Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study

Background & aims Circadian rhythms seem to impact both dietary intake and metabolism, depending on the individual's chronotype. We aimed to explore whether the nutritional composition of meals throughout the day is influenced by genetics linked to the circadian clock and chronotype within...

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Autores: Molina-Montes, Esther, Rodríguez-Barranco, Miguel, Alcalá-Santiago, Ángela, Gálvez Navas, José María, Huerta, José María, Amiano, Pilar, Lasheras-Mayo, Maria Cristina, Moreno Iribas, Conchi, Jimenez-Zabala, Ana, Chirlaque, Maria-Dolores, Gasque, Alba, Lujan-Barroso, Leila, Agudo, Antonio, Jakszyn, Paula, Quirós, José Ramón, Sánchez, María-José
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Universitat Ramon Llull (URL)
Repositorio:DAU Arxiu Digital de la Universitat Ramon Llull
OAI Identifier:oai:dau.url.edu:20.500.14342/5799
Acesso em linha:http://hdl.handle.net/20.500.14342/5799
https://doi.org/10.1016/j.clnu.2025.04.023
Access Level:acceso abierto
Palavra-chave:Cronobiologia
Ritmes circadians
Antropometria
Nutrició
Hàbits alimentaris
Anàlisi d'associació genètica
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spelling Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet studyMolina-Montes, EstherRodríguez-Barranco, MiguelAlcalá-Santiago, ÁngelaGálvez Navas, José MaríaHuerta, José MaríaAmiano, PilarLasheras-Mayo, Maria CristinaMoreno Iribas, ConchiJimenez-Zabala, AnaChirlaque, Maria-DoloresGasque, AlbaLujan-Barroso, LeilaAgudo, AntonioJakszyn, PaulaQuirós, José RamónSánchez, María-JoséCronobiologiaRitmes circadiansAntropometriaNutricióHàbits alimentarisAnàlisi d'associació genèticaBackground & aims Circadian rhythms seem to impact both dietary intake and metabolism, depending on the individual's chronotype. We aimed to explore whether the nutritional composition of meals throughout the day is influenced by genetics linked to the circadian clock and chronotype within the “European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet” study. Methods The study population comprised 3,183 subjects with information on diet and twelve genetic variants of six genes (PER1, PER2, PER3, CRY1, NR1D1, CLOCK). The associations between the variants with chrononutrition variables (macronutrients and serving sizes of each meal) were evaluated using linear regression, considering an additive genetic model, and adjusting for sex, age and center, among others. The β coefficients, 95 % confidence intervals (CI), and p-values corrected for multiple comparisons were estimated. A genetic risk score (GRS) that was associated to the evening/late chronotype as well as overweight/obesity in a previous study, the chronotype-GRS, was tested for its association with chrononutrition variables. Results The nutritional profile of the diet differed according to the individual's chronotype, with evening/late chronotypes exhibiting an unbalanced intake during breakfast and dinner compared to the intermediate and early chronotypes (e.g., percentage of fats consumed at breakfast relative to the total fat intake: 13 % and 9 %, respectively). However, significant differences were not encountered by the chronotype-GRS. In multivariate analyses, individual associations between the genetic variants and the nutrients revealed some nominal associations (e.g., rs1801260 and rs2070062 with carbohydrates at breakfast: β = −0.06 to 0.08). Higher scorings of the chronotype-GRS were inversely associated with the intake of proteins and carbohydrates (β = −0.46 and −0.41; nominal p-value<0.006; corrected = 0.25) during breakfast. Also, there was an inverse association between the chronotype-GRS and the breakfast's portion size (β = −0.3; nominal p-value = 0.03; corrected = 0.1). Conclusions Genetic susceptibility to an evening-like chronotype prone to overweight/obesity seems to be associated with a smaller serving size during breakfast, with lower protein and carbohydrate content.info:eu-repo/semantics/publishedVersionElsevierUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna2026202620242025info:eu-repo/semantics/article13 p.application/pdfhttp://hdl.handle.net/20.500.14342/5799https://doi.org/10.1016/j.clnu.2025.04.023reponame:DAU Arxiu Digital de la Universitat Ramon Llullinstname:Universitat Ramon Llull (URL)InglésClinical Nutrition, 2025, 49: 165-177info:eu-repo/grantAgreement/MINSA/ISCIII/PI15info:eu-repo/grantAgreement/MINSA/ISCIII/PI15info:eu-repo/grantAgreement/MINSA/ISCIII/PI15info:eu-repo/grantAgreement/MINSA/ISCIII/PI15info:eu-repo/grantAgreement/MINSA/ISCIII/PI15info:eu-repo/grantAgreement/Fundació la Marató de TV3/grant no. 201604-10/© L'autor/aAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dau.url.edu:20.500.14342/57992026-06-21T06:40:37Z
dc.title.none.fl_str_mv Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
title Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
spellingShingle Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
Molina-Montes, Esther
Cronobiologia
Ritmes circadians
