Epigenetic regulation of inflammation by microRNAs in post-infectious bronchiolitis obliterans

Inflammation; MicroRNA; Post‐infectious bronchiolitis obliterans

Detalles Bibliográficos
Autores: Duecker, Ruth Pia, de Mir Messa, Inés, Jerkic, Silvija-Pera, Kochems, Annalena, Gottwald, Gabriele, Moreno Galdó, Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/7885
Acceso en línea:https://hdl.handle.net/11351/7885
http://hdl.handle.net/11351/7885
Access Level:acceso abierto
Palabra clave:Bronquiolitis
MicroARN
Epigenètica
DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Bronchitis::Bronchiolitis::Bronchiolitis Obliterans
ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquitis::bronquiolitis::bronquiolitis obliterante
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spelling Epigenetic regulation of inflammation by microRNAs in post-infectious bronchiolitis obliteransDuecker, Ruth Piade Mir Messa, InésJerkic, Silvija-PeraKochems, AnnalenaGottwald, GabrieleMoreno Galdó, AntonioBronquiolitisMicroARNEpigenèticaDISEASES::Respiratory Tract Diseases::Bronchial Diseases::Bronchitis::Bronchiolitis::Bronchiolitis ObliteransENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquitis::bronquiolitis::bronquiolitis obliteranteInflammation; MicroRNA; Post‐infectious bronchiolitis obliteransInflamación; MicroARN; Bronquiolitis obliterante posinfecciosaInflamació; MicroARN; Bronquiolitis obliterant postinfecciosaObjectives Post-infectious bronchiolitis obliterans (PiBO) is a rare, chronic disease initiated by severe infection and followed by perpetuating inflammation and obliteration of the small airways. MicroRNAs (miRNAs) have been proposed to play a central role as epigenetic regulators, which control resolution and prevent the uncontrolled progress of inflammation. The aim of this study was to define biomarkers on the level of post-transcriptional gene regulation in order to characterise PiBO. Methods A total of 39 patients with well-defined PiBO and 31 controls from two centres, Barcelona, Spain, and Frankfurt, Germany, were analysed by next-generation sequencing (NGS). The evaluation of the biological targets of the miRNAs was performed by pathway enrichment analysis and protein–protein interaction network analysis respectively. Results Patients with PiBO had significantly lower lung function values and increased airway inflammation in induced sputum as indicated by total cell counts, neutrophils, IL-1β, IL-6, IL-8 and TGF-β compared to controls. Next-generation sequencing analysis revealed a total of 22 dysregulated miRNAs, which passed significance threshold for Padj ≤ 0.001 with 17 being upregulated and 5 being downregulated. Of these dysregulated miRNAs, miR-335-5p, miR-186-5p, miR-30b-5p and miR-30c-5p were further validated using qRT-PCR. Interestingly, these miRNAs are functionally implicated in cytokine–cytokine receptor interaction, TGF-β signalling and FoxO signalling pathway and significantly correlated with lung function values (FEV1). Conclusion Our results demonstrate an aberrant miRNA expression profile in PiBO, which impacts pathways responsible for the regulation of inflammation and fibrosis. The defined miRNAs are useful biomarkers and should be assessed as potential target in the field of miRNA therapeutics.Starke Lunge Foundation. Grant Number: I 1325d 04/11(6)-78WileyInstitut Català de la Salut[Duecker RP, Jerkic SP, Kochems A, Gottwald G] Division for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, Goethe University, Frankfurt, Germany. [De Mir Messa I] Unitat de Pneumologia Pediàtrica i Fibrosi Quística, Servei de Pediatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Moreno-Galdó A] Unitat de Pneumologia Pediàtrica i Fibrosi Quística, Servei de Pediatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER of Rare Diseases (CIBERER), Instituto de Salud Carlos III (ISCIII), Madrid, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7885http://hdl.handle.net/11351/7885Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésClinical & Translational Immunology;11(2)https://doi.org/10.1002/cti2.1376Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/78852026-05-29T05:05:01Z
dc.title.none.fl_str_mv Epigenetic regulation of inflammation by microRNAs in post-infectious bronchiolitis obliterans
title Epigenetic regulation of inflammation by microRNAs in post-infectious bronchiolitis obliterans
spellingShingle Epigenetic regulation of inflammation by microRNAs in post-infectious bronchiolitis obliterans
Duecker, Ruth Pia
Bronquiolitis
MicroARN
Epigenètica
DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Bronchitis::Bronchiolitis::Bronchiolitis Obliterans
ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquitis::bronquiolitis::bronquiolitis obliterante
title_short Epigenetic regulation of inflammation by microRNAs in post-infectious bronchiolitis obliterans
title_full Epigenetic regulation of inflammation by microRNAs in post-infectious bronchiolitis obliterans
title_fullStr Epigenetic regulation of inflammation by microRNAs in post-infectious bronchiolitis obliterans
title_full_unstemmed Epigenetic regulation of inflammation by microRNAs in post-infectious bronchiolitis obliterans
title_sort Epigenetic regulation of inflammation by microRNAs in post-infectious bronchiolitis obliterans
dc.creator.none.fl_str_mv Duecker, Ruth Pia
de Mir Messa, Inés
Jerkic, Silvija-Pera
Kochems, Annalena
Gottwald, Gabriele
Moreno Galdó, Antonio
author Duecker, Ruth Pia
author_facet Duecker, Ruth Pia
de Mir Messa, Inés
Jerkic, Silvija-Pera
Kochems, Annalena
Gottwald, Gabriele
Moreno Galdó, Antonio
author_role author
author2 de Mir Messa, Inés
Jerkic, Silvija-Pera
Kochems, Annalena
Gottwald, Gabriele
Moreno Galdó, Antonio
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Duecker RP, Jerkic SP, Kochems A, Gottwald G] Division for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, Goethe University, Frankfurt, Germany. [De Mir Messa I] Unitat de Pneumologia Pediàtrica i Fibrosi Quística, Servei de Pediatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Moreno-Galdó A] Unitat de Pneumologia Pediàtrica i Fibrosi Quística, Servei de Pediatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER of Rare Diseases (CIBERER), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Bronquiolitis
MicroARN
Epigenètica
DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Bronchitis::Bronchiolitis::Bronchiolitis Obliterans
ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquitis::bronquiolitis::bronquiolitis obliterante
topic Bronquiolitis
MicroARN
Epigenètica
DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Bronchitis::Bronchiolitis::Bronchiolitis Obliterans
ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquitis::bronquiolitis::bronquiolitis obliterante
description Inflammation; MicroRNA; Post‐infectious bronchiolitis obliterans
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7885
http://hdl.handle.net/11351/7885
url https://hdl.handle.net/11351/7885
http://hdl.handle.net/11351/7885
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Clinical & Translational Immunology;11(2)
https://doi.org/10.1002/cti2.1376
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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