MELI-POP Study: MEditerranean LIfestyle in Pediatric Obesity Prevention. Study protocol for a randomized controlled trial
Background Childhood obesity is a significant public health challenge, with Mediterranean countries showing high prevalence rates. While genetic factors play a role, diet and physical activity (PA) are critical modifiable influences. Emphasizing healthy dietary patterns, like the Mediterranean diet,...
| Autores: | , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglés |
| OAI Identifier: | oai:minerva.usc.gal:10347/45267 |
| Acceso en línea: | https://hdl.handle.net/10347/45267 |
| Access Level: | acceso abierto |
| Palabra clave: | Obesity prevention Mediterranean Diet Physical Activity Pediatric obesity 3201 Ciencias clínicas |
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MELI-POP Study: MEditerranean LIfestyle in Pediatric Obesity Prevention. Study protocol for a randomized controlled trial |
| title |
MELI-POP Study: MEditerranean LIfestyle in Pediatric Obesity Prevention. Study protocol for a randomized controlled trial |
| spellingShingle |
MELI-POP Study: MEditerranean LIfestyle in Pediatric Obesity Prevention. Study protocol for a randomized controlled trial Miguel Etayo, Pilar de Obesity prevention Mediterranean Diet Physical Activity Pediatric obesity 3201 Ciencias clínicas |
| title_short |
MELI-POP Study: MEditerranean LIfestyle in Pediatric Obesity Prevention. Study protocol for a randomized controlled trial |
| title_full |
MELI-POP Study: MEditerranean LIfestyle in Pediatric Obesity Prevention. Study protocol for a randomized controlled trial |
| title_fullStr |
MELI-POP Study: MEditerranean LIfestyle in Pediatric Obesity Prevention. Study protocol for a randomized controlled trial |
| title_full_unstemmed |
MELI-POP Study: MEditerranean LIfestyle in Pediatric Obesity Prevention. Study protocol for a randomized controlled trial |
| title_sort |
MELI-POP Study: MEditerranean LIfestyle in Pediatric Obesity Prevention. Study protocol for a randomized controlled trial |
| dc.creator.none.fl_str_mv |
Miguel Etayo, Pilar de Flores Rojas, Katherine Vázquez Cobela, Rocío Jurado Castro, José Manuel Larruy García, Alicia Picáns Leis, Rosaura Castro-Collado, Cristina Pastor Villaescusa, Belén Llorente Cantarero, Francisco Jesús Aguilera, Concepción M. Gil Campos, Mercedes Leis Trabazo, María Rosaura Moreno, Luis A. |
| author |
Miguel Etayo, Pilar de |
| author_facet |
Miguel Etayo, Pilar de Flores Rojas, Katherine Vázquez Cobela, Rocío Jurado Castro, José Manuel Larruy García, Alicia Picáns Leis, Rosaura Castro-Collado, Cristina Pastor Villaescusa, Belén Llorente Cantarero, Francisco Jesús Aguilera, Concepción M. Gil Campos, Mercedes Leis Trabazo, María Rosaura Moreno, Luis A. |
| author_role |
author |
| author2 |
Flores Rojas, Katherine Vázquez Cobela, Rocío Jurado Castro, José Manuel Larruy García, Alicia Picáns Leis, Rosaura Castro-Collado, Cristina Pastor Villaescusa, Belén Llorente Cantarero, Francisco Jesús Aguilera, Concepción M. Gil Campos, Mercedes Leis Trabazo, María Rosaura Moreno, Luis A. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría |
| dc.subject.none.fl_str_mv |
Obesity prevention Mediterranean Diet Physical Activity Pediatric obesity 3201 Ciencias clínicas |
| topic |
Obesity prevention Mediterranean Diet Physical Activity Pediatric obesity 3201 Ciencias clínicas |
| description |
Background Childhood obesity is a significant public health challenge, with Mediterranean countries showing high prevalence rates. While genetic factors play a role, diet and physical activity (PA) are critical modifiable influences. Emphasizing healthy dietary patterns, like the Mediterranean diet, and promoting regular PA can help mitigate obesity risk. Methods MELI-POP is a randomized controlled multi-center clinical trial in a cohort of children aged 3 to 6 years at baseline and being at obesity risk. The main objective consists on assessing the efficacy of an intervention during early childhood, considering a healthy lifestyle based on the promotion of a Mediterranean dietary pattern and regular PA, compared with a control group, on decreasing obesity incidence 5 and 10 years after the beginning of the intervention. It is expected to include 310 children, aged 3 to 6 years, having at baseline a normal weight or overweight according to the International Obesity Task Force (IOTF) criteria, and at least one parent having a body mass index > 25 kg/m2. The clinical trial has two arms and is performed in Spanish Primary Health Care centers. The control group receive usual care by healthcare professionals. The intervention group receive education on Mediterranean diet and PA, combined with the provision of extra-virgin olive oil and fish, in order to be consumed at least 2 times per week. Free PA sessions with a physical education teacher are also offered for the