific thioredoxin systemMiranda-Vizuete, AntonioSadek, Christine M.Jiménez, AlbertoKrause, William J.Sutovsky, PeterOko, RichardOxidation-reductionPhylogenySpermatidsSpermatozoaTestisThioredoxin-disulfide reductaseThioredoxins41 páginas, 8 figuras, 1 tabla.Redox control of cell physiology is one of the most important regulatory mechanisms in all living organisms. The thioredoxin system, composed of thioredoxin and thioredoxin reductase, has emerged as a key player in cellular redox-mediated reactions. For many years, only one thioredoxin system had been described in higher organisms, ubiquitously expressed in the cytoplasm of eukaryotic cells. However, during the last decade, we and others have identified and characterized novel thioredoxin systems with unique properties, such as organelle-specific localization in mitochondria or endoplasmic reticulum, tissue-specific distribution mostly in the testis, and features novel for thioredoxins, such as microtubule-binding properties. In this review, we will focus on the mammalian testis-specific thioredoxin system that comprises three thioredoxins exclusively expressed in spermatids (named Sptrx-1, Sptrx-2, and Sptrx-3) and an additional thioredoxin highly expressed in testis, but also present in lung and other ciliated tissues (Txl-2). The implications of these findings in the context of male fertility and testicular cancer, as well as evolutionary aspects, will be discussed.This work was supported by grants from the Swedish Medical Research Council (Projects 03P-14096 and 32X-1473), the Åke Wibergs Stiftelse and the Karolinska Institutet to A.M.-V.; the Canadian Institute of Health Research and NSERC grants to R.O.; the Fundación Margit and Folke Pehrzon to A. J.; the Food for the 21st Century Program of the University of Missouri-Columbia, grants from USDA (2002-02069; 99-35203-7785) and NIH/NIOSH (OH07324-01) to P.S.Peer reviewedMary Ann Liebert201220122004info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/46477reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1089/152308604771978327info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/464772026-05-22T06:33:51Z
dc.title.none.fl_str_mv The mammalian testis-specific thioredoxin system
title The mammalian testis-specific thioredoxin system
spellingShingle The mammalian testis-specific thioredoxin system
Miranda-Vizuete, Antonio
Oxidation-reduction
Phylogeny
Spermatids
Spermatozoa
Testis
Thioredoxin-disulfide reductase
Thioredoxins
title_short The mammalian testis-specific thioredoxin system
title_full The mammalian testis-specific thioredoxin system
title_fullStr The mammalian testis-specific thioredoxin system
title_full_unstemmed The mammalian testis-specific thioredoxin system
title_sort The mammalian testis-specific thioredoxin system
dc.creator.none.fl_str_mv Miranda-Vizuete, Antonio
Sadek, Christine M.
Jiménez, Alberto
Krause, William J.
Sutovsky, Peter
Oko, Richard
author Miranda-Vizuete, Antonio
author_facet Miranda-Vizuete, Antonio
Sadek, Christine M.
Jiménez, Alberto
Krause, William J.
Sutovsky, Peter
Oko, Richard
author_role author
author2 Sadek, Christine M.
Jiménez, Alberto
Krause, William J.
Sutovsky, Peter
Oko, Richard
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Oxidation-reduction
Phylogeny
Spermatids
Spermatozoa
Testis
Thioredoxin-disulfide reductase
Thioredoxins
topic Oxidation-reduction
Phylogeny
Spermatids
Spermatozoa
Testis
Thioredoxin-disulfide reductase
Thioredoxins
description 41 páginas, 8 figuras, 1 tabla.
publishDate 2004
dc.date.none.fl_str_mv 2004
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/46477
url http://hdl.handle.net/10261/46477
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1089/152308604771978327
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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