Biomass-derived isosorbide-based thermoresponsive hydrogel for drug delivery

Herein, we describe the design and synthesis of a new variety of bio-based hydrogel films using a Cu(I)-catalyzed photo-click reaction. These films exhibited thermal-triggered swelling–deswelling and were constructed by crosslinking a triazide derivative of glycerol ethoxylate and dialkyne structure...

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Detalhes bibliográficos
Autores: Díaz Díaz, David, Bonardd, Sebastián, Maiti, Binoy, Grijalvo, Santiago, Rodríguez, Jacqueline, Enshaei, Hamidreza, Kortaberria, Galder, Alemán, Carlos
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Universidad de La Laguna (ULL)
Repositorio:RIULL. Repositorio Institucional de la Universidad de La Laguna
OAI Identifier:oai:riull.ull.es:915/42209
Acesso em linha:http://riull.ull.es/xmlui/handle/915/42209
Access Level:acceso abierto
Palavra-chave:bio-based hydrogel
isosorbide-based thermoresponsive hydrogel
drug delivery
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spelling Biomass-derived isosorbide-based thermoresponsive hydrogel for drug deliveryDíaz Díaz, DavidBonardd, SebastiánMaiti, BinoyGrijalvo, SantiagoRodríguez, JacquelineEnshaei, HamidrezaKortaberria, GalderAlemán, Carlosbio-based hydrogelisosorbide-based thermoresponsive hydrogeldrug deliveryHerein, we describe the design and synthesis of a new variety of bio-based hydrogel films using a Cu(I)-catalyzed photo-click reaction. These films exhibited thermal-triggered swelling–deswelling and were constructed by crosslinking a triazide derivative of glycerol ethoxylate and dialkyne structures derived from isosorbide, a well-known plant-based platform molecule. The success of the click reaction was corroborated through infrared spectroscopy (FTIR) and the smooth surface of the obtained films was confirmed by scanning electron microscopy (SEM). The thermal characterization was carried out in terms of thermogravimetry (TGA) and differential scanning calorimetry (DSC), from which the decomposition onset and glass transition temperatures were determined, respectively. Additionally, mechanical properties of the samples were estimated by stress–strain experiments. Then, their swelling and deswelling properties were systematically examined in PBS buffer, revealing a thermoresponsive behavior that was successfully tested in the release of the anticancer drug doxorubicin. We also confirmed the non-cytotoxicity of these materials, which is a fundamental aspect for their potential use as drug carriers or tissue engineering matrices.Royal Society of Chemistry202520252022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://riull.ull.es/xmlui/handle/915/42209reponame:RIULL. Repositorio Institucional de la Universidad de La Lagunainstname:Universidad de La Laguna (ULL)InglésSoft Matter;18, 2022Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:riull.ull.es:915/422092026-06-22T13:13:57Z
dc.title.none.fl_str_mv Biomass-derived isosorbide-based thermoresponsive hydrogel for drug delivery
title Biomass-derived isosorbide-based thermoresponsive hydrogel for drug delivery
spellingShingle Biomass-derived isosorbide-based thermoresponsive hydrogel for drug delivery
Díaz Díaz, David
bio-based hydrogel
isosorbide-based thermoresponsive hydrogel
drug delivery
title_short Biomass-derived isosorbide-based thermoresponsive hydrogel for drug delivery
title_full Biomass-derived isosorbide-based thermoresponsive hydrogel for drug delivery
title_fullStr Biomass-derived isosorbide-based thermoresponsive hydrogel for drug delivery
title_full_unstemmed Biomass-derived isosorbide-based thermoresponsive hydrogel for drug delivery
title_sort Biomass-derived isosorbide-based thermoresponsive hydrogel for drug delivery
dc.creator.none.fl_str_mv Díaz Díaz, David
Bonardd, Sebastián
Maiti, Binoy
Grijalvo, Santiago
Rodríguez, Jacqueline
Enshaei, Hamidreza
Kortaberria, Galder
Alemán, Carlos
author Díaz Díaz, David
author_facet Díaz Díaz, David
Bonardd, Sebastián
Maiti, Binoy
Grijalvo, Santiago
Rodríguez, Jacqueline
Enshaei, Hamidreza
Kortaberria, Galder
Alemán, Carlos
author_role author
author2 Bonardd, Sebastián
Maiti, Binoy
Grijalvo, Santiago
Rodríguez, Jacqueline
Enshaei, Hamidreza
Kortaberria, Galder
Alemán, Carlos
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv bio-based hydrogel
isosorbide-based thermoresponsive hydrogel
drug delivery
topic bio-based hydrogel
isosorbide-based thermoresponsive hydrogel
drug delivery
description Herein, we describe the design and synthesis of a new variety of bio-based hydrogel films using a Cu(I)-catalyzed photo-click reaction. These films exhibited thermal-triggered swelling–deswelling and were constructed by crosslinking a triazide derivative of glycerol ethoxylate and dialkyne structures derived from isosorbide, a well-known plant-based platform molecule. The success of the click reaction was corroborated through infrared spectroscopy (FTIR) and the smooth surface of the obtained films was confirmed by scanning electron microscopy (SEM). The thermal characterization was carried out in terms of thermogravimetry (TGA) and differential scanning calorimetry (DSC), from which the decomposition onset and glass transition temperatures were determined, respectively. Additionally, mechanical properties of the samples were estimated by stress–strain experiments. Then, their swelling and deswelling properties were systematically examined in PBS buffer, revealing a thermoresponsive behavior that was successfully tested in the release of the anticancer drug doxorubicin. We also confirmed the non-cytotoxicity of these materials, which is a fundamental aspect for their potential use as drug carriers or tissue engineering matrices.
publishDate 2022
dc.date.none.fl_str_mv 2022
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://riull.ull.es/xmlui/handle/915/42209
url http://riull.ull.es/xmlui/handle/915/42209
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Soft Matter;18, 2022
dc.rights.none.fl_str_mv Atribución-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:RIULL. Repositorio Institucional de la Universidad de La Laguna
instname:Universidad de La Laguna (ULL)
instname_str Universidad de La Laguna (ULL)
reponame_str RIULL. Repositorio Institucional de la Universidad de La Laguna
collection RIULL. Repositorio Institucional de la Universidad de La Laguna
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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