children (3 sessions of 60 min of moderate-vigorous PA per week). The participants’ adherence to the intervention is periodically monitored. The study primarily focuses on adiposity as the main outcome, with secondary outcomes encompassing dietary intake and eating habits, physical activity and lifestyle behaviors (including extracurricular sports, screen time, and sleep duration), physical fitness, biochemical parameters (such as inflammation and cardiometabolic biomarkers, fatty acids, and oxidation), as well as microbiota, genetic, omic and metabolomic analyses. Discussion Beneficial results are expected by preventing obesity during childhood, and associated comorbidities. Trial registration ClinicalTrials.gov, ID: NCT04597281. |
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2025 |
| dc.date.none.fl_str_mv |
2025 2025-12-29 2025 2025-12-29 |
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journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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article |
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https://hdl.handle.net/10347/45267 |
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https://hdl.handle.net/10347/45267 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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BMC |
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BMC |
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reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela instname:Universidad de Santiago de Compostela (USC) |
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Universidad de Santiago de Compostela (USC) |
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MELI-POP Study: MEditerranean LIfestyle in Pediatric Obesity Prevention. Study protocol for a randomized controlled trialMiguel Etayo, Pilar deFlores Rojas, KatherineVázquez Cobela, RocíoJurado Castro, José ManuelLarruy García, AliciaPicáns Leis, RosauraCastro-Collado, CristinaPastor Villaescusa, BelénLlorente Cantarero, Francisco JesúsAguilera, Concepción M.Gil Campos, MercedesLeis Trabazo, María RosauraMoreno, Luis A.Obesity preventionMediterranean DietPhysical ActivityPediatric obesity3201 Ciencias clínicasBackground Childhood obesity is a significant public health challenge, with Mediterranean countries showing high prevalence rates. While genetic factors play a role, diet and physical activity (PA) are critical modifiable influences. Emphasizing healthy dietary patterns, like the Mediterranean diet, and promoting regular PA can help mitigate obesity risk. Methods MELI-POP is a randomized controlled multi-center clinical trial in a cohort of children aged 3 to 6 years at baseline and being at obesity risk. The main objective consists on assessing the efficacy of an intervention during early childhood, considering a healthy lifestyle based on the promotion of a Mediterranean dietary pattern and regular PA, compared with a control group, on decreasing obesity incidence 5 and 10 years after the beginning of the intervention. It is expected to include 310 children, aged 3 to 6 years, having at baseline a normal weight or overweight according to the International Obesity Task Force (IOTF) criteria, and at least one parent having a body mass index > 25 kg/m2. The clinical trial has two arms and is performed in Spanish Primary Health Care centers. The control group receive usual care by healthcare professionals. The intervention group receive education on Mediterranean diet and PA, combined with the provision of extra-virgin olive oil and fish, in order to be consumed at least 2 times per week. Free PA sessions with a physical education teacher are also offered for the children (3 sessions of 60 min of moderate-vigorous PA per week). The participants’ adherence to the intervention is periodically monitored. The study primarily focuses on adiposity as the main outcome, with secondary outcomes encompassing dietary intake and eating habits, physical activity and lifestyle behaviors (including extracurricular sports, screen time, and sleep duration), physical fitness, biochemical parameters (such as inflammation and cardiometabolic biomarkers, fatty acids, and oxidation), as well as microbiota, genetic, omic and metabolomic analyses. Discussion Beneficial results are expected by preventing obesity during childhood, and associated comorbidities. Trial registration ClinicalTrials.gov, ID: NCT04597281.BMCUniversidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría20252025-12-2920252025-12-29journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/45267reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit h t t p : / / c r e a t i v e c o m m o n s . o r g / l i c e n s e s / b y - n c - n d / 4 . 0 /.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/452672026-06-15T12:47:27Z |
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