Antropometria
Nutrició
Hàbits alimentaris
Anàlisi d'associació genètica
title_short Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
title_full Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
title_fullStr Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
title_full_unstemmed Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
title_sort Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study
dc.creator.none.fl_str_mv Molina-Montes, Esther
Rodríguez-Barranco, Miguel
Alcalá-Santiago, Ángela
Gálvez Navas, José María
Huerta, José María
Amiano, Pilar
Lasheras-Mayo, Maria Cristina
Moreno Iribas, Conchi
Jimenez-Zabala, Ana
Chirlaque, Maria-Dolores
Gasque, Alba
Lujan-Barroso, Leila
Agudo, Antonio
Jakszyn, Paula
Quirós, José Ramón
Sánchez, María-José
author Molina-Montes, Esther
author_facet Molina-Montes, Esther
Rodríguez-Barranco, Miguel
Alcalá-Santiago, Ángela
Gálvez Navas, José María
Huerta, José María
Amiano, Pilar
Lasheras-Mayo, Maria Cristina
Moreno Iribas, Conchi
Jimenez-Zabala, Ana
Chirlaque, Maria-Dolores
Gasque, Alba
Lujan-Barroso, Leila
Agudo, Antonio
Jakszyn, Paula
Quirós, José Ramón
Sánchez, María-José
author_role author
author2 Rodríguez-Barranco, Miguel
Alcalá-Santiago, Ángela
Gálvez Navas, José María
Huerta, José María
Amiano, Pilar
Lasheras-Mayo, Maria Cristina
Moreno Iribas, Conchi
Jimenez-Zabala, Ana
Chirlaque, Maria-Dolores
Gasque, Alba
Lujan-Barroso, Leila
Agudo, Antonio
Jakszyn, Paula
Quirós, José Ramón
Sánchez, María-José
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.subject.none.fl_str_mv Cronobiologia
Ritmes circadians
Antropometria
Nutrició
Hàbits alimentaris
Anàlisi d'associació genètica
topic Cronobiologia
Ritmes circadians
Antropometria
Nutrició
Hàbits alimentaris
Anàlisi d'associació genètica
description Background & aims Circadian rhythms seem to impact both dietary intake and metabolism, depending on the individual's chronotype. We aimed to explore whether the nutritional composition of meals throughout the day is influenced by genetics linked to the circadian clock and chronotype within the “European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet” study. Methods The study population comprised 3,183 subjects with information on diet and twelve genetic variants of six genes (PER1, PER2, PER3, CRY1, NR1D1, CLOCK). The associations between the variants with chrononutrition variables (macronutrients and serving sizes of each meal) were evaluated using linear regression, considering an additive genetic model, and adjusting for sex, age and center, among others. The β coefficients, 95 % confidence intervals (CI), and p-values corrected for multiple comparisons were estimated. A genetic risk score (GRS) that was associated to the evening/late chronotype as well as overweight/obesity in a previous study, the chronotype-GRS, was tested for its association with chrononutrition variables. Results The nutritional profile of the diet differed according to the individual's chronotype, with evening/late chronotypes exhibiting an unbalanced intake during breakfast and dinner compared to the intermediate and early chronotypes (e.g., percentage of fats consumed at breakfast relative to the total fat intake: 13 % and 9 %, respectively). However, significant differences were not encountered by the chronotype-GRS. In multivariate analyses, individual associations between the genetic variants and the nutrients revealed some nominal associations (e.g., rs1801260 and rs2070062 with carbohydrates at breakfast: β = −0.06 to 0.08). Higher scorings of the chronotype-GRS were inversely associated with the intake of proteins and carbohydrates (β = −0.46 and −0.41; nominal p-value<0.006; corrected = 0.25) during breakfast. Also, there was an inverse association between the chronotype-GRS and the breakfast's portion size (β = −0.3; nominal p-value = 0.03; corrected = 0.1). Conclusions Genetic susceptibility to an evening-like chronotype prone to overweight/obesity seems to be associated with a smaller serving size during breakfast, with lower protein and carbohydrate content.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/5799
https://doi.org/10.1016/j.clnu.2025.04.023
url http://hdl.handle.net/20.500.14342/5799
https://doi.org/10.1016/j.clnu.2025.04.023
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Clinical Nutrition, 2025, 49: 165-177
info:eu-repo/grantAgreement/MINSA/ISCIII/PI15
info:eu-repo/grantAgreement/MINSA/ISCIII/PI15
info:eu-repo/grantAgreement/MINSA/ISCIII/PI15
info:eu-repo/grantAgreement/MINSA/ISCIII/PI15
info:eu-repo/grantAgreement/MINSA/ISCIII/PI15
info:eu-repo/grantAgreement/Fundació la Marató de TV3/grant no. 201604-10/
dc.rights.none.fl_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DAU Arxiu Digital de la Universitat Ramon Llull
instname:Universitat Ramon Llull (URL)
instname_str Universitat Ramon Llull (URL)
reponame_str DAU Arxiu Digital de la Universitat Ramon Llull
collection DAU Arxiu Digital de la Universitat Ramon Llull
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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