Fish pigmentation and the melanocortin system

8 pages, 4 figures

Detalles Bibliográficos
Autores: Cal, Laura, Suárez-Bregua, Paula, Cerdá-Reverter, José Miguel, Braasch, Ingo, Rotllant, Josep
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/192904
Acceso en línea:http://hdl.handle.net/10261/192904
Access Level:acceso abierto
Palabra clave:α-Msh
Asip
Fish
Mc1r
Pigmentation
Pomc
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oai_identifier_str oai:digital.csic.es:10261/192904
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repository_id_str
spelling Fish pigmentation and the melanocortin systemCal, LauraSuárez-Bregua, PaulaCerdá-Reverter, José MiguelBraasch, IngoRotllant, Josepα-MshAsipFishMc1rPigmentationPomc8 pages, 4 figuresThe melanocortin system is a complex neuroendocrine signaling mechanism involved in numerous physiological processes in vertebrates, including pigmentation, steroidogenesis and metabolic control. This review focuses at one of its most fascinating function in fish, its regulatory role in the control of pigmentation, in which the melanocortin 1 receptor (Mc1r), its agonist α-melanocyte stimulating hormone (α-Msh), and the endogenous antagonist agouti signaling protein (Asip1) are the main players. Functional control of Mc1r, which is highly expressed in fish skin and whose activation stimulates melanin production and melanosome dispersion in fish melanophores, is considered a key mechanism for vertebrate pigment phenotypes. The α-Msh peptide, the most documented Mc1r agonist involved in pigmentation, is produced in the pituitary gland, activating melanin synthesis by binding to Mc1r in fish melanophores. Finally, Asip1 is the putative factor for establishing the evolutionarily conserved dorso-ventral pigment pattern found across vertebrates. However, we are just starting to understand how other melanocortin system components are acting in this complex regulatory networkThis work was funded by the Spanish Ministry of Economy and Competitiveness projects ALG2011-23581 and AGL2014-52473R to JR. Laura Cal was supported by Spanish Ministry of Economy and Competitiveness FPI grant BES-2012-055414. Paula Suarez-Bregua was supported by a Campus do Mar PhD grant, Xunta de Galicia and AGL2014-52473R project contractPeer reviewedElsevierMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/192904reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-52473-Rhttps://doi.org/10.1016/j.cbpa.2017.06.001Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1929042026-05-22T06:33:51Z
dc.title.none.fl_str_mv Fish pigmentation and the melanocortin system
title Fish pigmentation and the melanocortin system
spellingShingle Fish pigmentation and the melanocortin system
Cal, Laura
α-Msh
Asip
Fish
Mc1r
Pigmentation
Pomc
title_short Fish pigmentation and the melanocortin system
title_full Fish pigmentation and the melanocortin system
title_fullStr Fish pigmentation and the melanocortin system
title_full_unstemmed Fish pigmentation and the melanocortin system
title_sort Fish pigmentation and the melanocortin system
dc.creator.none.fl_str_mv Cal, Laura
Suárez-Bregua, Paula
Cerdá-Reverter, José Miguel
Braasch, Ingo
Rotllant, Josep
author Cal, Laura
author_facet Cal, Laura
Suárez-Bregua, Paula
Cerdá-Reverter, José Miguel
Braasch, Ingo
Rotllant, Josep
author_role author
author2 Suárez-Bregua, Paula
Cerdá-Reverter, José Miguel
Braasch, Ingo
Rotllant, Josep
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv α-Msh
Asip
Fish
Mc1r
Pigmentation
Pomc
topic α-Msh
Asip
Fish
Mc1r
Pigmentation
Pomc
description 8 pages, 4 figures
publishDate 2017
dc.date.none.fl_str_mv 2017
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/192904
url http://hdl.handle.net/10261/192904
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-52473-R
https://doi.org/10.1016/j.cbpa.2017.06.001
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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